Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region

Detalhes bibliográficos
Autor(a) principal: Freitas, Silvia Regina Sampaio
Data de Publicação: 2007
Outros Autores: Cabello, Pedro Hernan, Moura Neto, Rodrigo Soares, Dolinsky, Luciana Cresta, Bóia, Márcio Neves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41189
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
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spelling Freitas, Silvia Regina SampaioCabello, Pedro HernanMoura Neto, Rodrigo SoaresDolinsky, Luciana CrestaBóia, Márcio Neves2020-05-11T18:50:49Z2020-05-11T18:50:49Z2007FREITAS, Silvia Regina Sampaio et al. Combined Analysis of Genetic and Environmental Factors on Essential Hypertension in a Brazilian Rural Population in the Amazon Region. Arquivos Brasileiros de Cardiologia, São Paulo, v. 88, n. 4, p. 393-397, 2007.0066-782Xhttps://www.arca.fiocruz.br/handle/icict/4118910.1590/s0066-782x20070004000141678-4170engSociedade Brasileira de CardiologiaPolimorfismosHipertensão essencialRisco ambientalGenéticaPolymorphismsEssential hypertensionEnvironmental riskGeneticCombined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon regioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.UNIGRANRIO. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Objective: In the present study, we evaluated the contribution of six genetic polymorphisms of the Renin-AngiotensisAldosterone system (RAAS) and clinical risk factors in the development of essential hypertension in a Brazilian rural population in the Amazon region. Methods: Eighty-two hypertensive patients and seventy-eight normotensive individuals were evaluated. Genotyping for renin (REN G1051A), angiotensinogen (AGT) M235T, insertion/deletion of angiotensin-converting enzyme (ACE I/D), angiotensin II type 1 receptor (AGTR1) A1166C and aldosterone synthase (CYP11B2) C344T polymorphisms were performed using polymerase chain reaction, with further restriction analysis when required. The influence of genetic polymorphisms and clinical risk factors on blood pressure variation was assessed by stepwise linear regression. Results: We report the co-occurrence of clinical risk factors and angiotensin-converting enzyme (ACE) gene polymorphism in a Brazilian rural population in the Amazon region. Our results indicate that increase of systolic blood pressure (SBP) is favored by ACE I/D- D allele and advanced age, while alcohol consumption and aging are associated with high diastolic blood pressure (DBP). Conclusion: These findings suggest that in the Santa Isabel do Rio Negro population, the residents that carry ACE-D allele or have an alcohol consumption habit present higher values of SBP and DBP, respectively, with the passing of years.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41189/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarcioNeves_Boia_etal_IOC_2007.pdfMarcioNeves_Boia_etal_IOC_2007.pdfapplication/pdf223005https://www.arca.fiocruz.br/bitstream/icict/41189/2/MarcioNeves_Boia_etal_IOC_2007.pdfdfa13c28f62d25613e0ffe84449f0af8MD52TEXTMarcioNeves_Boia_etal_IOC_2007.pdf.txtMarcioNeves_Boia_etal_IOC_2007.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region
title Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region
spellingShingle Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region
Freitas, Silvia Regina Sampaio
Polimorfismos
Hipertensão essencial
Risco ambiental
Genética
Polymorphisms
Essential hypertension
Environmental risk
Genetic
title_short Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region
title_full Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region
title_fullStr Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region
title_full_unstemmed Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region
title_sort Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region
author Freitas, Silvia Regina Sampaio
author_facet Freitas, Silvia Regina Sampaio
Cabello, Pedro Hernan
Moura Neto, Rodrigo Soares
Dolinsky, Luciana Cresta
Bóia, Márcio Neves
author_role author
author2 Cabello, Pedro Hernan
Moura Neto, Rodrigo Soares
Dolinsky, Luciana Cresta
Bóia, Márcio Neves
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Silvia Regina Sampaio
Cabello, Pedro Hernan
Moura Neto, Rodrigo Soares
Dolinsky, Luciana Cresta
Bóia, Márcio Neves
dc.subject.other.pt_BR.fl_str_mv Polimorfismos
Hipertensão essencial
Risco ambiental
Genética
topic Polimorfismos
Hipertensão essencial
Risco ambiental
Genética
Polymorphisms
Essential hypertension
Environmental risk
Genetic
dc.subject.en.pt_BR.fl_str_mv Polymorphisms
Essential hypertension
Environmental risk
Genetic
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2020-05-11T18:50:49Z
dc.date.available.fl_str_mv 2020-05-11T18:50:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREITAS, Silvia Regina Sampaio et al. Combined Analysis of Genetic and Environmental Factors on Essential Hypertension in a Brazilian Rural Population in the Amazon Region. Arquivos Brasileiros de Cardiologia, São Paulo, v. 88, n. 4, p. 393-397, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41189
dc.identifier.issn.pt_BR.fl_str_mv 0066-782X
dc.identifier.doi.none.fl_str_mv 10.1590/s0066-782x2007000400014
dc.identifier.eissn.none.fl_str_mv 1678-4170
identifier_str_mv FREITAS, Silvia Regina Sampaio et al. Combined Analysis of Genetic and Environmental Factors on Essential Hypertension in a Brazilian Rural Population in the Amazon Region. Arquivos Brasileiros de Cardiologia, São Paulo, v. 88, n. 4, p. 393-397, 2007.
0066-782X
10.1590/s0066-782x2007000400014
1678-4170
url https://www.arca.fiocruz.br/handle/icict/41189
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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