A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum

Detalhes bibliográficos
Autor(a) principal: Bastos, Marcele F.
Data de Publicação: 2019
Outros Autores: Albrecht, Letusa, Gomes, Angélica M., Lopes, Stefanie C. P., Vicente, Cristina P., Almeida, Rodrigo P. M. de, Cassiano, Gustavo C., Fonseca, Roberto J. C., Werneck, Claudio C., Pavão, Mauro S. G., Costa, Fabio T. M.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34045
Resumo: Universidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais. Campinas, SP, Brasil.
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spelling Bastos, Marcele F.Albrecht, LetusaGomes, Angélica M.Lopes, Stefanie C. P.Vicente, Cristina P.Almeida, Rodrigo P. M. deCassiano, Gustavo C.Fonseca, Roberto J. C.Werneck, Claudio C.Pavão, Mauro S. G.Costa, Fabio T. M.2019-07-12T19:40:48Z2019-07-12T19:40:48Z2019BASTOS, Marcele F. et al. A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-4, 2019.1678-8060https://www.arca.fiocruz.br/handle/icict/3404510.1590/0074-027601900881678-8060porFundação Oswaldo Cruz. Instituto Oswaldo CruzA new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Cleveland Clinic Lerner Research Institute. Department of Biomedical Engineering. Cleveland, OH, USA.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.Universidade Estadual de Campinas. Departamento de Biologia Estrutural e Funcional. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais. Campinas, SP, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Hospital Clementino Fraga Filho. Laboratório de Tecido Conjuntivo. Rio de Janeiro, RJ, Brasil.Universidade Estadual de Campinas. Departamento de Bioquímica e Biologia Tecidual. Campinas, SP, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo Meis. Programa de Glicobiologia. Rio de Janeiro, RJ, Brasil.Universidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais. Campinas, SP, Brasil.Despite treatment with effective antimalarial drugs, the mortality rate is still high in severe cases of the disease, highlighting the need to find adjunct therapies that can inhibit the adhesion of Plasmodium falciparum-infected erythrocytes (Pf-iEs). In this context, we evaluated a new heparan sulfate (HS) from Nodipecten nodosus for antimalarial activity and inhibition of P. falciparum cytoadhesion and rosetting. Parasite inhibition was measured by SYBR green using a cytometer. HS was assessed in rosetting and cytoadhesion assays under static and flow conditions using Chinese hamster ovary (CHO) and human lymphatic endothelial cell (HLEC) cells expressing intercellular adhesion molecule-1 (ICAM1) and chondroitin sulfate A (CSA), respectively. As findings, hast this HS inhibited merozoite invasion similar to heparin. Moreover, mollusk HS decreased cytoadherence of P. falciparum to CSA and ICAM-1 on the surface of endothelial cells under static and flow conditions. In addition, this glycan efficiently disrupted rosettes.GlycosaminoglycansMalariaCell Adhesion MoleculesAntimalarialsChemotherapy AdjuvantGlicosaminoglicanosMoléculas de Adhesión CelularQuimioterapia AdyuvanteGlicosaminoglicanosMaláriaMoléculas de Adesão CelularAntimaláricosPlasmodium falciparumQuimioterapia Adjuvanteinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/34045/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINAL1678-8060-mioc.pdf1678-8060-mioc.pdfapplication/pdf520671https://www.arca.fiocruz.br/bitstream/icict/34045/2/1678-8060-mioc.pdf678320acb1c80df35766372da3fa46c9MD52TEXT1678-8060-mioc.pdf.txt1678-8060-mioc.pdf.txtExtracted texttext/plain21822https://www.arca.fiocruz.br/bitstream/icict/34045/3/1678-8060-mioc.pdf.txt5468d4cf0e48aa057fa2a743e5a31287MD53icict/340452019-12-16 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dc.title.pt_BR.fl_str_mv A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
title A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
spellingShingle A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
Bastos, Marcele F.
Glycosaminoglycans
Malaria
Cell Adhesion Molecules
Antimalarials
Chemotherapy Adjuvant
Glicosaminoglicanos
Moléculas de Adhesión Celular
Quimioterapia Adyuvante
Glicosaminoglicanos
Malária
Moléculas de Adesão Celular
Antimaláricos
Plasmodium falciparum
Quimioterapia Adjuvante
title_short A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
title_full A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
title_fullStr A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
title_full_unstemmed A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
title_sort A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
author Bastos, Marcele F.
author_facet Bastos, Marcele F.
Albrecht, Letusa
Gomes, Angélica M.
Lopes, Stefanie C. P.
Vicente, Cristina P.
Almeida, Rodrigo P. M. de
Cassiano, Gustavo C.
Fonseca, Roberto J. C.
Werneck, Claudio C.
Pavão, Mauro S. G.
Costa, Fabio T. M.
author_role author
author2 Albrecht, Letusa
Gomes, Angélica M.
Lopes, Stefanie C. P.
Vicente, Cristina P.
Almeida, Rodrigo P. M. de
Cassiano, Gustavo C.
Fonseca, Roberto J. C.
Werneck, Claudio C.
Pavão, Mauro S. G.
Costa, Fabio T. M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bastos, Marcele F.
Albrecht, Letusa
Gomes, Angélica M.
Lopes, Stefanie C. P.
Vicente, Cristina P.
Almeida, Rodrigo P. M. de
Cassiano, Gustavo C.
Fonseca, Roberto J. C.
Werneck, Claudio C.
Pavão, Mauro S. G.
Costa, Fabio T. M.
dc.subject.en.pt_BR.fl_str_mv Glycosaminoglycans
Malaria
Cell Adhesion Molecules
Antimalarials
Chemotherapy Adjuvant
topic Glycosaminoglycans
Malaria
Cell Adhesion Molecules
Antimalarials
Chemotherapy Adjuvant
Glicosaminoglicanos
Moléculas de Adhesión Celular
Quimioterapia Adyuvante
Glicosaminoglicanos
Malária
Moléculas de Adesão Celular
Antimaláricos
Plasmodium falciparum
Quimioterapia Adjuvante
dc.subject.es.pt_BR.fl_str_mv Glicosaminoglicanos
Moléculas de Adhesión Celular
Quimioterapia Adyuvante
dc.subject.decs.pt_BR.fl_str_mv Glicosaminoglicanos
Malária
Moléculas de Adesão Celular
Antimaláricos
Plasmodium falciparum
Quimioterapia Adjuvante
description Universidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais. Campinas, SP, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-07-12T19:40:48Z
dc.date.available.fl_str_mv 2019-07-12T19:40:48Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BASTOS, Marcele F. et al. A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-4, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34045
dc.identifier.issn.pt_BR.fl_str_mv 1678-8060
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760190088
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv BASTOS, Marcele F. et al. A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-4, 2019.
1678-8060
10.1590/0074-02760190088
url https://www.arca.fiocruz.br/handle/icict/34045
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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