Clinical and laboratory signs associated to serious dengue disease in hospitalized children
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.jped.2015.12.005 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32141 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. |
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Pone, Sheila MouraHökerberg, Yara Hahr MarquesOliveira, Raquel de Vasconcellos Carvalhaes deDaumas, Regina PaivaPone, Tamiris MouraPone, Marcos Vinicius da SilvaBrasil, Patricia2019-03-19T11:53:57Z2019-03-19T11:53:57Z2016PONE, Sheila Moura et al. Clinical and laboratory signs associated to serious dengue disease in hospitalized children. Jornal de Pediatria, Rio de Janeiro, v. 92, n. 5, p. 464-471, 2016.0021-7557https://www.arca.fiocruz.br/handle/icict/3214110.1016/j.jped.2015.12.0051678-4782engSociedade Brasileira de PediatriaDengueCriançasSensibilidade e especificidadeEstudos de validaçãoDengueChildrenSensitivity and specificityValidation studiesClinical and laboratory signs associated to serious dengue disease in hospitalized childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Objective: To evaluate the validity of clinical and laboratory signs to serious dengue disease in hospitalized children. Methods: Retrospective cohort of children (<18 years) hospitalized with dengue diagnosis (2007---2008). Serious dengue disease was defined as death or use of advanced life support therapy. Accuracy measures and area under the receiver operating characteristic curve were calculated. Results: Of the total (n = 145), 53.1% were female, 69% aged 2---11 years, and 15.9% evolved to the worse outcome. Lethargy had the best accuracy (positive likelihood ratio >19 and negative likelihood ratio <0.6). Pleural effusion and abdominal distension had higher sensitivity (82.6%). History of bleeding (epistaxis, gingival or gastrointestinal bleeding) and severe hemorrhage (pulmonary or gastrointestinal bleeding) in physical examination were more frequent in serious dengue disease (p < 0.01), but with poor accuracy (positive likelihood ratio = 1.89 and 3.89; negative likelihood ratio = 0.53 and 0.60, respectively). Serum albumin was lower in serious dengue forms (p < 0.01). Despite statistical significance (p < 0.05), both groups presented thrombocytopenia. Platelets count, hematocrit, and hemoglobin parameters had area under the curve <0.5. Conclusions: Lethargy, abdominal distension, pleural effusion, and hypoalbuminemia were the best clinical and laboratorial markers of serious dengue disease in hospitalized children, while bleeding, severe hemorrhage, hemoconcentration and thrombocytopenia did not reach adequate diagnostic accuracy. In pediatric referral hospitals, the absence of hemoconcentration does not imply absence of plasma leakage, particularly in children with previous fluid replacement. These findings may contribute to the clinical management of dengue in children at referral hospitals.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32141/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALsheilamoura_pone_etal_IOC_2016.pdfsheilamoura_pone_etal_IOC_2016.pdfapplication/pdf569085https://www.arca.fiocruz.br/bitstream/icict/32141/2/sheilamoura_pone_etal_IOC_2016.pdfef82a450ea446060f4968dfa48c6a038MD52TEXTsheilamoura_pone_etal_IOC_2016.pdf.txtsheilamoura_pone_etal_IOC_2016.pdf.txtExtracted texttext/plain36228https://www.arca.fiocruz.br/bitstream/icict/32141/3/sheilamoura_pone_etal_IOC_2016.pdf.txt283f13fc10b67f3363618361f797e202MD53icict/321412019-05-06 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| dc.title.pt_BR.fl_str_mv |
Clinical and laboratory signs associated to serious dengue disease in hospitalized children |
| title |
Clinical and laboratory signs associated to serious dengue disease in hospitalized children |
| spellingShingle |
Clinical and laboratory signs associated to serious dengue disease in hospitalized children Pone, Sheila Moura Dengue Crianças Sensibilidade e especificidade Estudos de validação Dengue Children Sensitivity and specificity Validation studies |
| title_short |
Clinical and laboratory signs associated to serious dengue disease in hospitalized children |
| title_full |
Clinical and laboratory signs associated to serious dengue disease in hospitalized children |
| title_fullStr |
Clinical and laboratory signs associated to serious dengue disease in hospitalized children |
| title_full_unstemmed |
Clinical and laboratory signs associated to serious dengue disease in hospitalized children |
| title_sort |
Clinical and laboratory signs associated to serious dengue disease in hospitalized children |
| author |
Pone, Sheila Moura |
| author_facet |
Pone, Sheila Moura Hökerberg, Yara Hahr Marques Oliveira, Raquel de Vasconcellos Carvalhaes de Daumas, Regina Paiva Pone, Tamiris Moura Pone, Marcos Vinicius da Silva Brasil, Patricia |
| author_role |
author |
| author2 |
Hökerberg, Yara Hahr Marques Oliveira, Raquel de Vasconcellos Carvalhaes de Daumas, Regina Paiva Pone, Tamiris Moura Pone, Marcos Vinicius da Silva Brasil, Patricia |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Pone, Sheila Moura Hökerberg, Yara Hahr Marques Oliveira, Raquel de Vasconcellos Carvalhaes de Daumas, Regina Paiva Pone, Tamiris Moura Pone, Marcos Vinicius da Silva Brasil, Patricia |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Crianças Sensibilidade e especificidade Estudos de validação |
| topic |
Dengue Crianças Sensibilidade e especificidade Estudos de validação Dengue Children Sensitivity and specificity Validation studies |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue Children Sensitivity and specificity Validation studies |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. |
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2016 |
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2016 |
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2019-03-19T11:53:57Z |
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2019-03-19T11:53:57Z |
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PONE, Sheila Moura et al. Clinical and laboratory signs associated to serious dengue disease in hospitalized children. Jornal de Pediatria, Rio de Janeiro, v. 92, n. 5, p. 464-471, 2016. |
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https://www.arca.fiocruz.br/handle/icict/32141 |
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0021-7557 |
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10.1016/j.jped.2015.12.005 |
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1678-4782 |
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PONE, Sheila Moura et al. Clinical and laboratory signs associated to serious dengue disease in hospitalized children. Jornal de Pediatria, Rio de Janeiro, v. 92, n. 5, p. 464-471, 2016. 0021-7557 10.1016/j.jped.2015.12.005 1678-4782 |
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Sociedade Brasileira de Pediatria |
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Sociedade Brasileira de Pediatria |
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