Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response

Detalhes bibliográficos
Autor(a) principal: Provenzano, Bruna Cuoco
Data de Publicação: 2023
Outros Autores: Bartholo, Thiago Prudente, Kirk, Kennedy Martins, Neves, Mario Fritsch, Ribeiro-Alves, Marcelo, Barreto, Ana Paula Ramos, Graça, Nadja Polisseni, Coelho, Paulo Roberto Chauvet, Costa, Claudia Henrique da, Rufino, Rogerio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60637
Resumo: Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
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spelling Provenzano, Bruna CuocoBartholo, Thiago PrudenteKirk, Kennedy MartinsNeves, Mario FritschRibeiro-Alves, MarceloBarreto, Ana Paula RamosGraça, Nadja PolisseniCoelho, Paulo Roberto ChauvetCosta, Claudia Henrique daRufino, Rogerio2023-09-30T19:32:11Z2023-09-30T19:32:11Z2023PROVENZANO, Bruna Cuoco et al. Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response. Medicine, v. 102, n. 28, p. 1-5, jul. 2023.0025-7974https://www.arca.fiocruz.br/handle/icict/6063710.1097/MD.00000000000340731536-5964engLippincott Williams & WilkinsUse of fractional exhaled nitric oxide as a potential predictor of bronchodilator responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Nitric oxide (NO) is an important product of eosinophilic metabolism, and its increase is associated with bronchial remodeling and airway hyperresponsiveness. Fractional exhaled NO (FENO) in the expired air of patients with suspected or diagnosed asthma has been used as a marker for eosinophilic inflammation. This cohort study included asthmatic patients classified under steps 3, 4, or 5 of the global strategy for asthma management and prevention. In the morning of the same day, all patien ts underwent blood collection for eosinophil counts, followed by FENO measurement and spirometry. We considered 2 groups based on the bronchodilation (BD) response on spirometry (>10% of FVC or FEV1 ): positive (BD+) and negative (BD−). Differences between the 2 groups were analyzed for demographic features, FENO values, and predictive correlations between FENO and BD. Both groups of patients showed an increase in the eosinophil count (BD+, P = .03; BD−, P = .04) and FENO values (P = .015 for both) with an increase in the asthma severity from step 3 to step 5 of the global strategy for asthma management and prevention. The correlations of FENO and eosinophils as well as FENO values and BD + were 0.127 (95% confidence interval,–0.269 to –0.486) and 0.696 (95% confidence interval, 0.246–0.899; P = .007), respectively. Measuring FENO levels may be useful for identifying patients with BD+. Abbreviations: ATS = American Thoracic Society, BD = bronchodilation, BMI = body mass index, CI = confidence intervals, FENO = Fractional Exhaled Nitric Oxide, FEV1 = Forced Expiratory Volume in One Second, FVC = Forced Vital Capacity, GINA = Global Strategy for Asthma Management and Prevention, NO = nitric oxide.AsthmaBiomarkersFractional exhaled nitric oxide testingMonitoringinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60637/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Bruna_ Provenzano_etal_INI_2023.pdfve_Bruna_ Provenzano_etal_INI_2023.pdfapplication/pdf522795https://www.arca.fiocruz.br/bitstream/icict/60637/2/ve_Bruna_%20Provenzano_etal_INI_2023.pdf13a99fa8e4e8cd719a42fa9837c53d30MD52icict/606372023-09-30 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dc.title.en_US.fl_str_mv Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response
title Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response
spellingShingle Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response
Provenzano, Bruna Cuoco
Asthma
Biomarkers
Fractional exhaled nitric oxide testing
Monitoring
title_short Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response
title_full Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response
title_fullStr Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response
title_full_unstemmed Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response
title_sort Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response
author Provenzano, Bruna Cuoco
author_facet Provenzano, Bruna Cuoco
Bartholo, Thiago Prudente
Kirk, Kennedy Martins
Neves, Mario Fritsch
Ribeiro-Alves, Marcelo
Barreto, Ana Paula Ramos
Graça, Nadja Polisseni
Coelho, Paulo Roberto Chauvet
Costa, Claudia Henrique da
Rufino, Rogerio
author_role author
author2 Bartholo, Thiago Prudente
Kirk, Kennedy Martins
Neves, Mario Fritsch
Ribeiro-Alves, Marcelo
Barreto, Ana Paula Ramos
Graça, Nadja Polisseni
Coelho, Paulo Roberto Chauvet
Costa, Claudia Henrique da
Rufino, Rogerio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Provenzano, Bruna Cuoco
Bartholo, Thiago Prudente
Kirk, Kennedy Martins
Neves, Mario Fritsch
Ribeiro-Alves, Marcelo
Barreto, Ana Paula Ramos
Graça, Nadja Polisseni
Coelho, Paulo Roberto Chauvet
Costa, Claudia Henrique da
Rufino, Rogerio
dc.subject.en.en_US.fl_str_mv Asthma
Biomarkers
Fractional exhaled nitric oxide testing
Monitoring
topic Asthma
Biomarkers
Fractional exhaled nitric oxide testing
Monitoring
description Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-09-30T19:32:11Z
dc.date.available.fl_str_mv 2023-09-30T19:32:11Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PROVENZANO, Bruna Cuoco et al. Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response. Medicine, v. 102, n. 28, p. 1-5, jul. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60637
dc.identifier.issn.en_US.fl_str_mv 0025-7974
dc.identifier.doi.none.fl_str_mv 10.1097/MD.0000000000034073
dc.identifier.eissn.none.fl_str_mv 1536-5964
identifier_str_mv PROVENZANO, Bruna Cuoco et al. Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response. Medicine, v. 102, n. 28, p. 1-5, jul. 2023.
0025-7974
10.1097/MD.0000000000034073
1536-5964
url https://www.arca.fiocruz.br/handle/icict/60637
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/60637/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/60637/2/ve_Bruna_%20Provenzano_etal_INI_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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