Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56089 |
Resumo: | Texas Biomedical Research Institute. San Antonio, Texas, USA |
| id |
CRUZ_0a719646a7146899564c296660d9fdca |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/56089 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Platt, Roy N.Clec'h, Winka LeChevalier, Frédéric D.McDew‐White, MarinaLoVerde, Philip T.Assis, Rafael Ramiro deOliveira, Guilherme Corrêa deKinung'hi, SafariDjirmay, Amadou GarbaSteinauer, Michelle L.Gouvras, AnoukRabone, MurielAllan, FionaWebster, Bonnie L.Webster, Joanne P.Emery, Aidan M.Rollinson, DavidAnderson, Timothy J. C.2022-12-20T16:56:28Z2022-12-20T16:56:28Z2022PLATT, Roy N. et al. Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni. Mol Ecol.,v. 31, n. 8, p. 2242–2263, 2022. doi: 10.1111/mec.163950962-1083https://www.arca.fiocruz.br/handle/icict/56089engBlackwell Scientific PublicationsGenomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTexas Biomedical Research Institute. San Antonio, Texas, USATexas Biomedical Research Institute. San Antonio, Texas, USATexas Biomedical Research Institute. San Antonio, Texas, USATexas Biomedical Research Institute. San Antonio, Texas, USAUniversity of Texas Health Science Center. San Antonio Texas, USAFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ Instituto Tecnológico Vale. Belém, PA, BrazilNational Institute for Medical Research. Mwanza TanzaniaRéseau International Schistosomiases Environnemental Aménagement et Lutte (RISEAL), Niamey NigerWestern University of Heath Sciences. Corvallis, Oregon, USANatural History Museum. London, UKNatural History Museum. London, UKDepartment of Pathobiology and Population Sciences. Royal Veterinary College. Centre for Emerging, Endemic and Exotic Diseases. University of London. Hertfordshire, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UKNatural History Museum. London, UK/ London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UKDepartment of Pathobiology and Population Sciences. Royal Veterinary College. Centre for Emerging. Endemic and Exotic Diseases. University of London. Hertfordshire, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UKNatural History Museum. London, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UKNatural History Museum. London, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UKTexas Biomedical Research Institute. San Antonio. Texas, USASchistosoma mansoni, a snail‐borne, blood fluke that infects humans, was introduced into the Americas from Africa during the Trans‐Atlantic slave trade. As this parasite shows strong specificity to the snail intermediate host, we expected that adaptation to South American Biomphalaria spp. snails would result in population bottlenecks and strong signatures of selection. We scored 475,081 single nucleotide variants in 143 S. mansoni from the Americas (Brazil, Guadeloupe and Puerto Rico) and Africa (Cameroon, Niger, Senegal, Tanzania, and Uganda), and used these data to ask: (i) Was there a population bottleneck during colonization? (ii) Can we identify signatures of selection associated with colonization? (iii) What were the source populations for colonizing parasites? We found a 2.4‐ to 2.9‐fold reduction in diversity and much slower decay in linkage disequilibrium (LD) in parasites from East to West Africa. However, we observed similar nuclear diversity and LD in West Africa and Brazil, suggesting no strong bottlenecks and limited barriers to colonization. We identified five genome regions showing selection in the Americas, compared with three in West Africa and none in East Africa, which we speculate may reflect adaptation during colonization. Finally, we infer that unsampled populations from central African regions between Benin and Angola, with contributions from Niger, are probably the major source(s) for Brazilian S. mansoni. The absence of a bottleneck suggests that this is a rare case of a serendipitous invasion, where S. mansoni parasites were pre‐adapted to the Americas and able to establish with relative ease.AfricaBrazilcodispersalexomehuman parasitemigrationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56089/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGenomic analysis of a parasite invasion.pdfGenomic analysis of a parasite invasion.pdfapplication/pdf2302896https://www.arca.fiocruz.br/bitstream/icict/56089/2/Genomic%20analysis%20of%20a%20parasite%20invasion.pdf755bc0489427208b7224cf6bf680e57aMD52icict/560892022-12-20 13:56:28.748oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-12-20T16:56:28Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni |
| title |
Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni |
| spellingShingle |
Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni Platt, Roy N. Africa Brazil codispersal exome human parasite migration |
| title_short |
Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni |
| title_full |
Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni |
| title_fullStr |
Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni |
| title_full_unstemmed |
Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni |
| title_sort |
Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni |
| author |
Platt, Roy N. |
| author_facet |
Platt, Roy N. Clec'h, Winka Le Chevalier, Frédéric D. McDew‐White, Marina LoVerde, Philip T. Assis, Rafael Ramiro de Oliveira, Guilherme Corrêa de Kinung'hi, Safari Djirmay, Amadou Garba Steinauer, Michelle L. Gouvras, Anouk Rabone, Muriel Allan, Fiona Webster, Bonnie L. Webster, Joanne P. Emery, Aidan M. Rollinson, David Anderson, Timothy J. C. |
| author_role |
author |
| author2 |
Clec'h, Winka Le Chevalier, Frédéric D. McDew‐White, Marina LoVerde, Philip T. Assis, Rafael Ramiro de Oliveira, Guilherme Corrêa de Kinung'hi, Safari Djirmay, Amadou Garba Steinauer, Michelle L. Gouvras, Anouk Rabone, Muriel Allan, Fiona Webster, Bonnie L. Webster, Joanne P. Emery, Aidan M. Rollinson, David Anderson, Timothy J. C. |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Platt, Roy N. Clec'h, Winka Le Chevalier, Frédéric D. McDew‐White, Marina LoVerde, Philip T. Assis, Rafael Ramiro de Oliveira, Guilherme Corrêa de Kinung'hi, Safari Djirmay, Amadou Garba Steinauer, Michelle L. Gouvras, Anouk Rabone, Muriel Allan, Fiona Webster, Bonnie L. Webster, Joanne P. Emery, Aidan M. Rollinson, David Anderson, Timothy J. C. |
| dc.subject.en.en_US.fl_str_mv |
Africa Brazil codispersal exome human parasite migration |
| topic |
Africa Brazil codispersal exome human parasite migration |
| description |
Texas Biomedical Research Institute. San Antonio, Texas, USA |
| publishDate |
2022 |
| dc.date.accessioned.fl_str_mv |
2022-12-20T16:56:28Z |
| dc.date.available.fl_str_mv |
2022-12-20T16:56:28Z |
| dc.date.issued.fl_str_mv |
2022 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
PLATT, Roy N. et al. Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni. Mol Ecol.,v. 31, n. 8, p. 2242–2263, 2022. doi: 10.1111/mec.16395 |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/56089 |
| dc.identifier.issn.en_US.fl_str_mv |
0962-1083 |
| identifier_str_mv |
PLATT, Roy N. et al. Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni. Mol Ecol.,v. 31, n. 8, p. 2242–2263, 2022. doi: 10.1111/mec.16395 0962-1083 |
| url |
https://www.arca.fiocruz.br/handle/icict/56089 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Blackwell Scientific Publications |
| publisher.none.fl_str_mv |
Blackwell Scientific Publications |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/56089/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/56089/2/Genomic%20analysis%20of%20a%20parasite%20invasion.pdf |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 755bc0489427208b7224cf6bf680e57a |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1822791966131224576 |