Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation

Bussotti, Giovanni; Gouzelou, Evi; Aoun, Karim; Bouratbine, Aïda; Cupolillo, Elisa; Späthb, Gerald F.; Kherachi, Ihcen; Harrat, Zoubir; Eddaikra, Naouel; Mottran, Jeremy C.; Antoniou, Maria; Christodoulou, Vasiliki; Bali, Aymen; Guerfali, Fatima Z.; Laouini, Dhafer; Mukhtar, Maowia; Dumetz, Franck; Dujardim, Jean-Claude; Smirlis, Despina; Lechar, Pierre; Pescher, Pascale; El Hamouchi, Adil; Lemrani, Meryem; Chicharro, Carmen; Llanes-Acevedo, Ivonne Pamela; Botana, Laura; Cruz, Israel; Boité, Mariana Côrtes; Moreno, Javier; Jeddi, Fakhn

Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation

Detalhes bibliográficos
Autor(a) principal:	Bussotti, Giovanni
Data de Publicação:	2018
Outros Autores:	Gouzelou, Evi, Aoun, Karim, Bouratbine, Aïda, Cupolillo, Elisa, Späthb, Gerald F., Kherachi, Ihcen, Harrat, Zoubir, Eddaikra, Naouel, Mottran, Jeremy C., Antoniou, Maria, Christodoulou, Vasiliki, Bali, Aymen, Guerfali, Fatima Z., Laouini, Dhafer, Mukhtar, Maowia, Dumetz, Franck, Dujardim, Jean-Claude, Smirlis, Despina, Lechar, Pierre, Pescher, Pascale, El Hamouchi, Adil, Lemrani, Meryem, Chicharro, Carmen, Llanes-Acevedo, Ivonne Pamela, Botana, Laura, Cruz, Israel, Boité, Mariana Côrtes, Moreno, Javier, Jeddi, Fakhn
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/31445
Resumo:	Institut Pasteur. Bioinformatics and Biostatistics Hub. Paris, France / Institute Pasteur. Unité de Parasitologiemoléculaire et Signalisation. Paris, France.

Metadados do item

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oai_identifier_str	oai:www.arca.fiocruz.br:icict/31445
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Bussotti, GiovanniGouzelou, EviAoun, KarimBouratbine, AïdaCupolillo, ElisaSpäthb, Gerald F.Kherachi, IhcenHarrat, ZoubirEddaikra, NaouelMottran, Jeremy C.Antoniou, MariaChristodoulou, VasilikiBali, AymenGuerfali, Fatima Z.Laouini, DhaferMukhtar, MaowiaDumetz, FranckDujardim, Jean-ClaudeSmirlis, DespinaLechar, PierrePescher, PascaleEl Hamouchi, AdilLemrani, MeryemChicharro, CarmenLlanes-Acevedo, Ivonne PamelaBotana, LauraCruz, IsraelBoité, Mariana CôrtesMoreno, JavierJeddi, Fakhn2019-02-06T12:10:14Z2019-02-06T12:10:14Z2018BUSSOTTI, Giovanni et al. Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation. mBio, v. 9, n. 6, p. 1-18, Nov./ Dez. 2018.2150-7511https://www.arca.fiocruz.br/handle/icict/3144510.1128/mBio.01399-18engAmerican Society for MicrobiologyLeishmaniaEvoluçãoVariação do número da cópia do geneAdaptação genômicaAneuploidiaAmplificação de TelômetosLieshmaniaEvolutionGene copy number variationGenomic adaptationTelomeric ampliﬁcationAneuploidyAneuploidiaLeishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstitut Pasteur. Bioinformatics and Biostatistics Hub. Paris, France / Institute Pasteur. Unité de Parasitologiemoléculaire et Signalisation. Paris, France.Institute Pasteur. Unité de Parasitologiemoléculaire et Signalisation. Paris, France.Institut Pasteur d’Algérie. Laboratoire d’Eco-épidémiologieparasitaire et Génétique des Populations, Algiers, Algéria.Institut Pasteur d’Algérie. Laboratoire d’Eco-épidémiologieparasitaire et Génétique des Populations, Algiers, Algéria.Institut Pasteur d’Algérie. Laboratoire d’Eco-épidémiologieparasitaire et Génétique des Populations, Algiers, Algéria.University of New York. Department of Biology. Centre for Immunology and Infection. New York, NY, USA.Laboratory of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine. School of Medicine, University of Crete. VassilikaVouton, Heraklion, Greece.Laboratory of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine. School of Medicine, University of Crete. VassilikaVouton, Heraklion, Greece.Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia / Université Tunis El Manar, Tunis, Tunisia.Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia / Université Tunis El Manar, Tunis, Tunisia.Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia / Université Tunis El Manar, Tunis, Tunisia.The Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.Institute of Tropical Medicine. Molecular Parasitology Unit, Antwerp, Belgium.Institute of Tropical Medicine. Molecular Parasitology Unit, Antwerp, Belgium / University of Antwerp. Department of Biomedical Sciences. Antwerp, Belgium.Hellenic Pasteur Institute. Molecular Parasitology Laboratory, Microbiology Department. Athens, Greece.Institut Pasteur—Bioinformatics and Biostatistics Hub—C3BI, USR 3756 IP CNRS, Paris, France.Unité de Parasitologiemoléculaire et Signalisation, Institut Pasteur, Paris, France.Laboratory of Parasitology and Vector-Borne-Diseases, Institut Pasteur du Maroc, Casablanca, Morocco.Laboratory of Parasitology and Vector-Borne-Diseases, Institut Pasteur du Marocco, Casablanca, Morocco.WHO Collaborating Centre for Leishmaniasis, Instituto de Salud Carlos III. Madrid, Spain.WHO Collaborating Centre for Leishmaniasis, Instituto de Salud Carlos III. Madrid, Spain.WHO Collaborating Centre for Leishmaniasis, Instituto de Salud Carlos III. Madrid, Spain.WHO Collaborating Centre for Leishmaniasis, Instituto de Salud Carlos III. Madrid, Spain.WHO Collaborating Centre for Leishmaniasis, Instituto de Salud Carlos III. Madrid, Spain.Université Tunis El Manar, Tunis, Tunisia / Research Laboratory Medical Parasitology, Biotechnology and Biomolecules, Institut Pasteur de Tunis. Tunis-Belvédère, Tunisia.Université Tunis El Manar, Tunis, Tunisia / Research Laboratory Medical Parasitology, Biotechnology and Biomolecules, Institut Pasteur de Tunis. Tunis-Belvédère, Tunisia.Université Tunis El Manar, Tunis, Tunisia / Research Laboratory Medical Parasitology, Biotechnology and Biomolecules, Institut Pasteur de Tunis. Tunis-Belvédère, Tunisia.Institut Pasteur. Unité de Parasitologiemoléculaire et Signalisation, Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Oruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.Protozoan parasites of the genus Leishmania adapt to environmental change through chromosome and gene copy number variations. Only little is known about external or intrinsic factors that govern Leishmania genomic adaptation. Here, by conducting longitudinal genome analyses of 10 new Leishmania clinical isolates, we uncovered important differences in gene copy number among genetically highly related strains and revealed gain and loss of gene copies as potential drivers of long-term environmental adaptation in the ﬁeld. In contrast, chromosome rather than gene ampliﬁcation was associated with short-term environmental adaptation to in vitro culture. Karyotypic solutions were highly reproducible but unique for a given strain, suggesting that chromosome ampliﬁcation is under positive selection and dependent on species- and strain-speciﬁc intrinsic factors. We revealed a progressive increase in read depth towards the chromosome ends for various Leishmania isolates, which may represent a nonclassical mechanism of telomere maintenance that can preserve integrity of chromosome ends during selection for fast in vitro growth. Together our data draw a complex picture of Leishmania genomic adaptation in the ﬁeld and in culture, which is driven by a combination of intrinsic genetic factors that generate strain-speciﬁc phenotypic variations, which are under environmental selection and allow for ﬁtness gain.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31445/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarianaboite_elisacupolillo_etal_IOC_2018.pdfmarianaboite_elisacupolillo_etal_IOC_2018.pdfapplication/pdf4298318https://www.arca.fiocruz.br/bitstream/icict/31445/2/marianaboite_elisacupolillo_etal_IOC_2018.pdf20c05a802c36e882cf2ddbeeb4fb4e35MD52TEXTmarianaboite_elisacupolillo_etal_IOC_2018.pdf.txtmarianaboite_elisacupolillo_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation
title	Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation
spellingShingle	Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation Bussotti, Giovanni Leishmania Evolução Variação do número da cópia do gene Adaptação genômica Aneuploidia Amplificação de Telômetos Lieshmania Evolution Gene copy number variation Genomic adaptation Telomeric ampliﬁcation Aneuploidy Aneuploidia
title_short	Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation
title_full	Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation
title_fullStr	Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation
title_full_unstemmed	Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation
title_sort	Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation
author	Bussotti, Giovanni
author_facet	Bussotti, Giovanni Gouzelou, Evi Aoun, Karim Bouratbine, Aïda Cupolillo, Elisa Späthb, Gerald F. Kherachi, Ihcen Harrat, Zoubir Eddaikra, Naouel Mottran, Jeremy C. Antoniou, Maria Christodoulou, Vasiliki Bali, Aymen Guerfali, Fatima Z. Laouini, Dhafer Mukhtar, Maowia Dumetz, Franck Dujardim, Jean-Claude Smirlis, Despina Lechar, Pierre Pescher, Pascale El Hamouchi, Adil Lemrani, Meryem Chicharro, Carmen Llanes-Acevedo, Ivonne Pamela Botana, Laura Cruz, Israel Boité, Mariana Côrtes Moreno, Javier Jeddi, Fakhn
author_role	author
author2	Gouzelou, Evi Aoun, Karim Bouratbine, Aïda Cupolillo, Elisa Späthb, Gerald F. Kherachi, Ihcen Harrat, Zoubir Eddaikra, Naouel Mottran, Jeremy C. Antoniou, Maria Christodoulou, Vasiliki Bali, Aymen Guerfali, Fatima Z. Laouini, Dhafer Mukhtar, Maowia Dumetz, Franck Dujardim, Jean-Claude Smirlis, Despina Lechar, Pierre Pescher, Pascale El Hamouchi, Adil Lemrani, Meryem Chicharro, Carmen Llanes-Acevedo, Ivonne Pamela Botana, Laura Cruz, Israel Boité, Mariana Côrtes Moreno, Javier Jeddi, Fakhn
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Bussotti, Giovanni Gouzelou, Evi Aoun, Karim Bouratbine, Aïda Cupolillo, Elisa Späthb, Gerald F. Kherachi, Ihcen Harrat, Zoubir Eddaikra, Naouel Mottran, Jeremy C. Antoniou, Maria Christodoulou, Vasiliki Bali, Aymen Guerfali, Fatima Z. Laouini, Dhafer Mukhtar, Maowia Dumetz, Franck Dujardim, Jean-Claude Smirlis, Despina Lechar, Pierre Pescher, Pascale El Hamouchi, Adil Lemrani, Meryem Chicharro, Carmen Llanes-Acevedo, Ivonne Pamela Botana, Laura Cruz, Israel Boité, Mariana Côrtes Moreno, Javier Jeddi, Fakhn
dc.subject.other.pt_BR.fl_str_mv	Leishmania Evolução Variação do número da cópia do gene Adaptação genômica Aneuploidia Amplificação de Telômetos
topic	Leishmania Evolução Variação do número da cópia do gene Adaptação genômica Aneuploidia Amplificação de Telômetos Lieshmania Evolution Gene copy number variation Genomic adaptation Telomeric ampliﬁcation Aneuploidy Aneuploidia
dc.subject.en.pt_BR.fl_str_mv	Lieshmania Evolution Gene copy number variation Genomic adaptation Telomeric ampliﬁcation Aneuploidy
dc.subject.decs.pt_BR.fl_str_mv	Aneuploidia
description	Institut Pasteur. Bioinformatics and Biostatistics Hub. Paris, France / Institute Pasteur. Unité de Parasitologiemoléculaire et Signalisation. Paris, France.
publishDate	2018
dc.date.issued.fl_str_mv	2018
dc.date.accessioned.fl_str_mv	2019-02-06T12:10:14Z
dc.date.available.fl_str_mv	2019-02-06T12:10:14Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	BUSSOTTI, Giovanni et al. Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation. mBio, v. 9, n. 6, p. 1-18, Nov./ Dez. 2018.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/31445
dc.identifier.issn.pt_BR.fl_str_mv	2150-7511
dc.identifier.doi.pt_BR.fl_str_mv	10.1128/mBio.01399-18
identifier_str_mv	BUSSOTTI, Giovanni et al. Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation. mBio, v. 9, n. 6, p. 1-18, Nov./ Dez. 2018. 2150-7511 10.1128/mBio.01399-18
url	https://www.arca.fiocruz.br/handle/icict/31445
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	American Society for Microbiology
publisher.none.fl_str_mv	American Society for Microbiology
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Speciﬁc Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Ampliﬁcation

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