Update on the Phylodynamics of SADS-CoV

Detalhes bibliográficos
Autor(a) principal: Scarpa, Fabio
Data de Publicação: 2021
Outros Autores: Sanna, Daria, Azzena, Ilenia, Cossu, Piero, Giovanetti, Marta, Benvenuto, Domenico, Coradduzza, Elisabetta, Alexiev, Ivailo, Casu, Marco, Fiori, Pier Luigi, Ciccozzi, Massimo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.3390/ life11080820
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51443
Resumo: Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy.
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spelling Scarpa, FabioSanna, DariaAzzena, IleniaCossu, PieroGiovanetti, MartaBenvenuto, DomenicoCoradduzza, ElisabettaAlexiev, IvailoCasu, MarcoFiori, Pier LuigiCiccozzi, Massimo2022-02-23T20:17:35Z2022-02-23T20:17:35Z2021SCARPA, Fabio et al. Update on the Phylodynamics of SADS-CoV. Life, v. 11, 820, p. 1 - 11, Aug. 2021.2075-1729https://www.arca.fiocruz.br/handle/icict/5144310.3390/ life11080820engMDPICoronavírusEpidemiologiaDiversidade genéticaFilodinâmicaAlfacoronavírusPhylodynamicsGenetic diversityCoronavirusEpidemiologyAlphacoronavirusUpdate on the Phylodynamics of SADS-CoVinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy.Department of Biomedical Sciences, University of Sassari. 07100 Sassari, Italy.Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy / Department of Biomedical Sciences, University of Sassari. 07100 Sassari, Italy.Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome. 00128 Rome, Italy.Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy,National Reference Laboratory of HIV, National Center of Infectious and Parasitic Diseases. 1504 Sofia, Bulgaria.Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy.Department of Biomedical Sciences, University of Sassari. 07100 Sassari, Italy.Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome. 00128 Rome, Italy.Coronaviruses are known to be harmful and heterogeneous viruses, able to infect a large number of hosts. Among them, SADS-CoV (Swine Acute Diarrhea Syndrome Coronavirus), also known as PEAV (Porcine Enteric Alphacoronavirus), or SeA-CoV (Swine Enteric Alphacoronavirus), is the most recent Alphacoronavirus discovered, and caused several outbreaks reported in Chinese swine herds between late 2016 and 2019. We performed an upgraded phylodinamic reconstruction of SADS-CoV based on all whole genomes available on 21 June 2021. Results showed a very close relationship between SADS-CoV and HKU2-like CoV, which may represent the evolutionary intermediate step towards the present SADS-CoV. The direct progenitor of SADS-CoV is so far unknown and, although it is well known that horseshoe bats are reservoirs for Rhinolophus bat coronavirus HKU2-like (HKU2-like CoVs), the transmission path from bats to pigs is still unclear. The discrepancies in the phylogenetic position of rodent CoV, when different molecular markers were considered, corroborate the recombination hypothesis, suggesting that wild rats, which are frequent in farms, may have played a key role. The failure of the attempt at molecular dating, due to the lack of a clock signal, also corroborates the occurrence of a recombination event hypothesis. Zoonotic infections originating in wildlife can easily become a significant threat for human health. In such a context, due to the high recombination and cross-species capabilities of Coronavirus, SADS-CoV represents a possible high-risk pathogen for humans which needs a constant molecular monitoring.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51443/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFabioScarpa_MartaGiovnetti_etal-IOC_2021.pdfFabioScarpa_MartaGiovnetti_etal-IOC_2021.pdfapplication/pdf2738409https://www.arca.fiocruz.br/bitstream/icict/51443/2/FabioScarpa_MartaGiovnetti_etal-IOC_2021.pdf1fedc70287e0e5dd9b8ddebd27815a9dMD52icict/514432023-09-05 10:15:33.283oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:15:33Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.pt_BR.fl_str_mv Update on the Phylodynamics of SADS-CoV
title Update on the Phylodynamics of SADS-CoV
spellingShingle Update on the Phylodynamics of SADS-CoV
Scarpa, Fabio
Coronavírus
Epidemiologia
Diversidade genética
Filodinâmica
Alfacoronavírus
Phylodynamics
Genetic diversity
Coronavirus
Epidemiology
Alphacoronavirus
title_short Update on the Phylodynamics of SADS-CoV
title_full Update on the Phylodynamics of SADS-CoV
title_fullStr Update on the Phylodynamics of SADS-CoV
title_full_unstemmed Update on the Phylodynamics of SADS-CoV
title_sort Update on the Phylodynamics of SADS-CoV
author Scarpa, Fabio
author_facet Scarpa, Fabio
Sanna, Daria
Azzena, Ilenia
Cossu, Piero
Giovanetti, Marta
Benvenuto, Domenico
Coradduzza, Elisabetta
Alexiev, Ivailo
Casu, Marco
Fiori, Pier Luigi
Ciccozzi, Massimo
author_role author
author2 Sanna, Daria
Azzena, Ilenia
Cossu, Piero
Giovanetti, Marta
Benvenuto, Domenico
Coradduzza, Elisabetta
Alexiev, Ivailo
Casu, Marco
Fiori, Pier Luigi
Ciccozzi, Massimo
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Scarpa, Fabio
Sanna, Daria
Azzena, Ilenia
Cossu, Piero
Giovanetti, Marta
Benvenuto, Domenico
Coradduzza, Elisabetta
Alexiev, Ivailo
Casu, Marco
Fiori, Pier Luigi
Ciccozzi, Massimo
dc.subject.other.pt_BR.fl_str_mv Coronavírus
Epidemiologia
Diversidade genética
Filodinâmica
Alfacoronavírus
topic Coronavírus
Epidemiologia
Diversidade genética
Filodinâmica
Alfacoronavírus
Phylodynamics
Genetic diversity
Coronavirus
Epidemiology
Alphacoronavirus
dc.subject.en.pt_BR.fl_str_mv Phylodynamics
Genetic diversity
Coronavirus
Epidemiology
Alphacoronavirus
description Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-23T20:17:35Z
dc.date.available.fl_str_mv 2022-02-23T20:17:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCARPA, Fabio et al. Update on the Phylodynamics of SADS-CoV. Life, v. 11, 820, p. 1 - 11, Aug. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51443
dc.identifier.issn.pt_BR.fl_str_mv 2075-1729
dc.identifier.doi.none.fl_str_mv 10.3390/ life11080820
identifier_str_mv SCARPA, Fabio et al. Update on the Phylodynamics of SADS-CoV. Life, v. 11, 820, p. 1 - 11, Aug. 2021.
2075-1729
10.3390/ life11080820
url https://www.arca.fiocruz.br/handle/icict/51443
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51443/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51443/2/FabioScarpa_MartaGiovnetti_etal-IOC_2021.pdf
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