Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20889 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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Santos, Patrícia d'Emery AlvesLorena, Virgínia Maria Barros deFernandes, Érica de SouzaSales, Iana Rafaela FernandesNascimento, Wheverton Ricardo Correia doGomes, Yara de MirandaAlbuquerque, Mônica Camelo Pessoa de AzevedoCosta, Vlaudia Maria AssisSouza, Valdênia Maria Oliveira de2017-09-01T13:58:39Z2017-09-01T13:58:39Z2016SANTOS, P. D’EMERY A. et al. Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection. Memorias Do Instituto Oswaldo Cruz, v. 111, n. 2, p. 83–92, fev. 2016.1678-8060https://www.arca.fiocruz.br/handle/icict/2088910.1590/0074-02760150293porHepatopatias ParasitáriasGranuloma de Corpo EstranhoAnticorpos Anti-HelmínticosSchistosoma mansoniAnimais LactentesSchistosomiasis mansoniAnimais Recém-NascidosGranuloma, Foreign-BodyLiver Diseases, ParasiticSchistosoma mansoniAnimals, SucklingAdjuvants, ImmunologicAnimalsAnimals, NewbornAntibodies, HelminthCD4-Positive T-LymphocytesCercariaEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryForkhead Transcription FactorsImmunity, HeterologousImmunity, HumoralImmunoglobulin GInterferon-gammaInterleukin-4Interleukin-10Liver CirrhosisMaleMiceMothersOvalbuminPregnancySchistosomiasis mansoniSpleenAnticorpos Anti-HelmínticosHepatopatias ParasitáriasGranuloma de Corpo EstranhoSchistosoma mansoniAnimais LactentesEsquistossomose mansoniFemininoAnimaisMasculinoMãesGravidezOvalbuminaBaçoCamundongosCirrose HepáticaInterleucina-4Interleucina-10Interferon gamaImunoglobulina GImunidade HumoralImunidade HeterólogaFatores de Transcrição ForkheadCitometria de FluxoEnsaio de Imunoadsorção EnzimáticaCercariaLinfócitos T CD4-PositivosAnimais Recém-NascidosAdjuvantes ImunológicosGestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, BrasilSchistosoma mansoni antigens in the early life alter homologous and heterologous immunity during postnatal infections. We evaluate the immunity to parasite antigens and ovalbumin (OA) in adult mice born/suckled by schistosomotic mothers. Newborns were divided into: born (BIM), suckled (SIM) or born/suckled (BSIM) in schistosomotic mothers, and animals from noninfected mothers (control). When adults, the mice were infected and compared the hepatic granuloma size and cellularity. Some animals were OA + adjuvant immunised. We evaluated hypersensitivity reactions (HR), antibodies levels (IgG1/IgG2a) anti-soluble egg antigen and anti-soluble worm antigen preparation, and anti-OA, cytokine production, and CD4+FoxP3+T-cells by splenocytes. Compared to control group, BIM mice showed a greater quantity of granulomas and collagen deposition, whereas SIM and BSIM presented smaller granulomas. BSIM group exhibited the lowest levels of anti-parasite antibodies. For anti-OA immunity, immediate HR was suppressed in all groups, with greater intensity in SIM mice accompanied of the remarkable level of basal CD4+FoxP3+T-cells. BIM and SIM groups produced less interleukin (IL)-4 and interferon (IFN)-g. In BSIM, there was higher production of IL-10 and IFN-g, but lower levels of IL-4 and CD4+FoxP3+T-cells. Thus, pregnancy in schistosomotic mothers intensified hepatic fibrosis, whereas breastfeeding diminished granulomas in descendants. Separately, pregnancy and breastfeeding could suppress heterologous immunity; however, when combined, the responses could be partially restored in infected descendants.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20889/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL26872339 2016 san-ges.oa.pdf26872339 2016 san-ges.oa.pdfapplication/pdf1698870https://www.arca.fiocruz.br/bitstream/icict/20889/2/26872339%202016%20san-ges.oa.pdfe40dfc9f32e48eb9116565e13d2317d7MD52TEXT26872339 2016 san-ges.oa.pdf.txt26872339 2016 san-ges.oa.pdf.txtExtracted texttext/plain47490https://www.arca.fiocruz.br/bitstream/icict/20889/3/26872339%202016%20san-ges.oa.pdf.txt073d676c3cd847559f06f0f2bcaa9c51MD53icict/208892018-08-15 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Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection |
| title |
Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection |
| spellingShingle |
Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection Santos, Patrícia d'Emery Alves Hepatopatias Parasitárias Granuloma de Corpo Estranho Anticorpos Anti-Helmínticos Schistosoma mansoni Animais Lactentes Schistosomiasis mansoni Animais Recém-Nascidos Granuloma, Foreign-Body Liver Diseases, Parasitic Schistosoma mansoni Animals, Suckling Adjuvants, Immunologic Animals Animals, Newborn Antibodies, Helminth CD4-Positive T-Lymphocytes Cercaria Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Forkhead Transcription Factors Immunity, Heterologous Immunity, Humoral Immunoglobulin G Interferon-gamma Interleukin-4 Interleukin-10 Liver Cirrhosis Male Mice Mothers Ovalbumin Pregnancy Schistosomiasis mansoni Spleen Anticorpos Anti-Helmínticos Hepatopatias Parasitárias Granuloma de Corpo Estranho Schistosoma mansoni Animais Lactentes Esquistossomose mansoni Feminino Animais Masculino Mães Gravidez Ovalbumina Baço Camundongos Cirrose Hepática Interleucina-4 Interleucina-10 Interferon gama Imunoglobulina G Imunidade Humoral Imunidade Heteróloga Fatores de Transcrição Forkhead Citometria de Fluxo Ensaio de Imunoadsorção Enzimática Cercaria Linfócitos T CD4-Positivos Animais Recém-Nascidos Adjuvantes Imunológicos |
| title_short |
Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection |
| title_full |
Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection |
| title_fullStr |
Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection |
| title_full_unstemmed |
Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection |
| title_sort |
Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection |
| author |
Santos, Patrícia d'Emery Alves |
| author_facet |
Santos, Patrícia d'Emery Alves Lorena, Virgínia Maria Barros de Fernandes, Érica de Souza Sales, Iana Rafaela Fernandes Nascimento, Wheverton Ricardo Correia do Gomes, Yara de Miranda Albuquerque, Mônica Camelo Pessoa de Azevedo Costa, Vlaudia Maria Assis Souza, Valdênia Maria Oliveira de |
| author_role |
author |
| author2 |
Lorena, Virgínia Maria Barros de Fernandes, Érica de Souza Sales, Iana Rafaela Fernandes Nascimento, Wheverton Ricardo Correia do Gomes, Yara de Miranda Albuquerque, Mônica Camelo Pessoa de Azevedo Costa, Vlaudia Maria Assis Souza, Valdênia Maria Oliveira de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Patrícia d'Emery Alves Lorena, Virgínia Maria Barros de Fernandes, Érica de Souza Sales, Iana Rafaela Fernandes Nascimento, Wheverton Ricardo Correia do Gomes, Yara de Miranda Albuquerque, Mônica Camelo Pessoa de Azevedo Costa, Vlaudia Maria Assis Souza, Valdênia Maria Oliveira de |
| dc.subject.other.pt_BR.fl_str_mv |
Hepatopatias Parasitárias Granuloma de Corpo Estranho Anticorpos Anti-Helmínticos Schistosoma mansoni Animais Lactentes Schistosomiasis mansoni Animais Recém-Nascidos |
| topic |
Hepatopatias Parasitárias Granuloma de Corpo Estranho Anticorpos Anti-Helmínticos Schistosoma mansoni Animais Lactentes Schistosomiasis mansoni Animais Recém-Nascidos Granuloma, Foreign-Body Liver Diseases, Parasitic Schistosoma mansoni Animals, Suckling Adjuvants, Immunologic Animals Animals, Newborn Antibodies, Helminth CD4-Positive T-Lymphocytes Cercaria Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Forkhead Transcription Factors Immunity, Heterologous Immunity, Humoral Immunoglobulin G Interferon-gamma Interleukin-4 Interleukin-10 Liver Cirrhosis Male Mice Mothers Ovalbumin Pregnancy Schistosomiasis mansoni Spleen Anticorpos Anti-Helmínticos Hepatopatias Parasitárias Granuloma de Corpo Estranho Schistosoma mansoni Animais Lactentes Esquistossomose mansoni Feminino Animais Masculino Mães Gravidez Ovalbumina Baço Camundongos Cirrose Hepática Interleucina-4 Interleucina-10 Interferon gama Imunoglobulina G Imunidade Humoral Imunidade Heteróloga Fatores de Transcrição Forkhead Citometria de Fluxo Ensaio de Imunoadsorção Enzimática Cercaria Linfócitos T CD4-Positivos Animais Recém-Nascidos Adjuvantes Imunológicos |
| dc.subject.en.pt_BR.fl_str_mv |
Granuloma, Foreign-Body Liver Diseases, Parasitic Schistosoma mansoni Animals, Suckling Adjuvants, Immunologic Animals Animals, Newborn Antibodies, Helminth CD4-Positive T-Lymphocytes Cercaria Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Forkhead Transcription Factors Immunity, Heterologous Immunity, Humoral Immunoglobulin G Interferon-gamma Interleukin-4 Interleukin-10 Liver Cirrhosis Male Mice Mothers Ovalbumin Pregnancy Schistosomiasis mansoni Spleen |
| dc.subject.decs.pt_BR.fl_str_mv |
Anticorpos Anti-Helmínticos Hepatopatias Parasitárias Granuloma de Corpo Estranho Schistosoma mansoni Animais Lactentes Esquistossomose mansoni Feminino Animais Masculino Mães Gravidez Ovalbumina Baço Camundongos Cirrose Hepática Interleucina-4 Interleucina-10 Interferon gama Imunoglobulina G Imunidade Humoral Imunidade Heteróloga Fatores de Transcrição Forkhead Citometria de Fluxo Ensaio de Imunoadsorção Enzimática Cercaria Linfócitos T CD4-Positivos Animais Recém-Nascidos Adjuvantes Imunológicos |
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Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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2016 |
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2016 |
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2017-09-01T13:58:39Z |
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2017-09-01T13:58:39Z |
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SANTOS, P. D’EMERY A. et al. Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection. Memorias Do Instituto Oswaldo Cruz, v. 111, n. 2, p. 83–92, fev. 2016. |
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https://www.arca.fiocruz.br/handle/icict/20889 |
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1678-8060 |
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10.1590/0074-02760150293 |
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SANTOS, P. D’EMERY A. et al. Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection. Memorias Do Instituto Oswaldo Cruz, v. 111, n. 2, p. 83–92, fev. 2016. 1678-8060 10.1590/0074-02760150293 |
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