Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy

Detalhes bibliográficos
Autor(a) principal: Gusatti, Carolina Souza
Data de Publicação: 2015
Outros Autores: Costi, Cintia, Halon, Maria Laura, Grandi, Tarciana, Medeiros, Arlete Ferrari Rech, Silva, Cláudia Maria Dornelles, Gomes, Selma Andrade, Silva, Marcia Susana Nunes, Niel, Christian, Rossetti, Maria Lucia Rosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13525
Resumo: Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia. Programa de Pós-Graduação em Biologia Celular e Molecular.. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.
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spelling Gusatti, Carolina SouzaCosti, CintiaHalon, Maria LauraGrandi, TarcianaMedeiros, Arlete Ferrari RechSilva, Cláudia Maria DornellesGomes, Selma AndradeSilva, Marcia Susana NunesNiel, ChristianRossetti, Maria Lucia Rosa2016-04-05T12:18:07Z2016-04-05T12:18:07Z2015GUSATTI, Carolina Souza; et al. Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy. Plos One, v.10, n.8, e0135816, 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1352510.1371/journal.pone.0135816engPublic Library of ScienceVírus da Hepatite BChapecó, SCHepatitis B virusHepatitis B Virus Genotype DChapecó, SCItalian immigrationHepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande do Sul. Centro de Biotecnologia. Programa de Pós-Graduação em Biologia Celular e Molecular.. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Secretaria Municipal de Saúde. Setor de Hepatites Virais. Chapecó, SC, Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Luterana do Brasil. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde. Canoas, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia. Programa de Pós-Graduação em Biologia Celular e Molecular.. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil/ Universidade Luterana do Brasil. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde. Canoas, RS, Brasil.Hepatitis B virus genotype A1 (HBV/A1), of African origin, is the most prevalent genotype in Brazil, while HBV/F predominates in the other South American countries. However, HBV/D is the most common in the three states of southern Brazil, where ‘islands’ of elevated prevalence, as Chapecó and other cities, have been described. In this study, 202 HBV chronic carriers attending in 2013 the viral hepatitis ambulatory of Chapecó, were investigated. In comparison with previous studies performed in the same ambulatory, a rapid aging of the HBV infected population was observed (mean age of the newly diagnosed patients increasing from 29.9 ± 10.3 years in 1996 to 44.4 ± 13.3 years in 2013), probably due to a singular vaccination schedule at Chapecó that included not only children but also adolescents. Phylogenetic and BLAST analyses (S region) classified 91 HBV isolates into genotypes A (n = 3) and D (n = 88). The majority of HBV/D isolates were closely related to D3 sequences. To understand the reasons for the absence or near absence of genotypes A and F, and how HBV/D was introduced in the south of Brazil, HBV/D infected patients were inquired about their genealogical and geographical origins. Forty-three (52%) patients have their four grandparents of Italian origin, vs. seven (8%) who have their four grandparents of Brazilian origin. At all, 65 out of 83 (78%) patients had at least one grandparent originating from Italy. Taking into consideration the fact that Italy is one of the few countries where subgenotype D3 is predominant, the results strongly suggested that HBV/D was introduced in Brazil through Italian immigration which culminated between 1870 and 1920.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13525/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALselma_gomes_etal_IOC_2015.PDFselma_gomes_etal_IOC_2015.PDFapplication/pdf449862https://www.arca.fiocruz.br/bitstream/icict/13525/2/selma_gomes_etal_IOC_2015.PDF2871b1d8f6f8e85bebf58a1d474184ceMD52TEXTselma_gomes_etal_IOC_2015.PDF.txtselma_gomes_etal_IOC_2015.PDF.txtExtracted texttext/plain48665https://www.arca.fiocruz.br/bitstream/icict/13525/3/selma_gomes_etal_IOC_2015.PDF.txtc90696a239da7b10a652a8f13c1b0255MD53icict/135252018-04-02 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dc.title.pt_BR.fl_str_mv Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy
title Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy
spellingShingle Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy
Gusatti, Carolina Souza
Vírus da Hepatite B
Chapecó, SC
Hepatitis B virus
Hepatitis B Virus Genotype D
Chapecó, SC
Italian immigration
title_short Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy
title_full Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy
title_fullStr Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy
title_full_unstemmed Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy
title_sort Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy
author Gusatti, Carolina Souza
author_facet Gusatti, Carolina Souza
Costi, Cintia
Halon, Maria Laura
Grandi, Tarciana
Medeiros, Arlete Ferrari Rech
Silva, Cláudia Maria Dornelles
Gomes, Selma Andrade
Silva, Marcia Susana Nunes
Niel, Christian
Rossetti, Maria Lucia Rosa
author_role author
author2 Costi, Cintia
Halon, Maria Laura
Grandi, Tarciana
Medeiros, Arlete Ferrari Rech
Silva, Cláudia Maria Dornelles
Gomes, Selma Andrade
Silva, Marcia Susana Nunes
Niel, Christian
Rossetti, Maria Lucia Rosa
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gusatti, Carolina Souza
Costi, Cintia
Halon, Maria Laura
Grandi, Tarciana
Medeiros, Arlete Ferrari Rech
Silva, Cláudia Maria Dornelles
Gomes, Selma Andrade
Silva, Marcia Susana Nunes
Niel, Christian
Rossetti, Maria Lucia Rosa
dc.subject.other.pt_BR.fl_str_mv Vírus da Hepatite B
Chapecó, SC
topic Vírus da Hepatite B
Chapecó, SC
Hepatitis B virus
Hepatitis B Virus Genotype D
Chapecó, SC
Italian immigration
dc.subject.en.pt_BR.fl_str_mv Hepatitis B virus
Hepatitis B Virus Genotype D
Chapecó, SC
Italian immigration
description Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia. Programa de Pós-Graduação em Biologia Celular e Molecular.. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-05T12:18:07Z
dc.date.available.fl_str_mv 2016-04-05T12:18:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUSATTI, Carolina Souza; et al. Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy. Plos One, v.10, n.8, e0135816, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13525
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0135816
identifier_str_mv GUSATTI, Carolina Souza; et al. Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy. Plos One, v.10, n.8, e0135816, 2015.
1932-6203
10.1371/journal.pone.0135816
url https://www.arca.fiocruz.br/handle/icict/13525
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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