Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil

Detalhes bibliográficos
Autor(a) principal: Nunes, Patrícia Silva
Data de Publicação: 2021
Outros Autores: Guimarães, Rafael Alves, Martelli, Celina Maria Turchi, Souza, Wayner Vieira de, Turchi, Marília Dalva
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51465
Resumo: The study was approved by the Research Ethics Committee of the Federal University of Goiás (Protocol No. 3.057.525/2018). The study analysed public data, and therefore participant consent was not applicable. We confrm that all methods were carried out in accordance with relevant guidelines and regulations for the research article. This study was approved by the Research Ethics Committee of the Federal University of Goiás under Grant No. 3.057.525/2018. The study analysed public data, and therefore participant consent was not applicable.
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spelling Nunes, Patrícia SilvaGuimarães, Rafael AlvesMartelli, Celina Maria TurchiSouza, Wayner Vieira deTurchi, Marília Dalva2022-02-24T15:52:04Z2022-02-24T15:52:04Z2021NUNES, Patrícia Silva et al. Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil. BMC Infectious Diseases, v. 21, p. 1-14, 2021.1471-2334https://www.arca.fiocruz.br/handle/icict/5146510.1186/s12879-021-06805-1The study was approved by the Research Ethics Committee of the Federal University of Goiás (Protocol No. 3.057.525/2018). The study analysed public data, and therefore participant consent was not applicable. We confrm that all methods were carried out in accordance with relevant guidelines and regulations for the research article. This study was approved by the Research Ethics Committee of the Federal University of Goiás under Grant No. 3.057.525/2018. The study analysed public data, and therefore participant consent was not applicable.Federal Institute of Education. Science and Technology of Goiás. Goiânia, GO, Brazil / Federal University of Goiás. Institute of Tropical Pathology and Public Health. Goiânia, GO, Brazil.Federal University of Goiás. Institute of Tropical Pathology and Public Health. Goiânia, GO, Brazil / Federal University of Goiás. Faculty of Nursing. Goiânia, GO, Brazil.Oswaldo Cruz Foundation. Instituto Aggeu Magalhães. Recife, PE, Brazil.Oswaldo Cruz Foundation. Instituto Aggeu Magalhães. Recife, PE, Brazil.Federal University of Goiás. Institute of Tropical Pathology and Public Health. Goiânia, GO, Brazil.Background: More than 5 years after the Zika virus (ZIKV) epidemic, Zika infection remains a major concern in regions with high Aedes infestation. The objectives of this study were (i) to identify clusters of ZIKV infection and microcephaly, and/or central nervous system (CNS) alterations associated with congenital infection during the epidemic peak in 2016 and subsequently, in 2017 and 2018; (ii) to measure the non-spatial correlation between ZIKV infection and microcephaly and/or CNS alterations associated with congenital infection; and (iii) to analyse the sociodemographic/economic, health, and environmental determinants associated with the incidence of ZIKV in a region of high infestation by Aedes aegypti in the Central-West Region of Brazil. Methods: This ecological study analysed 246 municipalities in the state of Goiás (6.9 million inhabitants). The data were obtained from the Information System for Notifable Diseases (ZIKV cases) and the Public Health Event Registry (microcephaly and/or CNS alterations associated with congenital infection). Incidence rates and prevalence of ZIKA infection were smoothed by an empirical Bayesian estimator (LEbayes), producing the local empirical Bayesian rate (LEBR). In the spatial analysis, ZIKV infection and microcephaly cases were georeferenced by the municipality of residence for 2016 and grouped for 2017 and 2018. Global Moran’s I and the Hot Spot Analysis tool (Getis-Ord Gi* statistics) were used to analyse the spatial autocorrelation and clusters of ZIKV infection and microcephaly, respectively. A generalised linear model from the Poisson family was used to assess the association between ecological determinants and the smoothing incidence rate of ZIKV infection. Results: A total of 9892 cases of acute ZIKV infection and 121 cases of microcephaly were confrmed. The mean LEBR of the ZIKV infection in the 246 municipalities was 22.3 cases/100,000 inhabitants in 2016, and 10.3 cases/100,000 inhabitants in 2017 and 2018. The LEBR of the prevalence rate of microcephaly and/or CNS alterations associated with congenital infection was 7 cases/10,000 live births in 2016 and 2 cases/10,000 live births during 2017–2018. Hotspots of ZIKV infection and microcephaly cases were identifed in the capital and neighbouring municipalities in 2016, with new clusters in the following years. In a multiple regression Poisson analysis, ZIKV infection was associated with higher population density, the incidence of dengue, Aedes larvae infestation index, and average rainfall. The important determinant of ZIKV infection incidence reduction was the increase in households attended by endemic disease control agents. Conclusions: Our analyses were able to capture, in a more granular way, aspects that make it possible to inform public managers of the sentinel areas identifed in the post-epidemic hotspots.porAedesAnimalsArbovirusBayes TheoremBrazilHumansMicrocephalyPublic healthSocioeconomic statusSpatial analysisZika VirusZika Virus InfectionZika virusArbovirusSocioeconomic statusMicrocephalyPublic healthSpatial analysisBrazilZika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83088https://www.arca.fiocruz.br/bitstream/icict/51465/1/license.txt7b043faf2a6ad46e5344ca8d54801d8cMD51ORIGINALZika virus infection and microcephaly spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil.pdfZika virus infection and microcephaly spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil.pdfapplication/pdf8400007https://www.arca.fiocruz.br/bitstream/icict/51465/2/Zika%20virus%20infection%20and%20microcephaly%20spatial%20analysis%20and%20socio-environmental%20determinants%20in%20a%20region%20of%20high%20Aedes%20aegypti%20infestation%20in%20the%20Central-West%20Region%20of%20Brazil.pdfeb0581008acf4dc59951825539b31003MD52icict/514652022-02-28 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dc.title.pt_BR.fl_str_mv Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil
title Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil
spellingShingle Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil
Nunes, Patrícia Silva
Aedes
Animals
Arbovirus
Bayes Theorem
Brazil
Humans
Microcephaly
Public health
Socioeconomic status
Spatial analysis
Zika Virus
Zika Virus Infection
Zika virus
Arbovirus
Socioeconomic status
Microcephaly
Public health
Spatial analysis
Brazil
title_short Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil
title_full Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil
title_fullStr Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil
title_full_unstemmed Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil
title_sort Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil
author Nunes, Patrícia Silva
author_facet Nunes, Patrícia Silva
Guimarães, Rafael Alves
Martelli, Celina Maria Turchi
Souza, Wayner Vieira de
Turchi, Marília Dalva
author_role author
author2 Guimarães, Rafael Alves
Martelli, Celina Maria Turchi
Souza, Wayner Vieira de
Turchi, Marília Dalva
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Patrícia Silva
Guimarães, Rafael Alves
Martelli, Celina Maria Turchi
Souza, Wayner Vieira de
Turchi, Marília Dalva
dc.subject.mesh.pt_BR.fl_str_mv Aedes
Animals
Arbovirus
Bayes Theorem
Brazil
Humans
Microcephaly
Public health
Socioeconomic status
Spatial analysis
Zika Virus
Zika Virus Infection
topic Aedes
Animals
Arbovirus
Bayes Theorem
Brazil
Humans
Microcephaly
Public health
Socioeconomic status
Spatial analysis
Zika Virus
Zika Virus Infection
Zika virus
Arbovirus
Socioeconomic status
Microcephaly
Public health
Spatial analysis
Brazil
dc.subject.en.pt_BR.fl_str_mv Zika virus
Arbovirus
Socioeconomic status
Microcephaly
Public health
Spatial analysis
Brazil
description The study was approved by the Research Ethics Committee of the Federal University of Goiás (Protocol No. 3.057.525/2018). The study analysed public data, and therefore participant consent was not applicable. We confrm that all methods were carried out in accordance with relevant guidelines and regulations for the research article. This study was approved by the Research Ethics Committee of the Federal University of Goiás under Grant No. 3.057.525/2018. The study analysed public data, and therefore participant consent was not applicable.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-24T15:52:04Z
dc.date.available.fl_str_mv 2022-02-24T15:52:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv NUNES, Patrícia Silva et al. Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil. BMC Infectious Diseases, v. 21, p. 1-14, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51465
dc.identifier.issn.pt_BR.fl_str_mv 1471-2334
dc.identifier.doi.pt_BR.fl_str_mv 10.1186/s12879-021-06805-1
identifier_str_mv NUNES, Patrícia Silva et al. Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil. BMC Infectious Diseases, v. 21, p. 1-14, 2021.
1471-2334
10.1186/s12879-021-06805-1
url https://www.arca.fiocruz.br/handle/icict/51465
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