Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23399 |
Resumo: | Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA. |
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Palumbo, Philip J.Wilson, Ethan A.Piwowar-Manning, EstelleMcCauley, MarybethGamble, TheresaKumwenda, NewtonMakhema, JosephKumarasamy, NagalingeswaranChariyalertsak, SuwatHakim, James G.Hosseinipour, Mina C.Melo, Marineide G.Godbole, Sheela V.Pilotto, Jose H.Grinsztejn, BeatrizPanchia, RavindreChen, Ying Q.Cohen, Myron S.Eshleman, Susan H.Fogel, Jessica M.2017-11-28T10:42:19Z2017-11-28T10:42:19Z2017PALUMBO, Philip J. et al. Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052. PLoS ONE, v.12, n.5, e0177281, 9p, May 2017.1932-6203https://www.arca.fiocruz.br/handle/icict/2339910.1371/journal.pone.0177281engPublic Library of ScienceHIVTratamento antiretrovialInfecção experimentalresultados virológicosHIV diversityantiretroviral treatmentInfectionvirologic outcomesAssociation of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJohns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.Fred Hutchinson Cancer Research Center. Divisions of Vaccine and Infectious Disease. Seattle, Washington, USA..Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.Science Facilitation Department, FHI 360. Washington, DC, USA.Science Facilitation Department, FHI 360. Durham, NC, USA.College of Medicine. Johns Hopkins Project. Blantyre, Malawi.Botswana-Harvard AIDS Institute Partnership. Gaborone, Botswana.CART CRS, YRGCARE Medical Centre, VHS. Chennai, India.Chiang Mai University. Research Institute for Health Sciences. Chiang Mai, Thailand.Univ. of Zimbabwe. Dept. of Medicine. Harare, Zimbabwe.Univ. of North Carolina at Chapel Hill. Division of Infectious Diseases. Chapel Hill, NC, USA / Institute for Global Health and Infectious Diseases. UNC Project-Malawi. Lilongwe, Malawi.Hospital Nossa Senhora da Conceição. Serviço de Infectologia. Porto Alegre, RS, Brasil.National AIDS Research Institute. Pune, India.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular.. Rio de Janeiro, RJ. Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Univ. of the Witwatersrand. Perinatal HIV Research Unit. Soweto HPTN CRS, Soweto, South Africa.Fred Hutchinson Cancer Research Center. Divisions of Vaccine and Infectious Disease. Seattle, Washington, USA..Univ. of North Carolina at Chapel Hill. Dept. of Medicine. Chapel Hill, NC, USA.Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.Higher HIV diversity has been associated with virologic outcomes in children on antiretroviral treatment (ART). We examined the association of HIV diversity with virologic outcomes in adults from the HPTN 052 trial who initiated ART at CD4 cell counts of 350-550 cells/mm3. A high resolution melting (HRM) assay was used to analyze baseline (pre-treatment) HIV diversity in six regions in the HIV genome (two in gag, one in pol, and three in env) from 95 participants who failed ART. We analyzed the association of HIV diversity in each genomic region with baseline (pre-treatment) factors and three clinical outcomes: time to virologic suppression after ART initiation, time to ART failure, and emergence of HIV drug resistance at ART failure. After correcting for multiple comparisons, we did not find any association of baseline HIV diversity with demographic, laboratory, or clinical characteristics. For the 18 analyses performed for clinical outcomes evaluated, there was only one significant association: higher baseline HIV diversity in one of the three HIV env regions was associated with longer time to ART failure (p = 0.008). The HRM diversity assay may be useful in future studies exploring the relationship between HIV diversity and clinical outcomes in individuals with HIV infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23399/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjh_pilotto_etal_IOC_2017.pdfjh_pilotto_etal_IOC_2017.pdfapplication/pdf602055https://www.arca.fiocruz.br/bitstream/icict/23399/2/jh_pilotto_etal_IOC_2017.pdf5047cf331ddbb2cd027a1cf9bd76a0baMD52TEXTjh_pilotto_etal_IOC_2017.pdf.txtjh_pilotto_etal_IOC_2017.pdf.txtExtracted texttext/plain34542https://www.arca.fiocruz.br/bitstream/icict/23399/3/jh_pilotto_etal_IOC_2017.pdf.txtcdd0ffd537ed33ccf9a64d559aec3c18MD53icict/233992018-08-15 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| dc.title.pt_BR.fl_str_mv |
Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052 |
| title |
Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052 |
| spellingShingle |
Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052 Palumbo, Philip J. HIV Tratamento antiretrovial Infecção experimental resultados virológicos HIV diversity antiretroviral treatment Infection virologic outcomes |
| title_short |
Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052 |
| title_full |
Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052 |
| title_fullStr |
Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052 |
| title_full_unstemmed |
Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052 |
| title_sort |
Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052 |
| author |
Palumbo, Philip J. |
| author_facet |
Palumbo, Philip J. Wilson, Ethan A. Piwowar-Manning, Estelle McCauley, Marybeth Gamble, Theresa Kumwenda, Newton Makhema, Joseph Kumarasamy, Nagalingeswaran Chariyalertsak, Suwat Hakim, James G. Hosseinipour, Mina C. Melo, Marineide G. Godbole, Sheela V. Pilotto, Jose H. Grinsztejn, Beatriz Panchia, Ravindre Chen, Ying Q. Cohen, Myron S. Eshleman, Susan H. Fogel, Jessica M. |
| author_role |
author |
| author2 |
Wilson, Ethan A. Piwowar-Manning, Estelle McCauley, Marybeth Gamble, Theresa Kumwenda, Newton Makhema, Joseph Kumarasamy, Nagalingeswaran Chariyalertsak, Suwat Hakim, James G. Hosseinipour, Mina C. Melo, Marineide G. Godbole, Sheela V. Pilotto, Jose H. Grinsztejn, Beatriz Panchia, Ravindre Chen, Ying Q. Cohen, Myron S. Eshleman, Susan H. Fogel, Jessica M. |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Palumbo, Philip J. Wilson, Ethan A. Piwowar-Manning, Estelle McCauley, Marybeth Gamble, Theresa Kumwenda, Newton Makhema, Joseph Kumarasamy, Nagalingeswaran Chariyalertsak, Suwat Hakim, James G. Hosseinipour, Mina C. Melo, Marineide G. Godbole, Sheela V. Pilotto, Jose H. Grinsztejn, Beatriz Panchia, Ravindre Chen, Ying Q. Cohen, Myron S. Eshleman, Susan H. Fogel, Jessica M. |
| dc.subject.other.pt_BR.fl_str_mv |
HIV Tratamento antiretrovial Infecção experimental resultados virológicos |
| topic |
HIV Tratamento antiretrovial Infecção experimental resultados virológicos HIV diversity antiretroviral treatment Infection virologic outcomes |
| dc.subject.en.pt_BR.fl_str_mv |
HIV diversity antiretroviral treatment Infection virologic outcomes |
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Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA. |
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2017 |
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2017-11-28T10:42:19Z |
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2017-11-28T10:42:19Z |
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2017 |
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info:eu-repo/semantics/article |
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PALUMBO, Philip J. et al. Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052. PLoS ONE, v.12, n.5, e0177281, 9p, May 2017. |
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https://www.arca.fiocruz.br/handle/icict/23399 |
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1932-6203 |
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10.1371/journal.pone.0177281 |
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PALUMBO, Philip J. et al. Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052. PLoS ONE, v.12, n.5, e0177281, 9p, May 2017. 1932-6203 10.1371/journal.pone.0177281 |
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