A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections

Detalhes bibliográficos
Autor(a) principal: Bavia, Lorena
Data de Publicação: 2016
Outros Autores: Mosimann, Ana Luiza Pamplona, Aoki, Mateus Nóbrega, Santos, Claudia Nunes Duarte dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16151
Resumo: Fiocruz
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spelling Bavia, LorenaMosimann, Ana Luiza PamplonaAoki, Mateus NóbregaSantos, Claudia Nunes Duarte dos2016-10-07T18:07:41Z2016-10-07T18:07:41Z2016BAVIA, L., et al. A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections. Virol J., v. 13, n.84, p. 1-20, 2016.1743-422Xhttps://www.arca.fiocruz.br/handle/icict/1615110.1186/s12985-016-0541-3FiocruzFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.The family Flaviviridae comprises a wide variety of viruses that are distributed worldwide, some of which are associated with high rates of morbidity and mortality. There are neither vaccines nor antivirals for most flavivirus infections, reinforcing the importance of research on different aspects of the viral life cycle. During infection, cytoplasmic accumulation of RNA fragments mainly originating from the 3' UTRs, which have been designated subgenomic flavivirus RNAs (sfRNAs), has been detected. It has been shown that eukaryotic exoribonucleases are involved in viral sfRNA production. Additionally, viral and human small RNAs (sRNAs) have also been found in flavivirus-infected cells, especially microRNAs (miRNAs). miRNAs were first described in eukaryotic cells and in a mature and functional state present as single-stranded 18-24 nt RNA fragments. Their main function is the repression of translation through base pairing with cellular mRNAs, besides other functions, such as mRNA degradation. Canonical miRNA biogenesis involves Drosha and Dicer, however miRNA can also be generated by alternative pathways. In the case of flaviviruses, alternative pathways have been suggested. Both sfRNAs and miRNAs are involved in viral infection and host cell response modulation, representing interesting targets of antiviral strategies. In this review, we focus on the generation and function of viral sfRNAs, sRNAs and miRNAs in West Nile, dengue, Japanese encephalitis, Murray Valley encephalitis and yellow fever infections, as well as their roles in viral replication, translation and cell immune response evasion. We also give an overview regarding other flaviviruses and the generation of cellular miRNAs during infection.engLinfa WangA glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFlavivirusMicroRNAsSubgenomic flavivirus RNAsUntranslated regionViral replicationRegiões não TraduzidasReplicação Viralinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://www.arca.fiocruz.br/bitstream/icict/16151/1/license.txt0271fb68963c017aa933c7aff60379f4MD51ORIGINALA glance at subgenomic flavivirus RNAs.pdfA glance at subgenomic flavivirus RNAs.pdfapplication/pdf1116086https://www.arca.fiocruz.br/bitstream/icict/16151/2/A%20glance%20at%20subgenomic%20flavivirus%20RNAs.pdfad309753dad5211fbf1e8351e5c01fe9MD52TEXTA glance at subgenomic flavivirus RNAs.pdf.txtA glance 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dc.title.pt_BR.fl_str_mv A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections
title A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections
spellingShingle A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections
Bavia, Lorena
Flavivirus
MicroRNAs
Subgenomic flavivirus RNAs
Untranslated region
Viral replication
Regiões não Traduzidas
Replicação Viral
title_short A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections
title_full A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections
title_fullStr A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections
title_full_unstemmed A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections
title_sort A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections
author Bavia, Lorena
author_facet Bavia, Lorena
Mosimann, Ana Luiza Pamplona
Aoki, Mateus Nóbrega
Santos, Claudia Nunes Duarte dos
author_role author
author2 Mosimann, Ana Luiza Pamplona
Aoki, Mateus Nóbrega
Santos, Claudia Nunes Duarte dos
author2_role author
author
author
dc.contributor.author.fl_str_mv Bavia, Lorena
Mosimann, Ana Luiza Pamplona
Aoki, Mateus Nóbrega
Santos, Claudia Nunes Duarte dos
dc.subject.en.pt_BR.fl_str_mv Flavivirus
MicroRNAs
Subgenomic flavivirus RNAs
Untranslated region
Viral replication
topic Flavivirus
MicroRNAs
Subgenomic flavivirus RNAs
Untranslated region
Viral replication
Regiões não Traduzidas
Replicação Viral
dc.subject.decs.pt_BR.fl_str_mv Regiões não Traduzidas
Replicação Viral
description Fiocruz
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-10-07T18:07:41Z
dc.date.available.fl_str_mv 2016-10-07T18:07:41Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BAVIA, L., et al. A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections. Virol J., v. 13, n.84, p. 1-20, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16151
dc.identifier.issn.pt_BR.fl_str_mv 1743-422X
dc.identifier.doi.pt_BR.fl_str_mv 10.1186/s12985-016-0541-3
identifier_str_mv BAVIA, L., et al. A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections. Virol J., v. 13, n.84, p. 1-20, 2016.
1743-422X
10.1186/s12985-016-0541-3
url https://www.arca.fiocruz.br/handle/icict/16151
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Linfa Wang
publisher.none.fl_str_mv Linfa Wang
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16151/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/16151/3/A%20glance%20at%20subgenomic%20flavivirus%20RNAs.pdf.txt
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