Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin

Detalhes bibliográficos
Autor(a) principal: Andrade, Tatianny de Araújo
Data de Publicação: 2017
Outros Autores: Freitas, Thiago Sampaio de, Araújo, Francielly, O, Menezes, Paula de Passos, Dória, Grace Anne Azevedo, Rabelo, Alessandra Silva, Quintans Júnior, Lucindo José, Santos, Márcio Roberto Viana, Bezerra, Daniel Pereira, Serafini, Mairim Russo, Menezes, Irwin Rose Alencar de, Nunes, Paula Santos, Araújo, Adriano Antunes de Souza, Costa, Maria do Socorro, Campina, Fábia Ferreira, Santos, Antonia Thassya Lucas dos, Silva, Ana Raquel Pereira da, Coutinho, Henrique Douglas Melo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26029
Resumo: Bezerra, Daniel Pereira. Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. a Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil b Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil c Physiology Department, Federal University of Sergipe, Sergipe, Brazil d Gonçalo Muniz Research Center, Oswaldo Cruz Foundation, Bahia, Brazil e Department of Mineralogy and Geotectonics, Institute of Geosciences, University of SãoPaulo-SP, Brazil
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spelling Andrade, Tatianny de AraújoFreitas, Thiago Sampaio deAraújo, Francielly, OMenezes, Paula de PassosDória, Grace Anne AzevedoRabelo, Alessandra SilvaQuintans Júnior, Lucindo JoséSantos, Márcio Roberto VianaBezerra, Daniel PereiraSerafini, Mairim RussoMenezes, Irwin Rose Alencar deNunes, Paula SantosAraújo, Adriano Antunes de SouzaCosta, Maria do SocorroCampina, Fábia FerreiraSantos, Antonia Thassya Lucas dosSilva, Ana Raquel Pereira daCoutinho, Henrique Douglas Melo2018-04-23T13:48:34Z2018-04-23T13:48:34Z2017ANDRADE, T. A. et al. Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin. Biomedicine & Pharmacotherapy, v. 89, p. 201–207, 2017.0753-3322https://www.arca.fiocruz.br/handle/icict/2602910.1016/j.biopha.2017.01.158Bezerra, Daniel Pereira. Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. a Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil b Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil c Physiology Department, Federal University of Sergipe, Sergipe, Brazil d Gonçalo Muniz Research Center, Oswaldo Cruz Foundation, Bahia, Brazil e Department of Mineralogy and Geotectonics, Institute of Geosciences, University of SãoPaulo-SP, BrazilConselho Nacional de Desenvolvimento Científico e Tecnológico/CNPq/Brazil and Fundação de Amparo à Pesquisa do Estado de Sergipe/FAPITEC-SE.Múltipla – ver em NotasCyclodextrins (CDs) have been used as important pharmaceutical excipients for improve the physicochemical properties of the drugs of low solubility as the essential oil of Hyptis martiusii. This oil is important therapeutically, but the low solubility and bioavailability compromises your use. Therein, the aim of this study was to obtain and to characterize physico-chemically the samples obtained by physical mixture (PM), paste complexation (PC) and slurry complexation (SC) of the essential oil Hyptis martiusii (EOHM) in β-CD, and to compare the antibacterial and modulatory-antibiotic activity of products obtained and oil free. The physicochemical characterization was performed by differential scanning calorimetry (DSC), thermogravimetry/derivative thermogravimetry (TG/DTG), scanning electron microscopy (SEM), X-ray diffraction (XRD) and Karl Fischer titration. Additionally, the antibacterial tests were performed by microdilution technique. Thus, it was observed that the PM method showed low complexing capacity, unlike PC and SC in which it was observed the formation of inclusion complexes. In addition, the second stage of the TG/DTG curves showed that SC was the best method inclusion with mass loss of 6.9% over the PC that was 6.0%. The XRD results corroborate with the results above suggesting the formation of new solid phase and the SEM photomicrographs showed the porous surface of the samples PC and SC. The essential oil alone demonstrated an antibacterial and modulatory effect against the S. aureus and the Gram negative strain, respectively. However, the β-CD and the inclusion complex did not demonstrate any biological activity in the performed antibacterial assays.engElsevierÓleo essencialHyptis martiusiiComplexo de inclusãoAtividade antibiótica-modulatóriaAtividade antibacterianaEssential oilHyptis martiusiib-CDInclusion complexModulatory- antibiotic activityAntibacterial activityPhysico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26029/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAndrade TA Physico-chemical....pdfAndrade TA 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dc.title.pt_BR.fl_str_mv Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin
title Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin
spellingShingle Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin
Andrade, Tatianny de Araújo
Óleo essencial
Hyptis martiusii
Complexo de inclusão
Atividade antibiótica-modulatória
Atividade antibacteriana
Essential oil
Hyptis martiusii
b-CD
Inclusion complex
Modulatory- antibiotic activity
Antibacterial activity
title_short Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin
title_full Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin
title_fullStr Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin
title_full_unstemmed Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin
title_sort Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin
author Andrade, Tatianny de Araújo
author_facet Andrade, Tatianny de Araújo
Freitas, Thiago Sampaio de
Araújo, Francielly, O
Menezes, Paula de Passos
Dória, Grace Anne Azevedo
Rabelo, Alessandra Silva
Quintans Júnior, Lucindo José
Santos, Márcio Roberto Viana
Bezerra, Daniel Pereira
Serafini, Mairim Russo
Menezes, Irwin Rose Alencar de
Nunes, Paula Santos
Araújo, Adriano Antunes de Souza
Costa, Maria do Socorro
Campina, Fábia Ferreira
Santos, Antonia Thassya Lucas dos
Silva, Ana Raquel Pereira da
Coutinho, Henrique Douglas Melo
author_role author
author2 Freitas, Thiago Sampaio de
Araújo, Francielly, O
Menezes, Paula de Passos
Dória, Grace Anne Azevedo
Rabelo, Alessandra Silva
Quintans Júnior, Lucindo José
Santos, Márcio Roberto Viana
Bezerra, Daniel Pereira
Serafini, Mairim Russo
Menezes, Irwin Rose Alencar de
Nunes, Paula Santos
Araújo, Adriano Antunes de Souza
Costa, Maria do Socorro
Campina, Fábia Ferreira
Santos, Antonia Thassya Lucas dos
Silva, Ana Raquel Pereira da
Coutinho, Henrique Douglas Melo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Tatianny de Araújo
Freitas, Thiago Sampaio de
Araújo, Francielly, O
Menezes, Paula de Passos
Dória, Grace Anne Azevedo
Rabelo, Alessandra Silva
Quintans Júnior, Lucindo José
Santos, Márcio Roberto Viana
Bezerra, Daniel Pereira
Serafini, Mairim Russo
Menezes, Irwin Rose Alencar de
Nunes, Paula Santos
Araújo, Adriano Antunes de Souza
Costa, Maria do Socorro
Campina, Fábia Ferreira
Santos, Antonia Thassya Lucas dos
Silva, Ana Raquel Pereira da
Coutinho, Henrique Douglas Melo
dc.subject.other.pt_BR.fl_str_mv Óleo essencial
Hyptis martiusii
Complexo de inclusão
Atividade antibiótica-modulatória
Atividade antibacteriana
topic Óleo essencial
Hyptis martiusii
Complexo de inclusão
Atividade antibiótica-modulatória
Atividade antibacteriana
Essential oil
Hyptis martiusii
b-CD
Inclusion complex
Modulatory- antibiotic activity
Antibacterial activity
dc.subject.en.pt_BR.fl_str_mv Essential oil
Hyptis martiusii
b-CD
Inclusion complex
Modulatory- antibiotic activity
Antibacterial activity
description Bezerra, Daniel Pereira. Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. a Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil b Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil c Physiology Department, Federal University of Sergipe, Sergipe, Brazil d Gonçalo Muniz Research Center, Oswaldo Cruz Foundation, Bahia, Brazil e Department of Mineralogy and Geotectonics, Institute of Geosciences, University of SãoPaulo-SP, Brazil
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-04-23T13:48:34Z
dc.date.available.fl_str_mv 2018-04-23T13:48:34Z
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dc.identifier.citation.fl_str_mv ANDRADE, T. A. et al. Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin. Biomedicine & Pharmacotherapy, v. 89, p. 201–207, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26029
dc.identifier.issn.pt_BR.fl_str_mv 0753-3322
dc.identifier.doi.none.fl_str_mv 10.1016/j.biopha.2017.01.158
identifier_str_mv ANDRADE, T. A. et al. Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin. Biomedicine & Pharmacotherapy, v. 89, p. 201–207, 2017.
0753-3322
10.1016/j.biopha.2017.01.158
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