The importance of RNA-based vaccines in the fight against COVID-19: an overview

Detalhes bibliográficos
Autor(a) principal: Machado, Bruna Aparecida Souza
Data de Publicação: 2021
Outros Autores: Hodel, Katharine Valéria Saraiva, Fonseca, Larissa Moraes dos Santos, Mascarenhas, Luís Alberto Brêda, Andrade, Leone Peter Correia da Silva, Rocha, Vinícius Pinto Costa, Soares, Milena Botelho Pereira, Berglund, Peter, Duthie, Malcolm S, Reed, Steven G, Badaró, Roberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51159
Resumo: Instituto SENAI de Sistemas Avançados de Saúde. Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.
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spelling Machado, Bruna Aparecida SouzaHodel, Katharine Valéria SaraivaFonseca, Larissa Moraes dos SantosMascarenhas, Luís Alberto BrêdaAndrade, Leone Peter Correia da SilvaRocha, Vinícius Pinto CostaSoares, Milena Botelho PereiraBerglund, PeterDuthie, Malcolm SReed, Steven GBadaró, Roberto2022-02-11T17:26:19Z2022-02-11T17:26:19Z2021MACHADO, Bruna Aparecida Souza et al. The importance of RNA-based vaccines in the fight against COVID-19: an overview. Vaccines, v. 9, n. 11, p. 1-38, 2021.2076-393Xhttps://www.arca.fiocruz.br/handle/icict/5115910.3390/vaccines9111345engMDPICOVID-19VacinasRNARNA MensageiroCOVID-19VaccinesRNARNA MessengerThe importance of RNA-based vaccines in the fight against COVID-19: an overviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto SENAI de Sistemas Avançados de Saúde. Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.Instituto SENAI de Sistemas Avançados de Saúde. Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.Instituto SENAI de Sistemas Avançados de Saúde. Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.Instituto SENAI de Sistemas Avançados de Saúde. Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.Instituto SENAI de Sistemas Avançados de Saúde. Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.Instituto SENAI de Sistemas Avançados de Saúde. Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.Instituto SENAI de Sistemas Avançados de Saúde. Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil / Fundação Oswaldo Cruz, Instituto Gonçalo Moniz. Salvador, BA, Brasil.HDT Bio. Seattle, WA, USA.HDT Bio. Seattle, WA, USA.HDT Bio. Seattle, WA, USA.Instituto SENAI de Sistemas Avançados de Saúde. Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.In recent years, vaccine development using ribonucleic acid (RNA) has become the most promising and studied approach to produce safe and effective new vaccines, not only for prophylaxis but also as a treatment. The use of messenger RNA (mRNA) as an immunogenic has several advantages to vaccine development compared to other platforms, such as lower coast, the absence of cell cultures, and the possibility to combine different targets. During the COVID-19 pandemic, the use of mRNA as a vaccine became more relevant; two out of the four most widely applied vaccines against COVID-19 in the world are based on this platform. However, even though it presents advantages for vaccine application, mRNA technology faces several pivotal challenges to improve mRNA stability, delivery, and the potential to generate the related protein needed to induce a humoral- and T-cell-mediated immune response. The application of mRNA to vaccine development emerged as a powerful tool to fight against cancer and non-infectious and infectious diseases, for example, and represents a relevant research field for future decades. Based on these advantages, this review emphasizes mRNA and self-amplifying RNA (saRNA) for vaccine development, mainly to fight against COVID-19, together with the challenges related to this approach.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51159/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMachado Bruna etal - The Importance of RNA-Based Vaccines.pdfMachado Bruna etal - The Importance of RNA-Based Vaccines.pdfapplication/pdf1666247https://www.arca.fiocruz.br/bitstream/icict/51159/2/Machado%20Bruna%20etal%20-%20The%20Importance%20of%20RNA-Based%20Vaccines.pdfecd685d4f2571edd298d7b4a26af5899MD52icict/511592023-03-15 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dc.title.pt_BR.fl_str_mv The importance of RNA-based vaccines in the fight against COVID-19: an overview
title The importance of RNA-based vaccines in the fight against COVID-19: an overview
spellingShingle The importance of RNA-based vaccines in the fight against COVID-19: an overview
Machado, Bruna Aparecida Souza
COVID-19
Vacinas
RNA
RNA Mensageiro
COVID-19
Vaccines
RNA
RNA Messenger
title_short The importance of RNA-based vaccines in the fight against COVID-19: an overview
title_full The importance of RNA-based vaccines in the fight against COVID-19: an overview
title_fullStr The importance of RNA-based vaccines in the fight against COVID-19: an overview
title_full_unstemmed The importance of RNA-based vaccines in the fight against COVID-19: an overview
title_sort The importance of RNA-based vaccines in the fight against COVID-19: an overview
author Machado, Bruna Aparecida Souza
author_facet Machado, Bruna Aparecida Souza
Hodel, Katharine Valéria Saraiva
Fonseca, Larissa Moraes dos Santos
Mascarenhas, Luís Alberto Brêda
Andrade, Leone Peter Correia da Silva
Rocha, Vinícius Pinto Costa
Soares, Milena Botelho Pereira
Berglund, Peter
Duthie, Malcolm S
Reed, Steven G
Badaró, Roberto
author_role author
author2 Hodel, Katharine Valéria Saraiva
Fonseca, Larissa Moraes dos Santos
Mascarenhas, Luís Alberto Brêda
Andrade, Leone Peter Correia da Silva
Rocha, Vinícius Pinto Costa
Soares, Milena Botelho Pereira
Berglund, Peter
Duthie, Malcolm S
Reed, Steven G
Badaró, Roberto
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Machado, Bruna Aparecida Souza
Hodel, Katharine Valéria Saraiva
Fonseca, Larissa Moraes dos Santos
Mascarenhas, Luís Alberto Brêda
Andrade, Leone Peter Correia da Silva
Rocha, Vinícius Pinto Costa
Soares, Milena Botelho Pereira
Berglund, Peter
Duthie, Malcolm S
Reed, Steven G
Badaró, Roberto
dc.subject.other.pt_BR.fl_str_mv COVID-19
Vacinas
RNA
RNA Mensageiro
topic COVID-19
Vacinas
RNA
RNA Mensageiro
COVID-19
Vaccines
RNA
RNA Messenger
dc.subject.en.pt_BR.fl_str_mv COVID-19
Vaccines
RNA
RNA Messenger
description Instituto SENAI de Sistemas Avançados de Saúde. Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-11T17:26:19Z
dc.date.available.fl_str_mv 2022-02-11T17:26:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACHADO, Bruna Aparecida Souza et al. The importance of RNA-based vaccines in the fight against COVID-19: an overview. Vaccines, v. 9, n. 11, p. 1-38, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51159
dc.identifier.issn.pt_BR.fl_str_mv 2076-393X
dc.identifier.doi.none.fl_str_mv 10.3390/vaccines9111345
identifier_str_mv MACHADO, Bruna Aparecida Souza et al. The importance of RNA-based vaccines in the fight against COVID-19: an overview. Vaccines, v. 9, n. 11, p. 1-38, 2021.
2076-393X
10.3390/vaccines9111345
url https://www.arca.fiocruz.br/handle/icict/51159
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51159/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51159/2/Machado%20Bruna%20etal%20-%20The%20Importance%20of%20RNA-Based%20Vaccines.pdf
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