Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs)

Detalhes bibliográficos
Autor(a) principal: Peixoto, Bárbara Costa
Data de Publicação: 2016
Outros Autores: Peixoto, Leonardo Chicaybam, Bonamino, Martin Hernán
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28164
Resumo: Instituto Nacional de Câncer José Alencar Gomes da Silva. Programa de Caricinogênese Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Peixoto, Bárbara CostaPeixoto, Leonardo ChicaybamBonamino, Martin Hernán2018-08-15T19:18:34Z2018-08-15T19:18:34Z2016PEIXOTO, B. C.; PEIXOTO, L. C.; BONAMINO, M. H. Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs). In: SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 4., 2016, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2016. p. 172-173.https://www.arca.fiocruz.br/handle/icict/2816410.35259/isi.sact.2016_28164engFiocruz/Instituto de Tecnologia em ImunobiológicosImunoterapiaReceptores inibitóriosCRISPRCas9SACTImmunotherapyInhibitory receptorsCRISPRCas9ImunoterapiaGenomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectInstituto Nacional de Câncer José Alencar Gomes da Silva. Programa de Caricinogênese Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Vice-Presidência de Pesquisa e Laboratórios de Referência. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Vice-Presidência de Pesquisa e Laboratórios de Referência. Rio de Janeiro, RJ, Brasil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/28164/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALIV SACT _ OTR5.pdfIV SACT _ OTR5.pdfapplication/pdf51957https://www.arca.fiocruz.br/bitstream/icict/28164/2/IV%20SACT%20_%20OTR5.pdf7b84c3e29c39ce22f34121196d9a576eMD52TEXTIV SACT _ OTR5.pdf.txtIV SACT _ OTR5.pdf.txtExtracted texttext/plain3099https://www.arca.fiocruz.br/bitstream/icict/28164/3/IV%20SACT%20_%20OTR5.pdf.txtf9c01f468460d51e2041102f40890e4dMD53icict/281642023-04-26 17:04:40.411oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-26T20:04:40Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs)
title Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs)
spellingShingle Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs)
Peixoto, Bárbara Costa
Imunoterapia
Receptores inibitórios
CRISPRCas9
SACT
Immunotherapy
Inhibitory receptors
CRISPRCas9
Imunoterapia
title_short Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs)
title_full Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs)
title_fullStr Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs)
title_full_unstemmed Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs)
title_sort Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs)
author Peixoto, Bárbara Costa
author_facet Peixoto, Bárbara Costa
Peixoto, Leonardo Chicaybam
Bonamino, Martin Hernán
author_role author
author2 Peixoto, Leonardo Chicaybam
Bonamino, Martin Hernán
author2_role author
author
dc.contributor.author.fl_str_mv Peixoto, Bárbara Costa
Peixoto, Leonardo Chicaybam
Bonamino, Martin Hernán
dc.subject.other.pt_BR.fl_str_mv Imunoterapia
Receptores inibitórios
CRISPRCas9
SACT
topic Imunoterapia
Receptores inibitórios
CRISPRCas9
SACT
Immunotherapy
Inhibitory receptors
CRISPRCas9
Imunoterapia
dc.subject.en.pt_BR.fl_str_mv Immunotherapy
Inhibitory receptors
CRISPRCas9
dc.subject.decs.pt_BR.fl_str_mv Imunoterapia
description Instituto Nacional de Câncer José Alencar Gomes da Silva. Programa de Caricinogênese Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2018-08-15T19:18:34Z
dc.date.available.fl_str_mv 2018-08-15T19:18:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEIXOTO, B. C.; PEIXOTO, L. C.; BONAMINO, M. H. Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs). In: SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 4., 2016, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2016. p. 172-173.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28164
dc.identifier.doi.none.fl_str_mv 10.35259/isi.sact.2016_28164
identifier_str_mv PEIXOTO, B. C.; PEIXOTO, L. C.; BONAMINO, M. H. Genomic editing, mediated by CRISPR/Cas9, of PDCD1, CTLA4 e LAG3 loci in T lymphocytes expressing Chimeric Antigens Receptor (CARs). In: SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 4., 2016, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2016. p. 172-173.
10.35259/isi.sact.2016_28164
url https://www.arca.fiocruz.br/handle/icict/28164
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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