Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus

Detalhes bibliográficos
Autor(a) principal: Agwale, Simon M.
Data de Publicação: 1998
Outros Autores: Duhlinska, Dockha D., Grimaldi Jr., Gabriel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43919
Resumo: University of Jos. Department of Zoology. Jos, Plateau State, Nigeria.
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spelling Agwale, Simon M.Duhlinska, Dockha D.Grimaldi Jr., Gabriel2020-10-11T19:15:50Z2020-10-11T19:15:50Z1998AGWALE, Simon M.; DUHLINSKA, Dockha; GRIMALDI JR., Gabriel. Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, n. 1, p. 23-27, Jan./Feb. 1998.0074-0276https://www.arca.fiocruz.br/handle/icict/4391910.1590/S0074-027619980001000051678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.LeishmanioseLeishmaniose cutâneaImunoprevalênciaLeishmania maiorNigériaLeishmaniasisCutaneous leishmaniasisLeishmania majorimmunoprevalenceNigeriaResponse to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Jos. Department of Zoology. Jos, Plateau State, Nigeria.University of Jos. Department of Zoology. Jos, Plateau State, Nigeria.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.A pilot study was undertaken to preliminary illustrate the leishmanin skin test (LST) positivity to distinct antigen preparations (derived from promastigote of either Leishmania major or L. amazonensis, or pooled L. mexicana, L. amazonensis and L. guyanensis) in cutaneous leishmaniasis (CL) patients and healthy subjects living in two endemic foci in Nigeria. The study was designed to provide insights into whether cross-species leishmanin, such as that prepared from New World Leishmania could be useful to detect cases of Old World leishmanial infection and to compare the results with LST using L. major-derived leishmanin. The overall LST positivity in individuals from Keana tested with the cross-species leishmanin was 28.7% (27/94), while the positivity rate in the subjects from Kanana tested with the same leishmanin was 54.5% (6/11). Lower positivity values were obtained when L. major (12.5%; 11/88) or L. amazonensis (15.8%; 9/57) was tested as antigen in grossly comparable populations. Moreover, the pooled leishmanin identified most of the subjects (13/14; 92.9%) with active or healed CL, and the maximum reaction sizes were found among positive subjects in this group. No healthy controls (10 total) showed specific DTH response. The LST was useful for assessing the prevalence of subclinical infection and for measuring CL transmission over time. We report for the first time the occurrence of CL in Kanana village of Langtang South local government area of Plateau State.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGabriel_GrimaldiJr_etal_IOC_1998.pdfGabriel_GrimaldiJr_etal_IOC_1998.pdfapplication/pdf81721https://www.arca.fiocruz.br/bitstream/icict/43919/2/Gabriel_GrimaldiJr_etal_IOC_1998.pdfe5cabf1e3203de50987e3197d7af1a59MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43919/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTGabriel_GrimaldiJr_etal_IOC_1998.pdf.txtGabriel_GrimaldiJr_etal_IOC_1998.pdf.txtExtracted texttext/plain24924https://www.arca.fiocruz.br/bitstream/icict/43919/4/Gabriel_GrimaldiJr_etal_IOC_1998.pdf.txtab405e226571e6a4a8af671acee93929MD54icict/439192022-06-24 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dc.title.pt_BR.fl_str_mv Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus
title Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus
spellingShingle Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus
Agwale, Simon M.
Leishmaniose
Leishmaniose cutânea
Imunoprevalência
Leishmania maior
Nigéria
Leishmaniasis
Cutaneous leishmaniasis
Leishmania major
immunoprevalence
Nigeria
title_short Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus
title_full Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus
title_fullStr Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus
title_full_unstemmed Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus
title_sort Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus
author Agwale, Simon M.
author_facet Agwale, Simon M.
Duhlinska, Dockha D.
Grimaldi Jr., Gabriel
author_role author
author2 Duhlinska, Dockha D.
Grimaldi Jr., Gabriel
author2_role author
author
dc.contributor.author.fl_str_mv Agwale, Simon M.
Duhlinska, Dockha D.
Grimaldi Jr., Gabriel
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Leishmaniose cutânea
Imunoprevalência
Leishmania maior
Nigéria
topic Leishmaniose
Leishmaniose cutânea
Imunoprevalência
Leishmania maior
Nigéria
Leishmaniasis
Cutaneous leishmaniasis
Leishmania major
immunoprevalence
Nigeria
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Cutaneous leishmaniasis
Leishmania major
immunoprevalence
Nigeria
description University of Jos. Department of Zoology. Jos, Plateau State, Nigeria.
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2020-10-11T19:15:50Z
dc.date.available.fl_str_mv 2020-10-11T19:15:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv AGWALE, Simon M.; DUHLINSKA, Dockha; GRIMALDI JR., Gabriel. Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, n. 1, p. 23-27, Jan./Feb. 1998.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43919
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761998000100005
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv AGWALE, Simon M.; DUHLINSKA, Dockha; GRIMALDI JR., Gabriel. Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, n. 1, p. 23-27, Jan./Feb. 1998.
0074-0276
10.1590/S0074-02761998000100005
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43919
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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