The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review

Detalhes bibliográficos
Autor(a) principal: Basso, Luiz Augusto
Data de Publicação: 2005
Outros Autores: Silva, Luiz Hildebrando Pereira da, Fett Neto, Arthur Germano, Azevedo Junior, Walter Filgueira de, Moreira, Ícaro de Souza, Palma, Mário Sérgio, Calixto, João Batista, Astolfi Filho, Spartaco, Santos, Ricardo Ribeiro dos, Soares, Milena Botelho Pereira, Santos, Diógenes Santiago
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6212
Resumo: Pontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Farmácia. Centro de Pesquisas em Biologia Molecular e Funcional. Porto Alegre, RS, Brasil
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spelling Basso, Luiz AugustoSilva, Luiz Hildebrando Pereira daFett Neto, Arthur GermanoAzevedo Junior, Walter Filgueira deMoreira, Ícaro de SouzaPalma, Mário SérgioCalixto, João BatistaAstolfi Filho, SpartacoSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraSantos, Diógenes Santiago2013-01-17T20:16:02Z2013-01-17T20:16:02Z2005BASSO, L. A. et al. The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review. Memórias do Instituto Oswaldo Cruz, v. 100, n. 6, p. 475-506, oct. 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/6212engThe use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Farmácia. Centro de Pesquisas em Biologia Molecular e Funcional. Porto Alegre, RS, BrasilCentro de Pesquisas em Medicina Tropical. Porto Velho, RO, BrasilUniversidade Federal do Rio Grande do Sul. Centro de Biotecnologia. Laboratório de Fisiologia Vegetal. Porto Alegre, RS, BrasilPontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Farmácia. Centro de Pesquisas em Biologia Molecular e Funcional. Porto Alegre, RS, Brasil.Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica. Fortaleza, CE, Brasil.Universidade do Estado de São Paulo. Laboratório de Biologia Estrutural e Zooquímica. Rio Claro, SP, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil.Universidade do Amazonas. Programa de Pós-Graduação em Biotecnologia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Pontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Farmácia. Centro de Pesquisas em Biologia Molecular e Funcional. Porto Alegre, RS, Brasil.The modern approach to the development of new chemical entities against complex diseases, especially theneglected endemic diseases such as tuberculosis and malaria, is based on the use of defined molecular targets.Among the advantages, this approach allows (i) the search and identification of lead compounds with definedmolecular mechanisms against a defined target (e.g. enzymes from defined pathways), (ii) the analysis of a greatnumber of compounds with a favorable cost/benefit ratio, (iii) the development even in the initial stages of com-pounds with selective toxicity (the fundamental principle of chemotherapy), (iv) the evaluation of plant extracts aswell as of pure substances. The current use of such technology, unfortunately, is concentrated in developed coun-tries, especially in the big pharma. This fact contributes in a significant way to hamper the development of innova-tive new compounds to treat neglected diseases. The large biodiversity within the territory of Brazil puts the countryin a strategic position to develop the rational and sustained exploration of new metabolites of therapeutic value.The extension of the country covers a wide range of climates, soil types, and altitudes, providing a unique set ofselective pressures for the adaptation of plant life in these scenarios. Chemical diversity is also driven by theseforces, in an attempt to best fit the plant communities to the particular abiotic stresses, fauna, and microbes that co-exist with them. Certain areas of vegetation (Amazonian Forest, Atlantic Forest, Araucaria Forest, Cerrado-Brazil-ian Savanna, and Caatinga) are rich in species and types of environments to be used to search for natural com-pounds active against tuberculosis, malaria, and chronic-degenerative diseases. The present review describes somestrategies to search for natural compounds, whose choice can be based on ethnobotanical and chemotaxonomicalstudies, and screen for their ability to bind to immobilized drug targets and to inhibit their activities. Molecularcloning, gene knockout, protein expression and purification, N-terminal sequencing, and mass spectrometry are themethods of choice to provide homogeneous drug targets for immobilization by optimized chemical reactions. Plantextract preparations, fractionation of promising plant extracts, propagation protocols and definition of in plantastudies to maximize product yield of plant species producing active compounds have to be performed to provide acontinuing supply of bioactive materials. Chemical characterization of natural compounds, determination of modeof action by kinetics and other spectroscopic methods (MS, X-ray, NMR), as well as in vitro and in vivo biologicalassays, chemical derivatization, and structure-activity relationships have to be carried out to provide a thoroughknowledge on which to base the search for natural compounds or their derivatives with biological activity.BiodiversityDefined molecular targetsTuberculosisApicomplexanT-cell mediated diseasesBiodiversidadePlantas Medicinais/químicaMarcação de Genes/métodosDesenho de DrogasPlantas Medicinais/genéticaMalária/quimioterapiaTuberculose Pulmonar/quimioterapiaLinfócitos TAntibacterianosAntimaláricosBrasilResearch Support, Non-U.S. Gov'tHumanosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBasso, Luiz Augusto et al. The use of biodversity....pdfBasso, Luiz Augusto et al. 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dc.title.pt_BR.fl_str_mv The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
title The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
spellingShingle The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
Basso, Luiz Augusto
Biodiversity
Defined molecular targets
Tuberculosis
Apicomplexan
T-cell mediated diseases
Biodiversidade
Plantas Medicinais/química
Marcação de Genes/métodos
Desenho de Drogas
Plantas Medicinais/genética
Malária/quimioterapia
Tuberculose Pulmonar/quimioterapia
Linfócitos T
Antibacterianos
Antimaláricos
Brasil
Research Support, Non-U.S. Gov't
Humanos
title_short The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
title_full The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
title_fullStr The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
title_full_unstemmed The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
title_sort The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
author Basso, Luiz Augusto
author_facet Basso, Luiz Augusto
Silva, Luiz Hildebrando Pereira da
Fett Neto, Arthur Germano
Azevedo Junior, Walter Filgueira de
Moreira, Ícaro de Souza
Palma, Mário Sérgio
Calixto, João Batista
Astolfi Filho, Spartaco
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Santos, Diógenes Santiago
author_role author
author2 Silva, Luiz Hildebrando Pereira da
Fett Neto, Arthur Germano
Azevedo Junior, Walter Filgueira de
Moreira, Ícaro de Souza
Palma, Mário Sérgio
Calixto, João Batista
Astolfi Filho, Spartaco
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Santos, Diógenes Santiago
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Basso, Luiz Augusto
Silva, Luiz Hildebrando Pereira da
Fett Neto, Arthur Germano
Azevedo Junior, Walter Filgueira de
Moreira, Ícaro de Souza
Palma, Mário Sérgio
Calixto, João Batista
Astolfi Filho, Spartaco
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Santos, Diógenes Santiago
dc.subject.en.pt_BR.fl_str_mv Biodiversity
Defined molecular targets
Tuberculosis
Apicomplexan
T-cell mediated diseases
topic Biodiversity
Defined molecular targets
Tuberculosis
Apicomplexan
T-cell mediated diseases
Biodiversidade
Plantas Medicinais/química
Marcação de Genes/métodos
Desenho de Drogas
Plantas Medicinais/genética
Malária/quimioterapia
Tuberculose Pulmonar/quimioterapia
Linfócitos T
Antibacterianos
Antimaláricos
Brasil
Research Support, Non-U.S. Gov't
Humanos
dc.subject.decs.pt_BR.fl_str_mv Biodiversidade
Plantas Medicinais/química
Marcação de Genes/métodos
Desenho de Drogas
Plantas Medicinais/genética
Malária/quimioterapia
Tuberculose Pulmonar/quimioterapia
Linfócitos T
Antibacterianos
Antimaláricos
Brasil
Research Support, Non-U.S. Gov't
Humanos
description Pontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Farmácia. Centro de Pesquisas em Biologia Molecular e Funcional. Porto Alegre, RS, Brasil
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2013-01-17T20:16:02Z
dc.date.available.fl_str_mv 2013-01-17T20:16:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BASSO, L. A. et al. The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review. Memórias do Instituto Oswaldo Cruz, v. 100, n. 6, p. 475-506, oct. 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6212
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv BASSO, L. A. et al. The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review. Memórias do Instituto Oswaldo Cruz, v. 100, n. 6, p. 475-506, oct. 2005.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/6212
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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instacron_str FIOCRUZ
institution FIOCRUZ
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