Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil

Detalhes bibliográficos
Autor(a) principal: Carvalho-Sauer, Rita
Data de Publicação: 2021
Outros Autores: Flores-Ortiz, Renzo, Costa, Maria da Conceição N., Teixeira, Maria Gloria, Saavedra, Ramon, Niag, Marla, Paixão, Enny S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46918
Resumo: Bahia State Health Department. Núcleo Regional de Saúde Leste. Santo Antônio de Jesus, BA, Brazil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.
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spelling Carvalho-Sauer, RitaFlores-Ortiz, RenzoCosta, Maria da Conceição N.Teixeira, Maria GloriaSaavedra, RamonNiag, MarlaPaixão, Enny S.2021-04-26T19:55:53Z2021-04-26T19:55:53Z2023CARVALHO-SAUER, Rita et al. Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil. BMC Pregnancy and Childbirth, v. 23, n. 1, p. 1-10, May 2023.1471-2393https://www.arca.fiocruz.br/handle/icict/4691810.1186/s12884-023-05601-wengBioMed CentralFetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBahia State Health Department. Núcleo Regional de Saúde Leste. Santo Antônio de Jesus, BA, Brazil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Center for Data and Knowledge Integration for Health. Salvador, BA, Brazil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.Federal University of Recôncavo of Bahia. School of Medicine. Salvador, BA, Brazil.London School of Hygiene and Tropical Medicine. London, UK.Background: Fetal loss is one of the most serious adverse outcomes of pregnancy. Since the onset of the COVID-19 pandemic, Brazil has recorded an unprecedented number of hospitalizations of pregnant women due to acute respiratory distress (ARD), thereby, we aimed to assess the risk of fetal deaths associated to ARD during pregnancy in Bahia state, Brazil, in the context of the COVID-19 pandemic. Methods: This is an observational population-based retrospective cohort study, developed with women at or after 20 weeks of pregnancy, residents in Bahia, Brazil. Women who had acute respiratory distress (ARD) in pregnancy during the COVID-19 pandemic (Jan 2020 to Jun 2021) were considered 'exposed'. Women who did not have ARD in pregnancy, and whose pregnancy occurred before the onset of the COVID-19 pandemic (Jan 2019 to Dec 2019) were considered 'non-exposed'. The main outcome was fetal death. We linked administrative data (under mandatory registration) on live births, fetal deaths, and acute respiratory syndrome, using a probabilistic linkage method, and analyzed them with multivariable logistic regression models. Results: 200,979 pregnant women participated in this study, 765 exposed and 200,214 unexposed. We found four times higher chance of fetal death in women with ARD during pregnancy, of all etiologies (adjusted odds ratio [aOR] 4.06 confidence interval [CI] 95% 2.66; 6.21), and due to SARS-CoV-2 (aOR 4.45 CI 95% 2.41; 8.20). The risk of fetal death increased more when ARD in pregnancy was accompanied by vaginal delivery (aOR 7.06 CI 95% 4.21; 11.83), or admission to Intensive Care Unit (aOR 8.79 CI 95% 4.96; 15.58), or use of invasive mechanical ventilation (aOR 21.22 CI 95% 9.93; 45.36). Conclusion: Our findings can contribute to expanding the understanding of health professionals and managers about the harmful effects of SARS-CoV-2 on maternal-fetal health and alerts the need to prioritize pregnant women in preventive actions against SARS-CoV-2 and other respiratory viruses. It also suggests that pregnant women, infected with SARS-CoV-2, need to be monitored to prevent complications of ARD, including a careful assessment of the risks and benefits of early delivery to prevent fetal death.COVID-19PandemicFetal deathPregnancyPregnancy complicationsRespiratory distressSARS-CoV-2info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Rita_Carvalho‑Sauer_etal_IGM_2023.pdfve_Rita_Carvalho‑Sauer_etal_IGM_2023.pdfapplication/pdf1392293https://www.arca.fiocruz.br/bitstream/icict/46918/2/ve_Rita_Carvalho%e2%80%91Sauer_etal_IGM_2023.pdf018be5a08036fda3668262a18ee6143dMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/46918/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51icict/469182023-06-19 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dc.title.pt_BR.fl_str_mv Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil
title Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil
spellingShingle Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil
Carvalho-Sauer, Rita
COVID-19
Pandemic
Fetal death
Pregnancy
Pregnancy complications
Respiratory distress
SARS-CoV-2
title_short Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil
title_full Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil
title_fullStr Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil
title_full_unstemmed Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil
title_sort Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil
author Carvalho-Sauer, Rita
author_facet Carvalho-Sauer, Rita
Flores-Ortiz, Renzo
Costa, Maria da Conceição N.
Teixeira, Maria Gloria
Saavedra, Ramon
Niag, Marla
Paixão, Enny S.
author_role author
author2 Flores-Ortiz, Renzo
Costa, Maria da Conceição N.
Teixeira, Maria Gloria
Saavedra, Ramon
Niag, Marla
Paixão, Enny S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho-Sauer, Rita
Flores-Ortiz, Renzo
Costa, Maria da Conceição N.
Teixeira, Maria Gloria
Saavedra, Ramon
Niag, Marla
Paixão, Enny S.
dc.subject.en.pt_BR.fl_str_mv COVID-19
Pandemic
Fetal death
Pregnancy
Pregnancy complications
topic COVID-19
Pandemic
Fetal death
Pregnancy
Pregnancy complications
Respiratory distress
SARS-CoV-2
dc.subject.en.none.fl_str_mv Respiratory distress
SARS-CoV-2
description Bahia State Health Department. Núcleo Regional de Saúde Leste. Santo Antônio de Jesus, BA, Brazil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-26T19:55:53Z
dc.date.available.fl_str_mv 2021-04-26T19:55:53Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO-SAUER, Rita et al. Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil. BMC Pregnancy and Childbirth, v. 23, n. 1, p. 1-10, May 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46918
dc.identifier.issn.pt_BR.fl_str_mv 1471-2393
dc.identifier.doi.none.fl_str_mv 10.1186/s12884-023-05601-w
identifier_str_mv CARVALHO-SAUER, Rita et al. Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil. BMC Pregnancy and Childbirth, v. 23, n. 1, p. 1-10, May 2023.
1471-2393
10.1186/s12884-023-05601-w
url https://www.arca.fiocruz.br/handle/icict/46918
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/46918/2/ve_Rita_Carvalho%e2%80%91Sauer_etal_IGM_2023.pdf
https://www.arca.fiocruz.br/bitstream/icict/46918/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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