Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets

Detalhes bibliográficos
Autor(a) principal: Simões, Rachel Siqueira de Queiroz
Data de Publicação: 2015
Outros Autores: Barth, Ortrud Monika
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14438
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.
id CRUZ_063ca067778cc75fc688ce6a333dab9b
oai_identifier_str oai:www.arca.fiocruz.br:icict/14438
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Simões, Rachel Siqueira de QueirozBarth, Ortrud Monika2016-06-02T13:05:57Z2016-06-03T12:34:19Z2016-06-02T13:05:57Z2016-06-03T12:34:19Z2015SIMÕES, Rachel Siqueira de Queiroz; BARTH, Ortrud Monika. Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets. International Journal of Biomedical Research, v.6, n.10, p.763-768, 2015.2455-0566https://www.arca.fiocruz.br/handle/icict/1443810.7439/ijbr0976-9633engScholar Science JournalsPapilomavírusVectores virais e não viraisCromossomosTerapia de genesPapillomavirusViral and non-viral vectorChromosomesGene therapyPapillomavirus: Viral vectors in the gene therapy and new therapeutic targetsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Epitheliotropic and mucosotropic Papillomaviruses (PVs) constitute the Papillomaviridae family. There are 26 genera comprising levels of inter species genetic similarities by nucleotide sequence analysis of the L1 viral region, the generally most conserved region among papillomaviruses. There is an increasing consensus that the ideal vector for gene therapy should be completely based on chromosomal elements and behave as an independent functional unit after integration. The present paper is a short review about epidemiology of HPV infection, vaccines anti-HPV and tumors associated with HPV and gene therapy including biological vectors, stem cells, viral and non-viral vectors and chromosome-based vectors. Furthermore, new therapeutic targets and vectors applied in gene therapy of other viruses are some of the examples that have been successfully modified by recombinant DNA techniques. New biotechnologies in molecular biology have been applied in papillomavirus research and are still being investigated for the application in the gene therapy. RNA-sequencing (RNA-seq) for analysis of the transcriptome, multiply-primed rolling circle amplification (RCA) used to identify novel human papillomaviruses (HPV) and new DNA sequencing method based on real-time phyrophosphate are examples as new techniques.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALrachel_simoeseortrud_IOC_2015.pdfapplication/pdf761088https://www.arca.fiocruz.br/bitstream/icict/14438/1/rachel_simoeseortrud_IOC_2015.pdfe875708cca1075aa985854bfb3ee5ca1MD51LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14438/2/license.txt5a560609d32a3863062d77ff32785d58MD52TEXTrachel_simoeseortrud_IOC_2015.pdf.txtrachel_simoeseortrud_IOC_2015.pdf.txtExtracted texttext/plain29324https://www.arca.fiocruz.br/bitstream/icict/14438/3/rachel_simoeseortrud_IOC_2015.pdf.txt1ff1728cc0054c31e4139f9fc15ae8faMD53icict/144382022-06-24 13:10:59.686oai:www.arca.fiocruz.br:icict/14438Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:10:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets
title Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets
spellingShingle Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets
Simões, Rachel Siqueira de Queiroz
Papilomavírus
Vectores virais e não virais
Cromossomos
Terapia de genes
Papillomavirus
Viral and non-viral vector
Chromosomes
Gene therapy
title_short Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets
title_full Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets
title_fullStr Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets
title_full_unstemmed Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets
title_sort Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets
author Simões, Rachel Siqueira de Queiroz
author_facet Simões, Rachel Siqueira de Queiroz
Barth, Ortrud Monika
author_role author
author2 Barth, Ortrud Monika
author2_role author
dc.contributor.author.fl_str_mv Simões, Rachel Siqueira de Queiroz
Barth, Ortrud Monika
dc.subject.other.pt_BR.fl_str_mv Papilomavírus
Vectores virais e não virais
Cromossomos
Terapia de genes
topic Papilomavírus
Vectores virais e não virais
Cromossomos
Terapia de genes
Papillomavirus
Viral and non-viral vector
Chromosomes
Gene therapy
dc.subject.en.pt_BR.fl_str_mv Papillomavirus
Viral and non-viral vector
Chromosomes
Gene therapy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-06-02T13:05:57Z
2016-06-03T12:34:19Z
dc.date.available.fl_str_mv 2016-06-02T13:05:57Z
2016-06-03T12:34:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SIMÕES, Rachel Siqueira de Queiroz; BARTH, Ortrud Monika. Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets. International Journal of Biomedical Research, v.6, n.10, p.763-768, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14438
dc.identifier.issn.pt_BR.fl_str_mv 2455-0566
dc.identifier.doi.pt_BR.fl_str_mv 10.7439/ijbr
dc.identifier.eissn.pt_BR.fl_str_mv 0976-9633
identifier_str_mv SIMÕES, Rachel Siqueira de Queiroz; BARTH, Ortrud Monika. Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets. International Journal of Biomedical Research, v.6, n.10, p.763-768, 2015.
2455-0566
10.7439/ijbr
0976-9633
url https://www.arca.fiocruz.br/handle/icict/14438
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Scholar Science Journals
publisher.none.fl_str_mv Scholar Science Journals
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/14438/1/rachel_simoeseortrud_IOC_2015.pdf
https://www.arca.fiocruz.br/bitstream/icict/14438/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/14438/3/rachel_simoeseortrud_IOC_2015.pdf.txt
bitstream.checksum.fl_str_mv e875708cca1075aa985854bfb3ee5ca1
5a560609d32a3863062d77ff32785d58
1ff1728cc0054c31e4139f9fc15ae8fa
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009167283126272

Registros relacionados