Epitranscriptome machinery in Trypanosomatids: New players on the table?

Detalhes bibliográficos
Autor(a) principal: Maran, Suellen Rodrigues
Data de Publicação: 2021
Outros Autores: Pitta, João Luiz de Lemos Padilha, Vasconcelos, Crhisllane Rafaele Dos Santos, McDermott, Suzanne M, Rezende, Antonio Mauro, Moretti, Nilmar Silvio
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58292
Resumo: Fundação Oswaldo Cruz. Department of Microbiology, Aggeu Magalhães Institute, Recife, PE, Brazil. Laboratory of Molecular Biology of Pathogens, Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, SP, Brazil. Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
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spelling Maran, Suellen RodriguesPitta, João Luiz de Lemos PadilhaVasconcelos, Crhisllane Rafaele Dos SantosMcDermott, Suzanne MRezende, Antonio MauroMoretti, Nilmar Silvio2023-05-10T16:15:28Z2023-05-10T16:15:28Z2021MARAN, Suellen Rodrigues et al. Epitranscriptome machinery in Trypanosomatids:: new players on the table?. Wiley. [S.L.], p. 942-958. 15 nov. 2020.1365-2958https://www.arca.fiocruz.br/handle/icict/5829210.1111/mmi.146881365-2958porEpitranscriptome machinery in Trypanosomatids: New players on the table?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Department of Microbiology, Aggeu Magalhães Institute, Recife, PE, Brazil. Laboratory of Molecular Biology of Pathogens, Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, SP, Brazil. Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.Trypanosoma and Leishmania parasites cause devastating tropical diseases resulting in serious global health consequences. These organisms have complex life cycles with mammalian hosts and insect vectors. The parasites must, therefore, survive in different environments, demanding rapid physiological and metabolic changes. These responses depend upon regulation of gene expression, which primarily occurs posttranscriptionally. Altering the composition or conformation of RNA through nucleotide modifications is one posttranscriptional mechanism of regulating RNA fate and function, and modifications including N6-methyladenosine (m6A), N1-methyladenosine (m1A), N5-methylcytidine (m5C), N4-acetylcytidine (ac4C), and pseudouridine (Ψ), dynamically regulate RNA stability and translation in diverse organisms. Little is known about RNA modifications and their machinery in Trypanosomatids, but we hypothesize that they regulate parasite gene expression and are vital for survival. Here, we identified Trypanosomatid homologs for writers of m1A, m5C, ac4C, and Ψ and analyze their evolutionary relationships. We systematically review the evidence for their functions and assess their potential use as therapeutic targets. This work provides new insights into the roles of these proteins in Trypanosomatid parasite biology and treatment of the diseases they cause and illustrates that Trypanosomatids provide an excellent model system to study RNA modifications, their molecular, cellular, and biological consequences, and their regulation and interplay.RNA modificationTrypanosomatidsac4Cm1Am5Cpseudouridineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALEpitranscriptome machinery in Trypanosomatids New players on the table.pdfEpitranscriptome machinery in Trypanosomatids New players on the table.pdfapplication/pdf16436472https://www.arca.fiocruz.br/bitstream/icict/58292/2/Epitranscriptome%20machinery%20in%20Trypanosomatids%20New%20players%20on%20the%20table.pdf4c1f876b5bb7c10ff86e0bb149ad88b5MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58292/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/582922023-05-16 12:23:23.617oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-16T15:23:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Epitranscriptome machinery in Trypanosomatids: New players on the table?
title Epitranscriptome machinery in Trypanosomatids: New players on the table?
spellingShingle Epitranscriptome machinery in Trypanosomatids: New players on the table?
Maran, Suellen Rodrigues
RNA modification
Trypanosomatids
ac4C
m1A
m5C
pseudouridine
title_short Epitranscriptome machinery in Trypanosomatids: New players on the table?
title_full Epitranscriptome machinery in Trypanosomatids: New players on the table?
title_fullStr Epitranscriptome machinery in Trypanosomatids: New players on the table?
title_full_unstemmed Epitranscriptome machinery in Trypanosomatids: New players on the table?
title_sort Epitranscriptome machinery in Trypanosomatids: New players on the table?
author Maran, Suellen Rodrigues
author_facet Maran, Suellen Rodrigues
Pitta, João Luiz de Lemos Padilha
Vasconcelos, Crhisllane Rafaele Dos Santos
McDermott, Suzanne M
Rezende, Antonio Mauro
Moretti, Nilmar Silvio
author_role author
author2 Pitta, João Luiz de Lemos Padilha
Vasconcelos, Crhisllane Rafaele Dos Santos
McDermott, Suzanne M
Rezende, Antonio Mauro
Moretti, Nilmar Silvio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Maran, Suellen Rodrigues
Pitta, João Luiz de Lemos Padilha
Vasconcelos, Crhisllane Rafaele Dos Santos
McDermott, Suzanne M
Rezende, Antonio Mauro
Moretti, Nilmar Silvio
dc.subject.en.en_US.fl_str_mv RNA modification
Trypanosomatids
ac4C
m1A
m5C
pseudouridine
topic RNA modification
Trypanosomatids
ac4C
m1A
m5C
pseudouridine
description Fundação Oswaldo Cruz. Department of Microbiology, Aggeu Magalhães Institute, Recife, PE, Brazil. Laboratory of Molecular Biology of Pathogens, Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, SP, Brazil. Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2023-05-10T16:15:28Z
dc.date.available.fl_str_mv 2023-05-10T16:15:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARAN, Suellen Rodrigues et al. Epitranscriptome machinery in Trypanosomatids:: new players on the table?. Wiley. [S.L.], p. 942-958. 15 nov. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58292
dc.identifier.issn.en_US.fl_str_mv 1365-2958
dc.identifier.doi.none.fl_str_mv 10.1111/mmi.14688
dc.identifier.eissn.none.fl_str_mv 1365-2958
identifier_str_mv MARAN, Suellen Rodrigues et al. Epitranscriptome machinery in Trypanosomatids:: new players on the table?. Wiley. [S.L.], p. 942-958. 15 nov. 2020.
1365-2958
10.1111/mmi.14688
url https://www.arca.fiocruz.br/handle/icict/58292
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58292/2/Epitranscriptome%20machinery%20in%20Trypanosomatids%20New%20players%20on%20the%20table.pdf
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