Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26029 |
Resumo: | Bezerra, Daniel Pereira. Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. a Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil b Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil c Physiology Department, Federal University of Sergipe, Sergipe, Brazil d Gonçalo Muniz Research Center, Oswaldo Cruz Foundation, Bahia, Brazil e Department of Mineralogy and Geotectonics, Institute of Geosciences, University of SãoPaulo-SP, Brazil |
id |
CRUZ_0958ea06c059ec34ad3c4f4774a19bbf |
---|---|
oai_identifier_str |
oai:www.arca.fiocruz.br:icict/26029 |
network_acronym_str |
CRUZ |
network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
repository_id_str |
2135 |
spelling |
Andrade, Tatianny de AraújoFreitas, Thiago Sampaio deAraújo, Francielly, OMenezes, Paula de PassosDória, Grace Anne AzevedoRabelo, Alessandra SilvaQuintans Júnior, Lucindo JoséSantos, Márcio Roberto VianaBezerra, Daniel PereiraSerafini, Mairim RussoMenezes, Irwin Rose Alencar deNunes, Paula SantosAraújo, Adriano Antunes de SouzaCosta, Maria do SocorroCampina, Fábia FerreiraSantos, Antonia Thassya Lucas dosSilva, Ana Raquel Pereira daCoutinho, Henrique Douglas Melo2018-04-23T13:48:34Z2018-04-23T13:48:34Z2017ANDRADE, T. A. et al. Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin. Biomedicine & Pharmacotherapy, v. 89, p. 201–207, 2017.0753-3322https://www.arca.fiocruz.br/handle/icict/2602910.1016/j.biopha.2017.01.158Bezerra, Daniel Pereira. Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. a Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil b Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil c Physiology Department, Federal University of Sergipe, Sergipe, Brazil d Gonçalo Muniz Research Center, Oswaldo Cruz Foundation, Bahia, Brazil e Department of Mineralogy and Geotectonics, Institute of Geosciences, University of SãoPaulo-SP, BrazilConselho Nacional de Desenvolvimento Científico e Tecnológico/CNPq/Brazil and Fundação de Amparo à Pesquisa do Estado de Sergipe/FAPITEC-SE.Múltipla – ver em NotasCyclodextrins (CDs) have been used as important pharmaceutical excipients for improve the physicochemical properties of the drugs of low solubility as the essential oil of Hyptis martiusii. This oil is important therapeutically, but the low solubility and bioavailability compromises your use. Therein, the aim of this study was to obtain and to characterize physico-chemically the samples obtained by physical mixture (PM), paste complexation (PC) and slurry complexation (SC) of the essential oil Hyptis martiusii (EOHM) in β-CD, and to compare the antibacterial and modulatory-antibiotic activity of products obtained and oil free. The physicochemical characterization was performed by differential scanning calorimetry (DSC), thermogravimetry/derivative thermogravimetry (TG/DTG), scanning electron microscopy (SEM), X-ray diffraction (XRD) and Karl Fischer titration. Additionally, the antibacterial tests were performed by microdilution technique. Thus, it was observed that the PM method showed low complexing capacity, unlike PC and SC in which it was observed the formation of inclusion complexes. In addition, the second stage of the TG/DTG curves showed that SC was the best method inclusion with mass loss of 6.9% over the PC that was 6.0%. The XRD results corroborate with the results above suggesting the formation of new solid phase and the SEM photomicrographs showed the porous surface of the samples PC and SC. The essential oil alone demonstrated an antibacterial and modulatory effect against the S. aureus and the Gram negative strain, respectively. However, the β-CD and the inclusion complex did not demonstrate any biological activity in the performed antibacterial assays.engElsevierÓleo essencialHyptis martiusiiComplexo de inclusãoAtividade antibiótica-modulatóriaAtividade antibacterianaEssential oilHyptis martiusiib-CDInclusion complexModulatory- antibiotic activityAntibacterial activityPhysico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26029/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAndrade TA Physico-chemical....pdfAndrade TA Physico-chemical....pdfapplication/pdf3585852https://www.arca.fiocruz.br/bitstream/icict/26029/2/Andrade%20TA%20Physico-chemical....pdf8a7e1bcbe17cb62a62c347459f8804baMD52TEXTAndrade TA Physico-chemical....pdf.txtAndrade TA Physico-chemical....pdf.txtExtracted texttext/plain34612https://www.arca.fiocruz.br/bitstream/icict/26029/3/Andrade%20TA%20Physico-chemical....pdf.txt0bb07ab2fa8214a2146577bc041aabf1MD53icict/260292023-03-15 14:33:54.675oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin |
title |
Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin |
spellingShingle |
Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin Andrade, Tatianny de Araújo Óleo essencial Hyptis martiusii Complexo de inclusão Atividade antibiótica-modulatória Atividade antibacteriana Essential oil Hyptis martiusii b-CD Inclusion complex Modulatory- antibiotic activity Antibacterial activity |
title_short |
Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin |
title_full |
Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin |
title_fullStr |
Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin |
title_full_unstemmed |
Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin |
title_sort |
Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin |
author |
Andrade, Tatianny de Araújo |
author_facet |
Andrade, Tatianny de Araújo Freitas, Thiago Sampaio de Araújo, Francielly, O Menezes, Paula de Passos Dória, Grace Anne Azevedo Rabelo, Alessandra Silva Quintans Júnior, Lucindo José Santos, Márcio Roberto Viana Bezerra, Daniel Pereira Serafini, Mairim Russo Menezes, Irwin Rose Alencar de Nunes, Paula Santos Araújo, Adriano Antunes de Souza Costa, Maria do Socorro Campina, Fábia Ferreira Santos, Antonia Thassya Lucas dos Silva, Ana Raquel Pereira da Coutinho, Henrique Douglas Melo |
author_role |
author |
author2 |
Freitas, Thiago Sampaio de Araújo, Francielly, O Menezes, Paula de Passos Dória, Grace Anne Azevedo Rabelo, Alessandra Silva Quintans Júnior, Lucindo José Santos, Márcio Roberto Viana Bezerra, Daniel Pereira Serafini, Mairim Russo Menezes, Irwin Rose Alencar de Nunes, Paula Santos Araújo, Adriano Antunes de Souza Costa, Maria do Socorro Campina, Fábia Ferreira Santos, Antonia Thassya Lucas dos Silva, Ana Raquel Pereira da Coutinho, Henrique Douglas Melo |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade, Tatianny de Araújo Freitas, Thiago Sampaio de Araújo, Francielly, O Menezes, Paula de Passos Dória, Grace Anne Azevedo Rabelo, Alessandra Silva Quintans Júnior, Lucindo José Santos, Márcio Roberto Viana Bezerra, Daniel Pereira Serafini, Mairim Russo Menezes, Irwin Rose Alencar de Nunes, Paula Santos Araújo, Adriano Antunes de Souza Costa, Maria do Socorro Campina, Fábia Ferreira Santos, Antonia Thassya Lucas dos Silva, Ana Raquel Pereira da Coutinho, Henrique Douglas Melo |
dc.subject.other.pt_BR.fl_str_mv |
Óleo essencial Hyptis martiusii Complexo de inclusão Atividade antibiótica-modulatória Atividade antibacteriana |
topic |
Óleo essencial Hyptis martiusii Complexo de inclusão Atividade antibiótica-modulatória Atividade antibacteriana Essential oil Hyptis martiusii b-CD Inclusion complex Modulatory- antibiotic activity Antibacterial activity |
dc.subject.en.pt_BR.fl_str_mv |
Essential oil Hyptis martiusii b-CD Inclusion complex Modulatory- antibiotic activity Antibacterial activity |
description |
Bezerra, Daniel Pereira. Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. a Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil b Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil c Physiology Department, Federal University of Sergipe, Sergipe, Brazil d Gonçalo Muniz Research Center, Oswaldo Cruz Foundation, Bahia, Brazil e Department of Mineralogy and Geotectonics, Institute of Geosciences, University of SãoPaulo-SP, Brazil |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2018-04-23T13:48:34Z |
dc.date.available.fl_str_mv |
2018-04-23T13:48:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ANDRADE, T. A. et al. Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin. Biomedicine & Pharmacotherapy, v. 89, p. 201–207, 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/26029 |
dc.identifier.issn.pt_BR.fl_str_mv |
0753-3322 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.biopha.2017.01.158 |
identifier_str_mv |
ANDRADE, T. A. et al. Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin. Biomedicine & Pharmacotherapy, v. 89, p. 201–207, 2017. 0753-3322 10.1016/j.biopha.2017.01.158 |
url |
https://www.arca.fiocruz.br/handle/icict/26029 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/26029/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/26029/2/Andrade%20TA%20Physico-chemical....pdf https://www.arca.fiocruz.br/bitstream/icict/26029/3/Andrade%20TA%20Physico-chemical....pdf.txt |
bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 8a7e1bcbe17cb62a62c347459f8804ba 0bb07ab2fa8214a2146577bc041aabf1 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1798324787678806016 |