Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1

Detalhes bibliográficos
Autor(a) principal: Lima, Luciane Mota
Data de Publicação: 2013
Outros Autores: Santos, Silvane Braga, Oliveira, Ricardo Riccio, Cardoso, Luciana Santos, Oliveira, Sérgio Costa, Góes, Alfredo Miranda, Loukas, Alex, Carvalho Filho, Edgar Marcelino, Araújo, Maria Ilma
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19018
Resumo: Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Lima, Luciane MotaSantos, Silvane BragaOliveira, Ricardo RiccioCardoso, Luciana SantosOliveira, Sérgio CostaGóes, Alfredo MirandaLoukas, AlexCarvalho Filho, Edgar MarcelinoAraújo, Maria Ilma2017-05-26T16:36:52Z2017-05-26T16:36:52Z2013LIMA, L. M. et al. Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1. Neuroimmunomodulation, v. 20, p. 233–238, 2013.1021-7401https://www.arca.fiocruz.br/handle/icict/1901810.1159/000348700Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.CNPQ (Universal 479417/2008 3) and NIH (R01AI079238A).Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Ciências da Vida. Salvador, BA, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de BioquÍmica e Imunologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de BioquÍmica e Imunologia. Belo Horizonte, MG, BrasilQueensland Institute of Medical Research. Division of Infectious Diseases. Brisbane, Qld, AustraliaUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, BrasilHuman T cell lymphotropic virus type 1 (HTLV-1) is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). While the immune response to HTLV-1 infection is polarized to the Th1-type, chronic helminth infections drive the Th2- and T regulatory-type, and are able to downregulate the inflammatory response in some autoimmune diseases. Objective: To evaluate whether Schistosoma spp. antigens alter the in vitro cytokine response in HTLV-1 infection. Methods: The recombinant Schistosoma antigens Sm29 and ShTSP2 (tetraspanin) and PIII, a fraction of the Schistosoma mansoni adult worm antigen were added to peripheral blood mononuclear cell (PBMC) cultures of HTLV-1-infected individuals and the levels of interferon (IFN)-γ and interleukin (IL)-10 in the supernatants were measured using the ELISA sandwich technique. Results: Compared to the levels of cytokine in nonstimulated cultures, the levels of IFN-γ were reduced in 50, 47 and 50% of patients by the presence of Sm29, ShTsp2 and PIII, respectively. The downregulation of IFN-γ production in the presence of Sm29 antigen was observed mainly in subjects who had lower basal levels of this cytokine. The levels of IL-10, however, increased by the addition of the three antigens in the cultures in 74, 62 and 44% of individuals, respectively. In addition, there was a decrease in the ratio of IFN-γ/ IL-10 levels in cultures stimulated with Sm29 and ShTSP2 when compared to nonstimulated ones. Conclusions: The Schistosoma spp. antigens used in this study were able to downmodulate IFN-γ production in vitro in HTLV-1 infection. This may be associated with the increased levels of IL-10 induced by the antigens.engKarger PublishersVírus linfotrópico de células T humanas tipo 1Schistosoma spp. AntígenosInterferon-yInterleucina-10AntígenosHuman T cell lymphotropic virus type 1Schistosoma sppInterferon-γInterleukin-10AntigensVírus linfotrópico de células T humanas tipo 1SchistosomaInterferonInterleucina-10AntígenosSchistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19018/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLima, LM Schistosoma antigens downmodulate the in vitro.....pdfLima, LM Schistosoma antigens 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dc.title.pt_BR.fl_str_mv Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1
title Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1
spellingShingle Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1
Lima, Luciane Mota
Vírus linfotrópico de células T humanas tipo 1
Schistosoma spp. Antígenos
Interferon-y
Interleucina-10
Antígenos
Human T cell lymphotropic virus type 1
Schistosoma spp
Interferon-γ
Interleukin-10
Antigens
Vírus linfotrópico de células T humanas tipo 1
Schistosoma
Interferon
Interleucina-10
Antígenos
title_short Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1
title_full Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1
title_fullStr Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1
title_full_unstemmed Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1
title_sort Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1
author Lima, Luciane Mota
author_facet Lima, Luciane Mota
Santos, Silvane Braga
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Oliveira, Sérgio Costa
Góes, Alfredo Miranda
Loukas, Alex
Carvalho Filho, Edgar Marcelino
Araújo, Maria Ilma
author_role author
author2 Santos, Silvane Braga
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Oliveira, Sérgio Costa
Góes, Alfredo Miranda
Loukas, Alex
Carvalho Filho, Edgar Marcelino
Araújo, Maria Ilma
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Luciane Mota
Santos, Silvane Braga
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Oliveira, Sérgio Costa
Góes, Alfredo Miranda
Loukas, Alex
Carvalho Filho, Edgar Marcelino
Araújo, Maria Ilma
dc.subject.other.pt_BR.fl_str_mv Vírus linfotrópico de células T humanas tipo 1
Schistosoma spp. Antígenos
Interferon-y
Interleucina-10
Antígenos
topic Vírus linfotrópico de células T humanas tipo 1
Schistosoma spp. Antígenos
Interferon-y
Interleucina-10
Antígenos
Human T cell lymphotropic virus type 1
Schistosoma spp
Interferon-γ
Interleukin-10
Antigens
Vírus linfotrópico de células T humanas tipo 1
Schistosoma
Interferon
Interleucina-10
Antígenos
dc.subject.en.pt_BR.fl_str_mv Human T cell lymphotropic virus type 1
Schistosoma spp
Interferon-γ
Interleukin-10
Antigens
dc.subject.decs.pt_BR.fl_str_mv Vírus linfotrópico de células T humanas tipo 1
Schistosoma
Interferon
Interleucina-10
Antígenos
description Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2017-05-26T16:36:52Z
dc.date.available.fl_str_mv 2017-05-26T16:36:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, L. M. et al. Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1. Neuroimmunomodulation, v. 20, p. 233–238, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19018
dc.identifier.issn.pt_BR.fl_str_mv 1021-7401
dc.identifier.doi.none.fl_str_mv 10.1159/000348700
identifier_str_mv LIMA, L. M. et al. Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1. Neuroimmunomodulation, v. 20, p. 233–238, 2013.
1021-7401
10.1159/000348700
url https://www.arca.fiocruz.br/handle/icict/19018
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Karger Publishers
publisher.none.fl_str_mv Karger Publishers
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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