Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018

Rezende, Izabela Maurıcio de; Sacchetto, Lıvia; Mello, Erica Munhoz de; Alves, Pedro Augusto; Iani, Felipe Campos de Melo; Adelino, Talita Emile Ribeiro; Duarte, Myrian Morato; Cury, Ana Luısa Furtado; Bernardes, Andre Felipe Leal; Santos, Tayrine Araujo; Pereira, Leonardo Soares; Dutra, Maria Rita Teixeira; Ramalho, Dario Brock; Thoisy, Benoit de; Kroon, Erna Geessien; Trindade, Giliane de Souza; Drumond, Betania Paiva

Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018

Detalhes bibliográficos
Autor(a) principal:	Rezende, Izabela Maurıcio de
Data de Publicação:	2018
Outros Autores:	Sacchetto, Lıvia, Mello, Erica Munhoz de, Alves, Pedro Augusto, Iani, Felipe Campos de Melo, Adelino, Talita Emile Ribeiro, Duarte, Myrian Morato, Cury, Ana Luısa Furtado, Bernardes, Andre Felipe Leal, Santos, Tayrine Araujo, Pereira, Leonardo Soares, Dutra, Maria Rita Teixeira, Ramalho, Dario Brock, Thoisy, Benoit de, Kroon, Erna Geessien, Trindade, Giliane de Souza, Drumond, Betania Paiva
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/27733
Resumo:	Universidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, Brazil

Metadados do item

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repository_id_str	2135
spelling	Rezende, Izabela Maurıcio deSacchetto, LıviaMello, Erica Munhoz deAlves, Pedro AugustoIani, Felipe Campos de MeloAdelino, Talita Emile RibeiroDuarte, Myrian MoratoCury, Ana Luısa FurtadoBernardes, Andre Felipe LealSantos, Tayrine AraujoPereira, Leonardo SoaresDutra, Maria Rita TeixeiraRamalho, Dario BrockThoisy, Benoit deKroon, Erna GeessienTrindade, Giliane de SouzaDrumond, Betania Paiva2018-07-31T13:52:18Z2018-07-31T13:52:18Z2018REZENDE, Izabela Maurıcio de et al. Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018. PLoS Negl Trop Dis., v. 12, n. 6, e0006538, 20181935-2727https://www.arca.fiocruz.br/handle/icict/2773310.1371/journal.pntd.0006538engPublic Library of Sciencefebre amarelaYellow feverPersistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, BrazilPrefeitura de Belo Horizonte. Centro de Controle de Zoonoses. Belo Horizonte, MG, BrazilFundaçao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Imunologia de Doenças Virais. Belo Horizonte, MG, BrazilFundaçao Ezequiel Dias. Serviço de Virologia e Riquetsioses. Belo Horizonte, MG, BrazilFundaçao Ezequiel Dias. Serviço de Virologia e Riquetsioses. Belo Horizonte, MG, BrazilFundaçao Ezequiel Dias. Serviço de Virologia e Riquetsioses. Belo Horizonte, MG, BrazilFundaçao Ezequiel Dias. Serviço de Virologia e Riquetsioses. Belo Horizonte, MG, BrazilFundaçao Ezequiel Dias. Serviço de Virologia e Riquetsioses. Belo Horizonte, MG, BrazilFundaçao Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, BrazilFundaçao Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, BrazilFundaçao Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, BrazilFundaçao Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, BrazilLaboratoire des Interaction Virus-Hotes. Institut Pasteur, Cayenne. French GuianaUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, BrazilBackground: Yellow fever (YF) is endemic in the Brazilian Amazon Basin, and sporadic outbreaks take place outside the endemic area in Brazil. Since 2016, YF epidemics have been occurring in Southeast Brazil, with more than 1,900 human cases and more than 1,600 epizooties of non-human primates (NHPs) reported until April 2018. Previous studies have demonstrated that Yellow fever virus (YFV) causing outbreaks in 2017 formed a monophyletic group. Methodology/Principal findings: Aiming to decipher the origin of the YFV responsible for the recent epidemics, we obtained nucleotide sequences of YFV detected in humans (n = 6) and NHPs (n = 10) from Minas Gerais state during 2017±2018. Next, we performed evolutionary analyses and discussed the results in the light of epidemiological records (official numbers of YFV cases at each Brazilian Federative unit, reported by the Brazilian Ministry of Health). Nucleotide sequences of YFV from Southeast Brazil from 2016 to 2018 were highly conserved and formed a monophyletic lineage (BR-YFV_2016/18) within the genotype South America I. Different clusters were observed within lineage BR-YFV_2016/18, one containing the majority of isolates (from humans and NHPs), indicating the sylvatic transmission of YFV. We also detected a cluster characterized by two synapomorphies (amino acid substitutions) that contained YFV only associated with NHP what should be further investigated. The topology of lineage BRYFV_2016/18 was congruent with epidemiological and temporal patterns of the on going epidemic. YFV isolates detected in 2016, in São Paulo state were located in the most basal position of the lineage, followed by the isolates from Minas Gerais and Espirito Santo obtained in 2017 and 2018. The most recent common ancestor of the lineage BRYFV_2016/18 dated to 2015 (95% credible intervals = 2014±2016), in a period that was coincident with the reemergence of YFV in the Midwest region of Brazil. Conclusions: The results demonstrated a single introduction of YFV in the Southeast region and the silent viral circulation before the onset of the outbreaks in 2016. Evolutionary analyses combined with epidemiological records supported the idea that BR-YFV_2016/18 was probably introduced from the Midwest into the Southeast region, possibly in São Paulo state. The persistence of YFV in the Southeast region, causing epidemics from 2016 to 2018, suggests that this region presents suitable ecological and climatic conditions for YFV maintenance during the epidemic and interepidemic seasons. This fact poses risks for the establishing of YF enzootic cycles and epidemics, outside the Amazon Basin in Brazil. YF surveillance and studies of viral dynamics deserve particular attention, especially in Midwest, Southeast and neighbor regions which are the main areas historically associated with YF outbreaks outside the Amazon Basin. YFV persistence in Southeast Brazil should be carefully considered in the context of public health, especially for public health decision-makers and researchers.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/27733/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIRR - Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018.pdfIRR - Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018.pdfapplication/pdf266093https://www.arca.fiocruz.br/bitstream/icict/27733/2/IRR%20-%20Persistence%20of%20Yellow%20fever%20virus%20outside%20the%20Amazon%20Basin%2c%20causing%20epidemics%20in%20Southeast%20Brazil%2c%20from%202016%20to%202018.pdfc6d02b9ec973bf408bf16f5f5a6e5417MD52TEXTIRR - 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dc.title.pt_BR.fl_str_mv	Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018
title	Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018
spellingShingle	Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018 Rezende, Izabela Maurıcio de febre amarela Yellow fever
title_short	Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018
title_full	Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018
title_fullStr	Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018
title_full_unstemmed	Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018
title_sort	Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018
author	Rezende, Izabela Maurıcio de
author_facet	Rezende, Izabela Maurıcio de Sacchetto, Lıvia Mello, Erica Munhoz de Alves, Pedro Augusto Iani, Felipe Campos de Melo Adelino, Talita Emile Ribeiro Duarte, Myrian Morato Cury, Ana Luısa Furtado Bernardes, Andre Felipe Leal Santos, Tayrine Araujo Pereira, Leonardo Soares Dutra, Maria Rita Teixeira Ramalho, Dario Brock Thoisy, Benoit de Kroon, Erna Geessien Trindade, Giliane de Souza Drumond, Betania Paiva
author_role	author
author2	Sacchetto, Lıvia Mello, Erica Munhoz de Alves, Pedro Augusto Iani, Felipe Campos de Melo Adelino, Talita Emile Ribeiro Duarte, Myrian Morato Cury, Ana Luısa Furtado Bernardes, Andre Felipe Leal Santos, Tayrine Araujo Pereira, Leonardo Soares Dutra, Maria Rita Teixeira Ramalho, Dario Brock Thoisy, Benoit de Kroon, Erna Geessien Trindade, Giliane de Souza Drumond, Betania Paiva
author2_role	author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Rezende, Izabela Maurıcio de Sacchetto, Lıvia Mello, Erica Munhoz de Alves, Pedro Augusto Iani, Felipe Campos de Melo Adelino, Talita Emile Ribeiro Duarte, Myrian Morato Cury, Ana Luısa Furtado Bernardes, Andre Felipe Leal Santos, Tayrine Araujo Pereira, Leonardo Soares Dutra, Maria Rita Teixeira Ramalho, Dario Brock Thoisy, Benoit de Kroon, Erna Geessien Trindade, Giliane de Souza Drumond, Betania Paiva
dc.subject.other.pt_BR.fl_str_mv	febre amarela
topic	febre amarela Yellow fever
dc.subject.en.pt_BR.fl_str_mv	Yellow fever
description	Universidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, Brazil
publishDate	2018
dc.date.accessioned.fl_str_mv	2018-07-31T13:52:18Z
dc.date.available.fl_str_mv	2018-07-31T13:52:18Z
dc.date.issued.fl_str_mv	2018
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	REZENDE, Izabela Maurıcio de et al. Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018. PLoS Negl Trop Dis., v. 12, n. 6, e0006538, 2018
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/27733
dc.identifier.issn.pt_BR.fl_str_mv	1935-2727
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pntd.0006538
identifier_str_mv	REZENDE, Izabela Maurıcio de et al. Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018. PLoS Negl Trop Dis., v. 12, n. 6, e0006538, 2018 1935-2727 10.1371/journal.pntd.0006538
url	https://www.arca.fiocruz.br/handle/icict/27733
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/27733/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/27733/2/IRR%20-%20Persistence%20of%20Yellow%20fever%20virus%20outside%20the%20Amazon%20Basin%2c%20causing%20epidemics%20in%20Southeast%20Brazil%2c%20from%202016%20to%202018.pdf https://www.arca.fiocruz.br/bitstream/icict/27733/3/IRR%20-%20Persistence%20of%20Yellow%20fever%20virus%20outside%20the%20Amazon%20Basin%2c%20causing%20epidemics%20in%20Southeast%20Brazil%2c%20from%202016%20to%202018.pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018

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