Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1371/journal.pone.0135816 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13525 |
Resumo: | Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia. Programa de Pós-Graduação em Biologia Celular e Molecular.. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil. |
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Gusatti, Carolina SouzaCosti, CintiaHalon, Maria LauraGrandi, TarcianaMedeiros, Arlete Ferrari RechSilva, Cláudia Maria DornellesGomes, Selma AndradeSilva, Marcia Susana NunesNiel, ChristianRossetti, Maria Lucia Rosa2016-04-05T12:18:07Z2016-04-05T12:18:07Z2015GUSATTI, Carolina Souza; et al. Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy. Plos One, v.10, n.8, e0135816, 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1352510.1371/journal.pone.0135816engPublic Library of ScienceVírus da Hepatite BChapecó, SCHepatitis B virusHepatitis B Virus Genotype DChapecó, SCItalian immigrationHepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande do Sul. Centro de Biotecnologia. Programa de Pós-Graduação em Biologia Celular e Molecular.. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Secretaria Municipal de Saúde. Setor de Hepatites Virais. Chapecó, SC, Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Luterana do Brasil. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde. Canoas, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia. Programa de Pós-Graduação em Biologia Celular e Molecular.. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil/ Universidade Luterana do Brasil. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde. Canoas, RS, Brasil.Hepatitis B virus genotype A1 (HBV/A1), of African origin, is the most prevalent genotype in Brazil, while HBV/F predominates in the other South American countries. However, HBV/D is the most common in the three states of southern Brazil, where ‘islands’ of elevated prevalence, as Chapecó and other cities, have been described. In this study, 202 HBV chronic carriers attending in 2013 the viral hepatitis ambulatory of Chapecó, were investigated. In comparison with previous studies performed in the same ambulatory, a rapid aging of the HBV infected population was observed (mean age of the newly diagnosed patients increasing from 29.9 ± 10.3 years in 1996 to 44.4 ± 13.3 years in 2013), probably due to a singular vaccination schedule at Chapecó that included not only children but also adolescents. Phylogenetic and BLAST analyses (S region) classified 91 HBV isolates into genotypes A (n = 3) and D (n = 88). The majority of HBV/D isolates were closely related to D3 sequences. To understand the reasons for the absence or near absence of genotypes A and F, and how HBV/D was introduced in the south of Brazil, HBV/D infected patients were inquired about their genealogical and geographical origins. Forty-three (52%) patients have their four grandparents of Italian origin, vs. seven (8%) who have their four grandparents of Brazilian origin. At all, 65 out of 83 (78%) patients had at least one grandparent originating from Italy. Taking into consideration the fact that Italy is one of the few countries where subgenotype D3 is predominant, the results strongly suggested that HBV/D was introduced in Brazil through Italian immigration which culminated between 1870 and 1920.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13525/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALselma_gomes_etal_IOC_2015.PDFselma_gomes_etal_IOC_2015.PDFapplication/pdf449862https://www.arca.fiocruz.br/bitstream/icict/13525/2/selma_gomes_etal_IOC_2015.PDF2871b1d8f6f8e85bebf58a1d474184ceMD52TEXTselma_gomes_etal_IOC_2015.PDF.txtselma_gomes_etal_IOC_2015.PDF.txtExtracted texttext/plain48665https://www.arca.fiocruz.br/bitstream/icict/13525/3/selma_gomes_etal_IOC_2015.PDF.txtc90696a239da7b10a652a8f13c1b0255MD53icict/135252018-04-02 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| dc.title.pt_BR.fl_str_mv |
Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy |
| title |
Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy |
| spellingShingle |
Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy Gusatti, Carolina Souza Vírus da Hepatite B Chapecó, SC Hepatitis B virus Hepatitis B Virus Genotype D Chapecó, SC Italian immigration |
| title_short |
Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy |
| title_full |
Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy |
| title_fullStr |
Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy |
| title_full_unstemmed |
Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy |
| title_sort |
Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy |
| author |
Gusatti, Carolina Souza |
| author_facet |
Gusatti, Carolina Souza Costi, Cintia Halon, Maria Laura Grandi, Tarciana Medeiros, Arlete Ferrari Rech Silva, Cláudia Maria Dornelles Gomes, Selma Andrade Silva, Marcia Susana Nunes Niel, Christian Rossetti, Maria Lucia Rosa |
| author_role |
author |
| author2 |
Costi, Cintia Halon, Maria Laura Grandi, Tarciana Medeiros, Arlete Ferrari Rech Silva, Cláudia Maria Dornelles Gomes, Selma Andrade Silva, Marcia Susana Nunes Niel, Christian Rossetti, Maria Lucia Rosa |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gusatti, Carolina Souza Costi, Cintia Halon, Maria Laura Grandi, Tarciana Medeiros, Arlete Ferrari Rech Silva, Cláudia Maria Dornelles Gomes, Selma Andrade Silva, Marcia Susana Nunes Niel, Christian Rossetti, Maria Lucia Rosa |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da Hepatite B Chapecó, SC |
| topic |
Vírus da Hepatite B Chapecó, SC Hepatitis B virus Hepatitis B Virus Genotype D Chapecó, SC Italian immigration |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis B virus Hepatitis B Virus Genotype D Chapecó, SC Italian immigration |
| description |
Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia. Programa de Pós-Graduação em Biologia Celular e Molecular.. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil. |
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2015 |
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GUSATTI, Carolina Souza; et al. Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy. Plos One, v.10, n.8, e0135816, 2015. |
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1932-6203 |
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10.1371/journal.pone.0135816 |
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GUSATTI, Carolina Souza; et al. Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy. Plos One, v.10, n.8, e0135816, 2015. 1932-6203 10.1371/journal.pone.0135816 |
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