PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

Detalhes bibliográficos
Autor(a) principal: Kauffman, Keith D
Data de Publicação: 2020
Outros Autores: Sakai, Shunsuke, Lora, Nickiana E, Namasivayam, Sivaranjani, Baker, Paul J, Kamenyeva, Olena, Foreman, Taylor W, Nelson, Christine E, Souza, Deivide Oliveira de, Vinhaes, Caian L., Yaniv, Ziv, Arleham, Cecilia S Lindestam, Sette, Alessandro, Freeman, Gordon J, Moore, Rashida, the NIAID/DIR Tuberculosis Imaging Program, Sher, Alan, Barber, Katrin D Mayer, Andrade, Bruno de Bezerril, Kabat, Juraj, Via, Laura E, Barber, Daniel L
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46319
Resumo: 1 T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 2 Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 3 Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA 4 Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 5 Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Intituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil 6 Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 7 Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, California, USA 8 Department of Medicine, University of California San Diego, La Jolla, California, USA 9 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA 10 Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 11 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 12 Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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spelling Kauffman, Keith DSakai, ShunsukeLora, Nickiana ENamasivayam, SivaranjaniBaker, Paul JKamenyeva, OlenaForeman, Taylor WNelson, Christine ESouza, Deivide Oliveira deVinhaes, Caian L.Yaniv, ZivArleham, Cecilia S LindestamSette, AlessandroFreeman, Gordon JMoore, Rashidathe NIAID/DIR Tuberculosis Imaging ProgramSher, AlanBarber, Katrin D MayerAndrade, Bruno de BezerrilKabat, JurajVia, Laura EBarber, Daniel L2021-03-10T12:14:58Z2021-03-10T12:14:58Z2020KAUFFMAN, Keith D. et al. PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques. Science Immunology, 2020.https://www.arca.fiocruz.br/handle/icict/463191 T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 2 Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 3 Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA 4 Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 5 Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Intituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil 6 Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 7 Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, California, USA 8 Department of Medicine, University of California San Diego, La Jolla, California, USA 9 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA 10 Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 11 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 12 Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"Múltipla ver em Notas"Boosting immune cell function by targeting the co-inhibitory receptor PD-1 may have applications in the treatment of chronic infections. Here we examine the role of PD-1 during Mycobacterium tuberculosis (Mtb) infection of rhesus macaques. Animals treated with αPD-1 mAb developed worse disease and higher granuloma bacterial loads compared to isotype control treated monkeys. PD-1 blockade increased the number and functionality of granuloma Mtbspecific CD8 T cells. In contrast, Mtb-specific CD4 T cells in αPD-1 treated macaques were not increased in number or function in granulomas, upregulated high levels of CTLA-4 and exhibited reduced intralesional trafficking in live imaging studies. In granulomas of αPD-1 treated animals, multiple pro-inflammatory cytokines were elevated, and more cytokines correlated with bacterial loads, leading to the identification of a role for caspase 1 in the exacerbation of tuberculosis after PD-1 blockade. Lastly, increased Mtb bacterial loads after PD-1 blockade were found to associate with the composition of the intestinal microbiota prior to infection in individual macaques. Therefore, PD-1-mediated co-inhibition is required for control of Mtb infection in macaques, perhaps due to its role in dampening detrimental inflammation as well as allowing for normal CD4 T cell responsesengAmerican Association for the Advancement of ScienceMycobacterium tuberculosisInflamaçãoCitocinasTuberculoseGranulomaMycobacterium tuberculosisInflammationCytokinesTuberculosisGranulomaPD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaquesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46319/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKauffman, D Keith. PD-1 blockade.pdfKauffman, D Keith. 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dc.title.pt_BR.fl_str_mv PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
title PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
spellingShingle PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
Kauffman, Keith D
Mycobacterium tuberculosis
Inflamação
Citocinas
Tuberculose
Granuloma
Mycobacterium tuberculosis
Inflammation
Cytokines
Tuberculosis
Granuloma
title_short PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
title_full PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
title_fullStr PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
title_full_unstemmed PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
title_sort PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
author Kauffman, Keith D
author_facet Kauffman, Keith D
Sakai, Shunsuke
Lora, Nickiana E
Namasivayam, Sivaranjani
Baker, Paul J
Kamenyeva, Olena
Foreman, Taylor W
Nelson, Christine E
Souza, Deivide Oliveira de
Vinhaes, Caian L.
Yaniv, Ziv
Arleham, Cecilia S Lindestam
Sette, Alessandro
Freeman, Gordon J
Moore, Rashida
the NIAID/DIR Tuberculosis Imaging Program
Sher, Alan
Barber, Katrin D Mayer
Andrade, Bruno de Bezerril
Kabat, Juraj
Via, Laura E
Barber, Daniel L
author_role author
author2 Sakai, Shunsuke
Lora, Nickiana E
Namasivayam, Sivaranjani
Baker, Paul J
Kamenyeva, Olena
Foreman, Taylor W
Nelson, Christine E
Souza, Deivide Oliveira de
Vinhaes, Caian L.
Yaniv, Ziv
Arleham, Cecilia S Lindestam
Sette, Alessandro
Freeman, Gordon J
Moore, Rashida
the NIAID/DIR Tuberculosis Imaging Program
Sher, Alan
Barber, Katrin D Mayer
Andrade, Bruno de Bezerril
Kabat, Juraj
Via, Laura E
Barber, Daniel L
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kauffman, Keith D
Sakai, Shunsuke
Lora, Nickiana E
Namasivayam, Sivaranjani
Baker, Paul J
Kamenyeva, Olena
Foreman, Taylor W
Nelson, Christine E
Souza, Deivide Oliveira de
Vinhaes, Caian L.
Yaniv, Ziv
Arleham, Cecilia S Lindestam
Sette, Alessandro
Freeman, Gordon J
Moore, Rashida
the NIAID/DIR Tuberculosis Imaging Program
Sher, Alan
Barber, Katrin D Mayer
Andrade, Bruno de Bezerril
Kabat, Juraj
Via, Laura E
Barber, Daniel L
dc.subject.other.pt_BR.fl_str_mv Mycobacterium tuberculosis
Inflamação
Citocinas
Tuberculose
Granuloma
topic Mycobacterium tuberculosis
Inflamação
Citocinas
Tuberculose
Granuloma
Mycobacterium tuberculosis
Inflammation
Cytokines
Tuberculosis
Granuloma
dc.subject.en.pt_BR.fl_str_mv Mycobacterium tuberculosis
Inflammation
Cytokines
Tuberculosis
Granuloma
description 1 T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 2 Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 3 Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA 4 Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 5 Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Intituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil 6 Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 7 Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, California, USA 8 Department of Medicine, University of California San Diego, La Jolla, California, USA 9 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA 10 Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 11 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 12 Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-03-10T12:14:58Z
dc.date.available.fl_str_mv 2021-03-10T12:14:58Z
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dc.identifier.citation.fl_str_mv KAUFFMAN, Keith D. et al. PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques. Science Immunology, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46319
identifier_str_mv KAUFFMAN, Keith D. et al. PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques. Science Immunology, 2020.
url https://www.arca.fiocruz.br/handle/icict/46319
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