Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1371/journal.pone.0244981 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46166 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de doenças febris agudas. Rio de Janeiro, RJ, Brasil. |
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Calvet, Guilherme AmaralKara, Edna OliveiraLandoulsi, SihemHabib, NdemaBôtto-Menezes, Camila Helena AguiarFranca, Rafael Freitas de OliveiraNeto, Armando MenezesCastilho, Marcia da CostaFernandes, Tatiana JorgePereira, Gerson FernandoGiozza, Silvana PereiraBermúdez, Ximena Pamela DíazModjarrad, KayvonLima, NoemiaBrasil, PatríciaLacerda, Marcus Vinicius Guimarães deFilippis, Ana Maria Bispo deBroutet, Nathalie Jeanne NicoleZIKABRA Study Team2021-02-25T00:00:51Z2021-02-25T00:00:51Z2021CALVET, Guilherme Amaral et al. Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study). PloS one, v. 16, n. 1, p. 1-17, 20211932-6203https://www.arca.fiocruz.br/handle/icict/4616610.1371/journal.pone.0244981engPublic Library of ScienceZika vírusSangueUrinaSêmenFluidos corporaisRetoSalivaBrasilZika virusBloodUrineSemenBody fluidsRectumSalivaBrazilCohort profile: Study on Zika virus infection in Brazil (ZIKABRA study)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de doenças febris agudas. Rio de Janeiro, RJ, Brasil.World Health Organization. Department of Sexual and Reproductive Health and Research. Geneva, Switzerland.World Health Organization. Department of Sexual and Reproductive Health and Research. Geneva, Switzerland.World Health Organization. Department of Sexual and Reproductive Health and Research. Geneva, Switzerland.Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD). Department of Malaria. Manaus, AM, Brazil / Amazonas State University (UEA). School of Health Sciences. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD). Department of Malaria. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de doenças febris agudas. Rio de Janeiro, RJ, Brasil.Ministry of Health. Health Surveillance Secretariat. Department of Chronic Condition Diseases and Sexually Transmitted Infections. Brasilia, DF, Brazil.Ministry of Health. Health Surveillance Secretariat. Department of Chronic Condition Diseases and Sexually Transmitted Infections. Brasilia, DF, Brazil.University of Brasilia. Department of Public Health. Brasília, DF, Brazil.Walter Reed Army Institute of Research. Emerging Infectious Diseases Branch. Silver Spring, MD, United States of America.Walter Reed Army Institute of Research. Emerging Infectious Diseases Branch. Silver Spring, MD, United States of America.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de doenças febris agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil / Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD). Department of Malaria. Manaus, AM, Brazil / Amazonas State University (UEA). School of Health Sciences. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.World Health Organization. Department of Sexual and Reproductive Health and Research. Geneva, Switzerland.Zika virus (ZIKV) has been detected in blood, urine, semen, cerebral spinal fluid, saliva, amniotic fluid, and breast milk. In most ZIKV infected individuals, the virus is detected in the blood to one week after the onset of symptoms and has been found to persist longer in urine and semen. To better understand virus dynamics, a prospective cohort study was conducted in Brazil to assess the presence and duration of ZIKV and related markers (viral RNA, antibodies, T cell response, and innate immunity) in blood, semen, saliva, urine, vaginal secretions/menstrual blood, rectal swab and sweat. The objective of the current manuscript is to describe the cohort, including an overview of the collected data and a description of the baseline characteristics of the participants. Men and women ≥ 18 years with acute illness and their symptomatic and asymptomatic household contacts with positive reverse transcriptase-polymerase chain reaction test for ZIKV in blood and/or urine were included. All participants were followed up for 12 months. From July 2017 to June 2019, a total of 786 participants (284 men, 502 women) were screened. Of these, 260 (33.1%) were enrolled in the study; index cases: 64 men (24.6%), 162 (62.3%) women; household contacts: 12 men (4.6%), 22 (8.5%) women. There was a statistically significant difference in age and sex between enrolled and not enrolled participants (p<0.005). Baseline sociodemographic and medical data were collected at enrollment from all participants. The median and interquartile range (IQR) age was 35 (IQR; 25.3, 43) for men and 36.5 years (IQR; 28, 47) for women. Following rash, which was one of the inclusion criteria for index cases, the most reported symptoms in the enrollment visit since the onset of the disease were fever, itching, arthralgia with or without edema, non-purulent conjunctivitis, headache, and myalgia. Ten hospitalizations were reported by eight patients (two patients were hospitalized twice) during follow up, after a median of 108 days following symptom onset (range 7 to 266 days) and with a median of 1.5 days (range 1 to 20 days) of hospital stay. A total of 4,137 visits were performed, 223 (85.8%) participants have attended all visits and 37 (14.2%) patients were discontinued.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/46166/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALCohort profile_Guilherme_Calvet_etal_INI_2021.pdfCohort profile_Guilherme_Calvet_etal_INI_2021.pdfapplication/pdf986852https://www.arca.fiocruz.br/bitstream/icict/46166/2/Cohort%20profile_Guilherme_Calvet_etal_INI_2021.pdf1b016c73a47c6b98cdc742125bbe5baeMD52TEXTCohort profile_Guilherme_Calvet_etal_INI_2021.pdf.txtCohort profile_Guilherme_Calvet_etal_INI_2021.pdf.txtExtracted texttext/plain51743https://www.arca.fiocruz.br/bitstream/icict/46166/3/Cohort%20profile_Guilherme_Calvet_etal_INI_2021.pdf.txt4d1079a8b8b583917018c1655d4bc2a4MD53icict/461662021-02-25 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Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study) |
| title |
Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study) |
| spellingShingle |
Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study) Calvet, Guilherme Amaral Zika vírus Sangue Urina Sêmen Fluidos corporais Reto Saliva Brasil Zika virus Blood Urine Semen Body fluids Rectum Saliva Brazil |
| title_short |
Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study) |
| title_full |
Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study) |
| title_fullStr |
Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study) |
| title_full_unstemmed |
Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study) |
| title_sort |
Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study) |
| author |
Calvet, Guilherme Amaral |
| author_facet |
Calvet, Guilherme Amaral Kara, Edna Oliveira Landoulsi, Sihem Habib, Ndema Bôtto-Menezes, Camila Helena Aguiar Franca, Rafael Freitas de Oliveira Neto, Armando Menezes Castilho, Marcia da Costa Fernandes, Tatiana Jorge Pereira, Gerson Fernando Giozza, Silvana Pereira Bermúdez, Ximena Pamela Díaz Modjarrad, Kayvon Lima, Noemia Brasil, Patrícia Lacerda, Marcus Vinicius Guimarães de Filippis, Ana Maria Bispo de Broutet, Nathalie Jeanne Nicole ZIKABRA Study Team |
| author_role |
author |
| author2 |
Kara, Edna Oliveira Landoulsi, Sihem Habib, Ndema Bôtto-Menezes, Camila Helena Aguiar Franca, Rafael Freitas de Oliveira Neto, Armando Menezes Castilho, Marcia da Costa Fernandes, Tatiana Jorge Pereira, Gerson Fernando Giozza, Silvana Pereira Bermúdez, Ximena Pamela Díaz Modjarrad, Kayvon Lima, Noemia Brasil, Patrícia Lacerda, Marcus Vinicius Guimarães de Filippis, Ana Maria Bispo de Broutet, Nathalie Jeanne Nicole ZIKABRA Study Team |
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author author author author author author author author author author author author author author author author author author |
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Calvet, Guilherme Amaral Kara, Edna Oliveira Landoulsi, Sihem Habib, Ndema Bôtto-Menezes, Camila Helena Aguiar Franca, Rafael Freitas de Oliveira Neto, Armando Menezes Castilho, Marcia da Costa Fernandes, Tatiana Jorge Pereira, Gerson Fernando Giozza, Silvana Pereira Bermúdez, Ximena Pamela Díaz Modjarrad, Kayvon Lima, Noemia Brasil, Patrícia Lacerda, Marcus Vinicius Guimarães de Filippis, Ana Maria Bispo de Broutet, Nathalie Jeanne Nicole ZIKABRA Study Team |
| dc.subject.other.pt_BR.fl_str_mv |
Zika vírus Sangue Urina Sêmen Fluidos corporais Reto Saliva Brasil |
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Zika vírus Sangue Urina Sêmen Fluidos corporais Reto Saliva Brasil Zika virus Blood Urine Semen Body fluids Rectum Saliva Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Blood Urine Semen Body fluids Rectum Saliva Brazil |
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Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de doenças febris agudas. Rio de Janeiro, RJ, Brasil. |
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2021 |
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2021 |
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info:eu-repo/semantics/article |
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CALVET, Guilherme Amaral et al. Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study). PloS one, v. 16, n. 1, p. 1-17, 2021 |
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https://www.arca.fiocruz.br/handle/icict/46166 |
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1932-6203 |
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10.1371/journal.pone.0244981 |
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CALVET, Guilherme Amaral et al. Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study). PloS one, v. 16, n. 1, p. 1-17, 2021 1932-6203 10.1371/journal.pone.0244981 |
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