Inhibition of Mayaro virus infection by bovine lactoferrin

Detalhes bibliográficos
Autor(a) principal: Carvalho, Carlos A. M.
Data de Publicação: 2014
Outros Autores: Sousa Junior, Ivanildo P., Silva, Jerson L., Oliveira, Andréa C., Gonçalves, Rafael B., Gomes, Andre M. O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32053
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
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spelling Carvalho, Carlos A. M.Sousa Junior, Ivanildo P.Silva, Jerson L.Oliveira, Andréa C.Gonçalves, Rafael B.Gomes, Andre M. O.2019-03-12T17:55:27Z2019-03-12T17:55:27Z2014CARVALHO, Carlos A. M. et al. Inhibition of Mayaro virus infection by bovine lactoferrin. Virology, New York, v. 452-453, p. 297-302, 2014.1096-0341https://www.arca.fiocruz.br/handle/icict/3205310.1016/j.virol.2014.01.022engInhibition of Mayaro virus infection by bovine lactoferrininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Instituto Biomédico. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Mayaro virus (MAYV) is an arbovirus linked to several sporadic outbreaks of a highly debilitating febrile illness in many regions of South America. MAYV is on the verge of urbanization from the Amazon region and no effective antiviral intervention is available against human infections. Our aim was to investigate whether bovine lactoferrin (bLf), an iron-binding glycoprotein, could hinder MAYV infection. We show that bLf promotes a strong inhibition of virus infection with no cytotoxic effects. Monitoring the effect of bLf on different stages of infection, we observed that virus entry into the cell is the heavily compromised event. Moreover, we found that binding of bLf to the cell is highly dependent on the sulfation of glycosaminoglycans, suggesting that bLf impairs virus entry by blocking these molecules. Our findings highlight the antiviral potential of bLf and reveal an effective strategy against one of the major emerging human pathogens in the neotropics.Antiviral activityBovine lactoferrinMayaro virusinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/32053/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALF94-1-s2.0-S004268221400035X-main.pdfapplication/pdf1939209https://www.arca.fiocruz.br/bitstream/icict/32053/2/F94-1-s2.0-S004268221400035X-main.pdfbfe711d42ac15f7170188f4c04fe2ef3MD52TEXTF94-1-s2.0-S004268221400035X-main.pdf.txtF94-1-s2.0-S004268221400035X-main.pdf.txtExtracted texttext/plain27112https://www.arca.fiocruz.br/bitstream/icict/32053/3/F94-1-s2.0-S004268221400035X-main.pdf.txte8391c5cfa16d4e2a68aff6987f0e0d5MD53icict/320532019-04-04 02:05:17.933oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-04-04T05:05:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Inhibition of Mayaro virus infection by bovine lactoferrin
title Inhibition of Mayaro virus infection by bovine lactoferrin
spellingShingle Inhibition of Mayaro virus infection by bovine lactoferrin
Carvalho, Carlos A. M.
Antiviral activity
Bovine lactoferrin
Mayaro virus
title_short Inhibition of Mayaro virus infection by bovine lactoferrin
title_full Inhibition of Mayaro virus infection by bovine lactoferrin
title_fullStr Inhibition of Mayaro virus infection by bovine lactoferrin
title_full_unstemmed Inhibition of Mayaro virus infection by bovine lactoferrin
title_sort Inhibition of Mayaro virus infection by bovine lactoferrin
author Carvalho, Carlos A. M.
author_facet Carvalho, Carlos A. M.
Sousa Junior, Ivanildo P.
Silva, Jerson L.
Oliveira, Andréa C.
Gonçalves, Rafael B.
Gomes, Andre M. O.
author_role author
author2 Sousa Junior, Ivanildo P.
Silva, Jerson L.
Oliveira, Andréa C.
Gonçalves, Rafael B.
Gomes, Andre M. O.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Carlos A. M.
Sousa Junior, Ivanildo P.
Silva, Jerson L.
Oliveira, Andréa C.
Gonçalves, Rafael B.
Gomes, Andre M. O.
dc.subject.en.pt_BR.fl_str_mv Antiviral activity
Bovine lactoferrin
Mayaro virus
topic Antiviral activity
Bovine lactoferrin
Mayaro virus
description Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2019-03-12T17:55:27Z
dc.date.available.fl_str_mv 2019-03-12T17:55:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Carlos A. M. et al. Inhibition of Mayaro virus infection by bovine lactoferrin. Virology, New York, v. 452-453, p. 297-302, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32053
dc.identifier.issn.pt_BR.fl_str_mv 1096-0341
dc.identifier.doi.none.fl_str_mv 10.1016/j.virol.2014.01.022
identifier_str_mv CARVALHO, Carlos A. M. et al. Inhibition of Mayaro virus infection by bovine lactoferrin. Virology, New York, v. 452-453, p. 297-302, 2014.
1096-0341
10.1016/j.virol.2014.01.022
url https://www.arca.fiocruz.br/handle/icict/32053
dc.language.iso.fl_str_mv eng
language eng
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