Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy

Detalhes bibliográficos
Autor(a) principal: Albuquerque, Cassiano Felippe Gonçalves de
Data de Publicação: 2017
Outros Autores: Silva, Adriana Ribeiro, Silva, Camila Ignácio da, Faria Neto, Hugo Caire de Castro, Burth, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23297
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil
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spelling Albuquerque, Cassiano Felippe Gonçalves deSilva, Adriana RibeiroSilva, Camila Ignácio daFaria Neto, Hugo Caire de CastroBurth, Patrícia2017-11-21T16:36:33Z2017-11-21T16:36:33Z2017ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy. Moelcules, v.22:578, 18p, 2017.https://www.arca.fiocruz.br/handle/icict/2329710.3390/molecules220405781420-3049engMDPIApoptoseAutofagiaCarcinoma Pulmonar de Células não PequenasGlicosídeos CardíacosNa/K-ATPasenon-small cell lung cancerapoptosisautophagycardiotonic steroidsNa/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Enzimologia e Sinalização Celular. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Enzimologia e Sinalização Celular. Niterói, RJ, Brasil.Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23297/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcassiano_albuquerque_etal_IOC_2017.pdfcassiano_albuquerque_etal_IOC_2017.pdfapplication/pdf1297250https://www.arca.fiocruz.br/bitstream/icict/23297/2/cassiano_albuquerque_etal_IOC_2017.pdf52adfdd10a39f6337dba261eb5a5d466MD52TEXTcassiano_albuquerque_etal_IOC_2017.pdf.txtcassiano_albuquerque_etal_IOC_2017.pdf.txtExtracted texttext/plain79324https://www.arca.fiocruz.br/bitstream/icict/23297/3/cassiano_albuquerque_etal_IOC_2017.pdf.txt3b80cab0df4c3c81f299238f0a088e01MD53icict/232972018-08-15 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dc.title.pt_BR.fl_str_mv Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy
title Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy
spellingShingle Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy
Albuquerque, Cassiano Felippe Gonçalves de
Apoptose
Autofagia
Carcinoma Pulmonar de Células não Pequenas
Glicosídeos Cardíacos
Na/K-ATPase
non-small cell lung cancer
apoptosis
autophagy
cardiotonic steroids
title_short Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy
title_full Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy
title_fullStr Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy
title_full_unstemmed Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy
title_sort Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy
author Albuquerque, Cassiano Felippe Gonçalves de
author_facet Albuquerque, Cassiano Felippe Gonçalves de
Silva, Adriana Ribeiro
Silva, Camila Ignácio da
Faria Neto, Hugo Caire de Castro
Burth, Patrícia
author_role author
author2 Silva, Adriana Ribeiro
Silva, Camila Ignácio da
Faria Neto, Hugo Caire de Castro
Burth, Patrícia
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Albuquerque, Cassiano Felippe Gonçalves de
Silva, Adriana Ribeiro
Silva, Camila Ignácio da
Faria Neto, Hugo Caire de Castro
Burth, Patrícia
dc.subject.other.pt_BR.fl_str_mv Apoptose
Autofagia
Carcinoma Pulmonar de Células não Pequenas
Glicosídeos Cardíacos
topic Apoptose
Autofagia
Carcinoma Pulmonar de Células não Pequenas
Glicosídeos Cardíacos
Na/K-ATPase
non-small cell lung cancer
apoptosis
autophagy
cardiotonic steroids
dc.subject.en.pt_BR.fl_str_mv Na/K-ATPase
non-small cell lung cancer
apoptosis
autophagy
cardiotonic steroids
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-11-21T16:36:33Z
dc.date.available.fl_str_mv 2017-11-21T16:36:33Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy. Moelcules, v.22:578, 18p, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23297
dc.identifier.doi.none.fl_str_mv 10.3390/molecules22040578
dc.identifier.eissn.none.fl_str_mv 1420-3049
identifier_str_mv ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy. Moelcules, v.22:578, 18p, 2017.
10.3390/molecules22040578
1420-3049
url https://www.arca.fiocruz.br/handle/icict/23297
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/23297/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/23297/2/cassiano_albuquerque_etal_IOC_2017.pdf
https://www.arca.fiocruz.br/bitstream/icict/23297/3/cassiano_albuquerque_etal_IOC_2017.pdf.txt
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