Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil

Detalhes bibliográficos
Autor(a) principal: Fontoura, Pablo S.
Data de Publicação: 2021
Outros Autores: Silva, Marcos F., Costa, Andreson S. da, Ribeiro, Francismar S., Ferreira, Marcílio S., Ladeia-Andrade, Simone, Tonini, Juliana, Rodrigues, Priscila T., Castro, Marcia C., Ferreira, Marcelo U.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48988
Resumo: Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.
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spelling Fontoura, Pablo S.Silva, Marcos F.Costa, Andreson S. daRibeiro, Francismar S.Ferreira, Marcílio S.Ladeia-Andrade, SimoneTonini, JulianaRodrigues, Priscila T.Castro, Marcia C.Ferreira, Marcelo U.2021-09-05T14:39:33Z2021-09-05T14:39:33Z2021FONTOURA, Pablo S. et al. Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil. Parasite & Vectors, v. 14, n. 445, 11 p, 2021.1756-3305https://www.arca.fiocruz.br/handle/icict/4898810.1186/s13071-021-04964-3engBMCMaláriaAnophelesLarvicidas biológicosPisciculturaAmazonasMalariaAnophelesBiological larvicidesFish farmingAmazonMonthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade Federal do Acre. Centro Multidisciplinar. Cruzeiro do Sul, AC, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Department of Global Health and Population, Harvard T. H. Chan School of Public Health. Boston, MA, USA.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Background: Larvicides are typically applied to fxed and fndable mosquito breeding sites, such as fsh farming ponds used in commercial aquaculture, to kill immature forms and thereby reduce the size of adult malaria vector populations. However, there is little evidence suggesting that larviciding may suppress community-wide malaria transmission outside Africa. Here, we tested whether the biological larvicide VectoMax FG applied at monthly intervals to fsh farming ponds can reduce malaria incidence in Amazonian Brazil. Methods: This study was carried out in Vila Assis Brasil (VAB; population 1700), a peri-urban malaria hotspot in northwestern Brazil with a baseline annual parasite incidence of 553 malaria cases per 1000 inhabitants. The interven‑ tion consisted of monthly treatments with 20 kg/ha of VectoMax FG of all water-flled fsh ponds in VAB (n ranging between 167 and 170) with a surface area between 20 and 8000 m2 , using knapsack power mistblowers. We used single-group interrupted time-series analysis to compare monthly larval density measurements in fsh ponds during a 14-month pre-intervention period (September 2017–October 2018), with measurements made during November 2018–October 2019 and shortly after the 12-month intervention (November 2019). We used interrupted time-series analysis with a comparison group to contrast the malaria incidence trends in VAB and nearby nonintervention locali‑ ties before and during the intervention. Results: Average larval densities decreased tenfold in treated fsh farming ponds, from 0.467 (95% confdence interval [CI], 0.444–0.490) anopheline larvae per dip pre-intervention (September 2017–October 2018) to 0.046 (95% CI, 0.041–0.051) larvae per dip during (November 2018–October 2019) and shortly after the intervention (Novem‑ ber 2019). Average malaria incidence rates decreased by 0.08 (95% CI, 0.04–0.11) cases per 100 person-months (P<0.0001) during the intervention in VAB and remained nearly unchanged in comparison localities. We estimate that the intervention averted 24.5 (95% CI, 6.2–42.8) malaria cases in VAB between January and December 2019. Conclusions: Regular larviciding is associated with a dramatic decrease in larval density and a modest but signifcant decrease in community-wide malaria incidence. Larviciding may provide a valuable complementary vector control strategy in commercial aquaculture settings across the Amazon.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48988/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSimoneL_Andrade3_etal_IOC_2021.pdfSimoneL_Andrade3_etal_IOC_2021.pdfapplication/pdf2555129https://www.arca.fiocruz.br/bitstream/icict/48988/2/SimoneL_Andrade3_etal_IOC_2021.pdfcfa36b9ea21e93e18397e13059bc099aMD52TEXTSimoneL_Andrade3_etal_IOC_2021.pdf.txtSimoneL_Andrade3_etal_IOC_2021.pdf.txtExtracted texttext/plain45988https://www.arca.fiocruz.br/bitstream/icict/48988/3/SimoneL_Andrade3_etal_IOC_2021.pdf.txt36c37942e155f781accda179a9d0399cMD53icict/489882021-09-06 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dc.title.pt_BR.fl_str_mv Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil
title Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil
spellingShingle Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil
Fontoura, Pablo S.
Malária
Anopheles
Larvicidas biológicos
Piscicultura
Amazonas
Malaria
Anopheles
Biological larvicides
Fish farming
Amazon
title_short Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil
title_full Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil
title_fullStr Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil
title_full_unstemmed Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil
title_sort Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil
author Fontoura, Pablo S.
author_facet Fontoura, Pablo S.
Silva, Marcos F.
Costa, Andreson S. da
Ribeiro, Francismar S.
Ferreira, Marcílio S.
Ladeia-Andrade, Simone
Tonini, Juliana
Rodrigues, Priscila T.
Castro, Marcia C.
Ferreira, Marcelo U.
author_role author
author2 Silva, Marcos F.
Costa, Andreson S. da
Ribeiro, Francismar S.
Ferreira, Marcílio S.
Ladeia-Andrade, Simone
Tonini, Juliana
Rodrigues, Priscila T.
Castro, Marcia C.
Ferreira, Marcelo U.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fontoura, Pablo S.
Silva, Marcos F.
Costa, Andreson S. da
Ribeiro, Francismar S.
Ferreira, Marcílio S.
Ladeia-Andrade, Simone
Tonini, Juliana
Rodrigues, Priscila T.
Castro, Marcia C.
Ferreira, Marcelo U.
dc.subject.other.pt_BR.fl_str_mv Malária
Anopheles
Larvicidas biológicos
Piscicultura
Amazonas
topic Malária
Anopheles
Larvicidas biológicos
Piscicultura
Amazonas
Malaria
Anopheles
Biological larvicides
Fish farming
Amazon
dc.subject.en.pt_BR.fl_str_mv Malaria
Anopheles
Biological larvicides
Fish farming
Amazon
description Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-05T14:39:33Z
dc.date.available.fl_str_mv 2021-09-05T14:39:33Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv FONTOURA, Pablo S. et al. Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil. Parasite & Vectors, v. 14, n. 445, 11 p, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48988
dc.identifier.issn.pt_BR.fl_str_mv 1756-3305
dc.identifier.doi.none.fl_str_mv 10.1186/s13071-021-04964-3
identifier_str_mv FONTOURA, Pablo S. et al. Monthly biological larviciding associated with a tenfold decrease in larval density in fsh farming ponds and reduced community-wide malaria incidence in northwestern Brazil. Parasite & Vectors, v. 14, n. 445, 11 p, 2021.
1756-3305
10.1186/s13071-021-04964-3
url https://www.arca.fiocruz.br/handle/icict/48988
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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https://www.arca.fiocruz.br/bitstream/icict/48988/2/SimoneL_Andrade3_etal_IOC_2021.pdf
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