Challenges in the research and development of new human vaccines

Detalhes bibliográficos
Autor(a) principal: Bessa, Theolis Costa Barbosa
Data de Publicação: 2013
Outros Autores: Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7261
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
id CRUZ_05285cb71ccb30c5e5d67f597d7b2db7
oai_identifier_str oai:www.arca.fiocruz.br:icict/7261
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Bessa, Theolis Costa BarbosaBarral Netto, Manoel2013-11-25T19:29:46Z2013-11-25T19:29:46Z2013BARBOSA, T.; BARBOSA, T. Challenges in the research and development of new human vaccines. Brazilian Journal of Medical and Biological Research, v. 46, n. 2, p.103-108, 2013.1414-431Xhttps://www.arca.fiocruz.br/handle/icict/726110.1590/1414-431X20131873engFaculdade de Medicina de Ribeirao PretoChallenges in the research and development of new human vaccinesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilThe field of vaccinology was born from the observations by the fathers of vaccination, Edward Jenner and Louis Pasteur, that a permanent, positive change in the way our bodies respond to life-threatening infectious diseases can be obtained by specific challenge with the inactivated infectious agent performed in a controlled manner, avoiding the development of clinical disease upon exposure to the virulent pathogen. Many of the vaccines still in use today were developed on an empirical basis, essentially following the paradigm established by Pasteur, ‘‘isolate, inactivate, and inject’’ the disease-causing microorganism, and are capable of eliciting uniform, long-term immune memory responses that constitute the key to their proven efficacy. However, vaccines for pathogens considered as priority targets of public health concern are still lacking. The literature tends to focus more often on vaccine research problems associated with specific pathogens, but it is increasingly clear that there are common bottlenecks in vaccine research, which need to be solved in order to advance the development of the field as a whole. As part of a group of articles, the objective of the present report is to pinpoint these bottlenecks, exploring the literature for common problems and solutions in vaccine research applied to different situations. Our goal is to stimulate brainstorming among specialists of different fields related to vaccine research and development. Here, we briefly summarize the topics we intend to deal with in this discussion.Human vaccinesVaccine issuesVaccine efficacyImmunization strategiesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarbosa T Challenges in the....pdfBarbosa T Challenges in the....pdfapplication/pdf210220https://www.arca.fiocruz.br/bitstream/icict/7261/1/Barbosa%20T%20Challenges%20in%20the....pdfa3500b1dd61d3123c0b596b7594c3fdbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7261/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBarbosa T Challenges in the....pdf.txtBarbosa T Challenges in the....pdf.txtExtracted texttext/plain31917https://www.arca.fiocruz.br/bitstream/icict/7261/5/Barbosa%20T%20Challenges%20in%20the....pdf.txtc291243be41e6e465e02a6038792de56MD55THUMBNAILBarbosa T Challenges in the....pdf.jpgBarbosa T Challenges in the....pdf.jpgGenerated Thumbnailimage/jpeg2156https://www.arca.fiocruz.br/bitstream/icict/7261/4/Barbosa%20T%20Challenges%20in%20the....pdf.jpg97a1fd65137db737f35319e554a9898bMD54icict/72612023-03-15 14:32:53.857oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Challenges in the research and development of new human vaccines
title Challenges in the research and development of new human vaccines
spellingShingle Challenges in the research and development of new human vaccines
Bessa, Theolis Costa Barbosa
Human vaccines
Vaccine issues
Vaccine efficacy
Immunization strategies
title_short Challenges in the research and development of new human vaccines
title_full Challenges in the research and development of new human vaccines
title_fullStr Challenges in the research and development of new human vaccines
title_full_unstemmed Challenges in the research and development of new human vaccines
title_sort Challenges in the research and development of new human vaccines
author Bessa, Theolis Costa Barbosa
author_facet Bessa, Theolis Costa Barbosa
Barral Netto, Manoel
author_role author
author2 Barral Netto, Manoel
author2_role author
dc.contributor.author.fl_str_mv Bessa, Theolis Costa Barbosa
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Human vaccines
Vaccine issues
Vaccine efficacy
Immunization strategies
topic Human vaccines
Vaccine issues
Vaccine efficacy
Immunization strategies
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-11-25T19:29:46Z
dc.date.available.fl_str_mv 2013-11-25T19:29:46Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARBOSA, T.; BARBOSA, T. Challenges in the research and development of new human vaccines. Brazilian Journal of Medical and Biological Research, v. 46, n. 2, p.103-108, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7261
dc.identifier.issn.none.fl_str_mv 1414-431X
dc.identifier.doi.none.fl_str_mv 10.1590/1414-431X20131873
identifier_str_mv BARBOSA, T.; BARBOSA, T. Challenges in the research and development of new human vaccines. Brazilian Journal of Medical and Biological Research, v. 46, n. 2, p.103-108, 2013.
1414-431X
10.1590/1414-431X20131873
url https://www.arca.fiocruz.br/handle/icict/7261
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Faculdade de Medicina de Ribeirao Preto
publisher.none.fl_str_mv Faculdade de Medicina de Ribeirao Preto
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7261/1/Barbosa%20T%20Challenges%20in%20the....pdf
https://www.arca.fiocruz.br/bitstream/icict/7261/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/7261/5/Barbosa%20T%20Challenges%20in%20the....pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/7261/4/Barbosa%20T%20Challenges%20in%20the....pdf.jpg
bitstream.checksum.fl_str_mv a3500b1dd61d3123c0b596b7594c3fdb
7d48279ffeed55da8dfe2f8e81f3b81f
c291243be41e6e465e02a6038792de56
97a1fd65137db737f35319e554a9898b
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009237589098496

Registros relacionados