Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052

Detalhes bibliográficos
Autor(a) principal: Palumbo, Philip J.
Data de Publicação: 2017
Outros Autores: Wilson, Ethan A., Piwowar-Manning, Estelle, McCauley, Marybeth, Gamble, Theresa, Kumwenda, Newton, Makhema, Joseph, Kumarasamy, Nagalingeswaran, Chariyalertsak, Suwat, Hakim, James G., Hosseinipour, Mina C., Melo, Marineide G., Godbole, Sheela V., Pilotto, Jose H., Grinsztejn, Beatriz, Panchia, Ravindre, Chen, Ying Q., Cohen, Myron S., Eshleman, Susan H., Fogel, Jessica M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23399
Resumo: Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.
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spelling Palumbo, Philip J.Wilson, Ethan A.Piwowar-Manning, EstelleMcCauley, MarybethGamble, TheresaKumwenda, NewtonMakhema, JosephKumarasamy, NagalingeswaranChariyalertsak, SuwatHakim, James G.Hosseinipour, Mina C.Melo, Marineide G.Godbole, Sheela V.Pilotto, Jose H.Grinsztejn, BeatrizPanchia, RavindreChen, Ying Q.Cohen, Myron S.Eshleman, Susan H.Fogel, Jessica M.2017-11-28T10:42:19Z2017-11-28T10:42:19Z2017PALUMBO, Philip J. et al. Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052. PLoS ONE, v.12, n.5, e0177281, 9p, May 2017.1932-6203https://www.arca.fiocruz.br/handle/icict/2339910.1371/journal.pone.0177281engPublic Library of ScienceHIVTratamento antiretrovialInfecção experimentalresultados virológicosHIV diversityantiretroviral treatmentInfectionvirologic outcomesAssociation of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJohns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.Fred Hutchinson Cancer Research Center. Divisions of Vaccine and Infectious Disease. Seattle, Washington, USA..Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.Science Facilitation Department, FHI 360. Washington, DC, USA.Science Facilitation Department, FHI 360. Durham, NC, USA.College of Medicine. Johns Hopkins Project. Blantyre, Malawi.Botswana-Harvard AIDS Institute Partnership. Gaborone, Botswana.CART CRS, YRGCARE Medical Centre, VHS. Chennai, India.Chiang Mai University. Research Institute for Health Sciences. Chiang Mai, Thailand.Univ. of Zimbabwe. Dept. of Medicine. Harare, Zimbabwe.Univ. of North Carolina at Chapel Hill. Division of Infectious Diseases. Chapel Hill, NC, USA / Institute for Global Health and Infectious Diseases. UNC Project-Malawi. Lilongwe, Malawi.Hospital Nossa Senhora da Conceição. Serviço de Infectologia. Porto Alegre, RS, Brasil.National AIDS Research Institute. Pune, India.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular.. Rio de Janeiro, RJ. Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Univ. of the Witwatersrand. Perinatal HIV Research Unit. Soweto HPTN CRS, Soweto, South Africa.Fred Hutchinson Cancer Research Center. Divisions of Vaccine and Infectious Disease. Seattle, Washington, USA..Univ. of North Carolina at Chapel Hill. Dept. of Medicine. Chapel Hill, NC, USA.Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.Higher HIV diversity has been associated with virologic outcomes in children on antiretroviral treatment (ART). We examined the association of HIV diversity with virologic outcomes in adults from the HPTN 052 trial who initiated ART at CD4 cell counts of 350-550 cells/mm3. A high resolution melting (HRM) assay was used to analyze baseline (pre-treatment) HIV diversity in six regions in the HIV genome (two in gag, one in pol, and three in env) from 95 participants who failed ART. We analyzed the association of HIV diversity in each genomic region with baseline (pre-treatment) factors and three clinical outcomes: time to virologic suppression after ART initiation, time to ART failure, and emergence of HIV drug resistance at ART failure. After correcting for multiple comparisons, we did not find any association of baseline HIV diversity with demographic, laboratory, or clinical characteristics. For the 18 analyses performed for clinical outcomes evaluated, there was only one significant association: higher baseline HIV diversity in one of the three HIV env regions was associated with longer time to ART failure (p = 0.008). The HRM diversity assay may be useful in future studies exploring the relationship between HIV diversity and clinical outcomes in individuals with HIV infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23399/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjh_pilotto_etal_IOC_2017.pdfjh_pilotto_etal_IOC_2017.pdfapplication/pdf602055https://www.arca.fiocruz.br/bitstream/icict/23399/2/jh_pilotto_etal_IOC_2017.pdf5047cf331ddbb2cd027a1cf9bd76a0baMD52TEXTjh_pilotto_etal_IOC_2017.pdf.txtjh_pilotto_etal_IOC_2017.pdf.txtExtracted texttext/plain34542https://www.arca.fiocruz.br/bitstream/icict/23399/3/jh_pilotto_etal_IOC_2017.pdf.txtcdd0ffd537ed33ccf9a64d559aec3c18MD53icict/233992018-08-15 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dc.title.pt_BR.fl_str_mv Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
title Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
spellingShingle Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
Palumbo, Philip J.
HIV
Tratamento antiretrovial
Infecção experimental
resultados virológicos
HIV diversity
antiretroviral treatment
Infection
virologic outcomes
title_short Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
title_full Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
title_fullStr Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
title_full_unstemmed Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
title_sort Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
author Palumbo, Philip J.
author_facet Palumbo, Philip J.
Wilson, Ethan A.
Piwowar-Manning, Estelle
McCauley, Marybeth
Gamble, Theresa
Kumwenda, Newton
Makhema, Joseph
Kumarasamy, Nagalingeswaran
Chariyalertsak, Suwat
Hakim, James G.
Hosseinipour, Mina C.
Melo, Marineide G.
Godbole, Sheela V.
Pilotto, Jose H.
Grinsztejn, Beatriz
Panchia, Ravindre
Chen, Ying Q.
Cohen, Myron S.
Eshleman, Susan H.
Fogel, Jessica M.
author_role author
author2 Wilson, Ethan A.
Piwowar-Manning, Estelle
McCauley, Marybeth
Gamble, Theresa
Kumwenda, Newton
Makhema, Joseph
Kumarasamy, Nagalingeswaran
Chariyalertsak, Suwat
Hakim, James G.
Hosseinipour, Mina C.
Melo, Marineide G.
Godbole, Sheela V.
Pilotto, Jose H.
Grinsztejn, Beatriz
Panchia, Ravindre
Chen, Ying Q.
Cohen, Myron S.
Eshleman, Susan H.
Fogel, Jessica M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Palumbo, Philip J.
Wilson, Ethan A.
Piwowar-Manning, Estelle
McCauley, Marybeth
Gamble, Theresa
Kumwenda, Newton
Makhema, Joseph
Kumarasamy, Nagalingeswaran
Chariyalertsak, Suwat
Hakim, James G.
Hosseinipour, Mina C.
Melo, Marineide G.
Godbole, Sheela V.
Pilotto, Jose H.
Grinsztejn, Beatriz
Panchia, Ravindre
Chen, Ying Q.
Cohen, Myron S.
Eshleman, Susan H.
Fogel, Jessica M.
dc.subject.other.pt_BR.fl_str_mv HIV
Tratamento antiretrovial
Infecção experimental
resultados virológicos
topic HIV
Tratamento antiretrovial
Infecção experimental
resultados virológicos
HIV diversity
antiretroviral treatment
Infection
virologic outcomes
dc.subject.en.pt_BR.fl_str_mv HIV diversity
antiretroviral treatment
Infection
virologic outcomes
description Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-11-28T10:42:19Z
dc.date.available.fl_str_mv 2017-11-28T10:42:19Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv PALUMBO, Philip J. et al. Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052. PLoS ONE, v.12, n.5, e0177281, 9p, May 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23399
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0177281
identifier_str_mv PALUMBO, Philip J. et al. Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052. PLoS ONE, v.12, n.5, e0177281, 9p, May 2017.
1932-6203
10.1371/journal.pone.0177281
url https://www.arca.fiocruz.br/handle/icict/23399
dc.language.iso.fl_str_mv eng
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