Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/34840 |
Resumo: | Universidade Federal do Paraná. Programa de Pós-Graduação em Medicina Interna e Ciências da Saúde. Curitiba, PR, Brasil. |
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Oliveira-Netto, Ana Cristina Schmidt deMorello, Luis GustavoDalla-Costa, Líbera MariaPetterle, Ricardo RasmussenFontana, Rafael MialskiConte, DanieliPereira, Luciane AparecidaRaboni, Sonia Mara2019-08-15T18:21:16Z2019-08-15T18:21:16Z2019OLIVEIRA-NETTO, Ana Cristina Schmidt de et al. Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis. Clinical Pathology, v. 12, p. 1-7, 2019.2632-010Xhttps://www.arca.fiocruz.br/handle/icict/3484010.1177/2632010X198476732632-010XporSAGE PublishingEpidemiologiaSepsisBiomarkersProcalcitoninC-Reactive ProteinEpidemiologySepsisBiomarcadoresPolipéptido alfa Relacionado con CalcitoninaProteína C-ReactivaEpidemiologíaSepseBiomarcadoresPró-CalcitoninaProteína C-ReativaProcalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Programa de Pós-Graduação em Medicina Interna e Ciências da Saúde. Curitiba, PR, Brasil.Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciencias e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Universidade Federal do Paraná. Laboratório de Bacteriologia. Curitiba, PR, Brasil / Faculdades e Instituto de Pesquisa Pelé Pequeno Príncipe. Curitiba, PR, Brasil.Universidade Federal do Paraná. Setor de Ciências da Saúde. Curitiba, PR, Brasil.Universidade Federal do Paraná. Divisão de Doenças Infecciosas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciencias e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciencias e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Universidade Federal do Paraná. Programa de Pós-Graduação em Medicina Interna e Ciências da Saúde. Curitiba, PR, Brasil / Universidade Federal do Paraná. Divisão de Doenças Infecciosas. Curitiba, PR, Brasil.Sepsis is a condition with high mortality rates and its diagnosis remains a challenge. We assessed epidemiological, clinical data, multiple biomarker profiles, and blood culture with respect to sepsis diagnosis and predictors of outcome. As methods, it had a total, 183 patients who were suspected of having sepsis and underwent blood culture collection were followed up for 7 days. Sepsis-related Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II scores were calculated daily; biomarkers and blood culture test results were evaluated. As Results it had: In total, 78 (43%) had sepsis, 50 (27%) had septic shock, and 55 (30%) had no sepsis. Blood culture was positive in 28% and 42% of the sepsis and septic shock groups, respectively (P < .001). Regarding clinical profiles and biomarker values, there were no differences between the sepsis and non-sepsis groups, but significant differences were observed in the septic shock group. Multivariate logistic regression models revealed that age, serum albumin level, APACHE II, and SOFA 1st day scores were the independent variables for death. Thus we conclude that, the challenge in the diagnosis of sepsis continues as clinical and laboratory differences found between the groups were due to septic shock. Older aged patients with lower albumin levels and higher APACHE II and SOFA 1st day scores have a greater probability of mortality.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/34840/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINAL2632010x198476.pdf2632010x198476.pdfapplication/pdf317094https://www.arca.fiocruz.br/bitstream/icict/34840/2/2632010x198476.pdfd1de01e0ec4fe2bcc7869691757145e9MD52TEXT2632010x198476.pdf.txt2632010x198476.pdf.txtExtracted texttext/plain31673https://www.arca.fiocruz.br/bitstream/icict/34840/3/2632010x198476.pdf.txtaba73160f0c83f39ce013625f63bdbeeMD53icict/348402019-10-31 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| dc.title.pt_BR.fl_str_mv |
Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis |
| title |
Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis |
| spellingShingle |
Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis Oliveira-Netto, Ana Cristina Schmidt de Epidemiologia Sepsis Biomarkers Procalcitonin C-Reactive Protein Epidemiology Sepsis Biomarcadores Polipéptido alfa Relacionado con Calcitonina Proteína C-Reactiva Epidemiología Sepse Biomarcadores Pró-Calcitonina Proteína C-Reativa |
| title_short |
Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis |
| title_full |
Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis |
| title_fullStr |
Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis |
| title_full_unstemmed |
Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis |
| title_sort |
Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis |
| author |
Oliveira-Netto, Ana Cristina Schmidt de |
| author_facet |
Oliveira-Netto, Ana Cristina Schmidt de Morello, Luis Gustavo Dalla-Costa, Líbera Maria Petterle, Ricardo Rasmussen Fontana, Rafael Mialski Conte, Danieli Pereira, Luciane Aparecida Raboni, Sonia Mara |
| author_role |
author |
| author2 |
Morello, Luis Gustavo Dalla-Costa, Líbera Maria Petterle, Ricardo Rasmussen Fontana, Rafael Mialski Conte, Danieli Pereira, Luciane Aparecida Raboni, Sonia Mara |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira-Netto, Ana Cristina Schmidt de Morello, Luis Gustavo Dalla-Costa, Líbera Maria Petterle, Ricardo Rasmussen Fontana, Rafael Mialski Conte, Danieli Pereira, Luciane Aparecida Raboni, Sonia Mara |
| dc.subject.other.pt_BR.fl_str_mv |
Epidemiologia |
| topic |
Epidemiologia Sepsis Biomarkers Procalcitonin C-Reactive Protein Epidemiology Sepsis Biomarcadores Polipéptido alfa Relacionado con Calcitonina Proteína C-Reactiva Epidemiología Sepse Biomarcadores Pró-Calcitonina Proteína C-Reativa |
| dc.subject.en.pt_BR.fl_str_mv |
Sepsis Biomarkers Procalcitonin C-Reactive Protein Epidemiology |
| dc.subject.es.pt_BR.fl_str_mv |
Sepsis Biomarcadores Polipéptido alfa Relacionado con Calcitonina Proteína C-Reactiva Epidemiología |
| dc.subject.decs.pt_BR.fl_str_mv |
Sepse Biomarcadores Pró-Calcitonina Proteína C-Reativa |
| description |
Universidade Federal do Paraná. Programa de Pós-Graduação em Medicina Interna e Ciências da Saúde. Curitiba, PR, Brasil. |
| publishDate |
2019 |
| dc.date.accessioned.fl_str_mv |
2019-08-15T18:21:16Z |
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2019-08-15T18:21:16Z |
| dc.date.issued.fl_str_mv |
2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
OLIVEIRA-NETTO, Ana Cristina Schmidt de et al. Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis. Clinical Pathology, v. 12, p. 1-7, 2019. |
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https://www.arca.fiocruz.br/handle/icict/34840 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2632-010X |
| dc.identifier.doi.none.fl_str_mv |
10.1177/2632010X19847673 |
| dc.identifier.eissn.none.fl_str_mv |
2632-010X |
| identifier_str_mv |
OLIVEIRA-NETTO, Ana Cristina Schmidt de et al. Procalcitonin, c-reactive protein, albumin, and blood cultures as early markers of sepsis diagnosis or predictors of outcome: a prospective analysis. Clinical Pathology, v. 12, p. 1-7, 2019. 2632-010X 10.1177/2632010X19847673 |
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SAGE Publishing |
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SAGE Publishing |
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