Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45669 |
Resumo: | 1. Funder: Fundação Oswaldo Cruz, Brazil a. Award number: Intramural Research Program b. Recipient: Bruno B. Andrade 2. Funder: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil a. Award number: senior fellowship b. Recipient: Bruno B. Andrade 3. Funder: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil a. Award number: fellowship (finance code 001) b. Recipient: Kiyoshi F. Fukutani 4. Funder: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior a. Award number: PhD fellowship b. Recipient: Rodrigo C. Menezes 5. Funder: Fundação de Amparo à Pesquisa do Estado da Bahia. |
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Menezes, Rodrigo C.Ferreira, Isabella B. B.Carmo, Thomas A.Telles, Gabriel P.Pugas, Paula L. D.Otero, Matheus L.Arriaga Gutiérrez, María BelenFukutani, Kiyoshi FerreiraNeto, Licurgo P.Agareno, SydneyFilgueiras Filho, Nivaldo M.Akrami, Kevan M.Andrade, Bruno de Bezerril2021-01-13T18:01:08Z2021-01-13T18:01:08Z2020MENEZES, Rodrigo C. et al. Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients. PloS One, p. 1-10, 2020.1932-6203https://www.arca.fiocruz.br/handle/icict/4566910.1371/journal.pone.02407931. Funder: Fundação Oswaldo Cruz, Brazil a. Award number: Intramural Research Program b. Recipient: Bruno B. Andrade 2. Funder: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil a. Award number: senior fellowship b. Recipient: Bruno B. Andrade 3. Funder: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil a. Award number: fellowship (finance code 001) b. Recipient: Kiyoshi F. Fukutani 4. Funder: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior a. Award number: PhD fellowship b. Recipient: Rodrigo C. Menezes 5. Funder: Fundação de Amparo à Pesquisa do Estado da Bahia.Hospital de Cidade. Núcleo de Pesquisa, Ensino e Comunicação. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade do Estado da Bahia. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Hospital de Cidade. Intensive Care Unit. Salvador, BA, Brazil.Hospital de Cidade. Núcleo de Pesquisa, Ensino e Comunicação. Salvador, BA, Brasil / Universidade do Estado da Bahia. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / University of California. Division of Infectious Diseases and Pulmonary Critical Care and Sleep Medicine. Department of Medicine. San Diego, CA, USA.Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.This study aimed to assess the performance of a commonly used ICU severity score (SAPS3) and determine whether an alternative scoring system may be more accurate across all age strata. Methods Retrospective cohort study in a general ICU in Brazil. A secondary analysis was performed with clinical and epidemiological data, present in the first 24 hours of unit admission. Then, a binary logistic regression, followed by cross-validation, was made to develop a novel prognostic tool. ICU mortality was the primary outcome evaluated. Results A total of 3042 patients were included over the study period between August 2015 and July 2018 with a median age of 67 ± 18.4 years. SAPS3 performed fairly in prediction of ICU mortality, particularly in the 80 years or older subset. Multivariable regression identified variables independently associated with mortality that were used to develop the Age Calibrated ICU Score (ACIS) tool that performed similarly to SAPS3 across age categories, being slightly superior in the very elderly population (AUC 0.80 vs 0.72).Conclusions The ACIS offers a robust and simple tool to predict ICU mortality, particularly in an increasingly elderly critical care population.engPublic Library of SciencePrognósticoUnidades de Terapia IntensivaSAPS3BrasilMortalidadePopulação idosaPrognosticIntensive Care UnitsSAPS3BrazilMortalityCare populationAre prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/45669/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALMenezes_Rodrigo_etal_IGM_2020.pdfMenezes_Rodrigo_etal_IGM_2020.pdfapplication/pdf1268132https://www.arca.fiocruz.br/bitstream/icict/45669/2/Menezes_Rodrigo_etal_IGM_2020.pdf9720585e8d8f3bdd327d13d5a6ed5645MD52TEXTMenezes_Rodrigo_etal_IGM_2020.pdf.txtMenezes_Rodrigo_etal_IGM_2020.pdf.txtExtracted texttext/plain31481https://www.arca.fiocruz.br/bitstream/icict/45669/3/Menezes_Rodrigo_etal_IGM_2020.pdf.txta20e3dd5c94d57147fe0fd00fccb9c17MD53icict/456692023-03-15 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| dc.title.pt_BR.fl_str_mv |
Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients |
| title |
Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients |
| spellingShingle |
Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients Menezes, Rodrigo C. Prognóstico Unidades de Terapia Intensiva SAPS3 Brasil Mortalidade População idosa Prognostic Intensive Care Units SAPS3 Brazil Mortality Care population |
| title_short |
Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients |
| title_full |
Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients |
| title_fullStr |
Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients |
| title_full_unstemmed |
Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients |
| title_sort |
Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients |
| author |
Menezes, Rodrigo C. |
| author_facet |
Menezes, Rodrigo C. Ferreira, Isabella B. B. Carmo, Thomas A. Telles, Gabriel P. Pugas, Paula L. D. Otero, Matheus L. Arriaga Gutiérrez, María Belen Fukutani, Kiyoshi Ferreira Neto, Licurgo P. Agareno, Sydney Filgueiras Filho, Nivaldo M. Akrami, Kevan M. Andrade, Bruno de Bezerril |
| author_role |
author |
| author2 |
Ferreira, Isabella B. B. Carmo, Thomas A. Telles, Gabriel P. Pugas, Paula L. D. Otero, Matheus L. Arriaga Gutiérrez, María Belen Fukutani, Kiyoshi Ferreira Neto, Licurgo P. Agareno, Sydney Filgueiras Filho, Nivaldo M. Akrami, Kevan M. Andrade, Bruno de Bezerril |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Menezes, Rodrigo C. Ferreira, Isabella B. B. Carmo, Thomas A. Telles, Gabriel P. Pugas, Paula L. D. Otero, Matheus L. Arriaga Gutiérrez, María Belen Fukutani, Kiyoshi Ferreira Neto, Licurgo P. Agareno, Sydney Filgueiras Filho, Nivaldo M. Akrami, Kevan M. Andrade, Bruno de Bezerril |
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Prognóstico Unidades de Terapia Intensiva SAPS3 Brasil Mortalidade População idosa |
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Prognóstico Unidades de Terapia Intensiva SAPS3 Brasil Mortalidade População idosa Prognostic Intensive Care Units SAPS3 Brazil Mortality Care population |
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Prognostic Intensive Care Units SAPS3 Brazil Mortality Care population |
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1. Funder: Fundação Oswaldo Cruz, Brazil a. Award number: Intramural Research Program b. Recipient: Bruno B. Andrade 2. Funder: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil a. Award number: senior fellowship b. Recipient: Bruno B. Andrade 3. Funder: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil a. Award number: fellowship (finance code 001) b. Recipient: Kiyoshi F. Fukutani 4. Funder: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior a. Award number: PhD fellowship b. Recipient: Rodrigo C. Menezes 5. Funder: Fundação de Amparo à Pesquisa do Estado da Bahia. |
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2020 |
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2020 |
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2021-01-13T18:01:08Z |
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MENEZES, Rodrigo C. et al. Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients. PloS One, p. 1-10, 2020. |
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10.1371/journal.pone.0240793 |
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MENEZES, Rodrigo C. et al. Are prognostic tools losing accuracy? Development and performance of a novel age-calibrated severity scoring system for critically ill patients. PloS One, p. 1-10, 2020. 1932-6203 10.1371/journal.pone.0240793 |
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