Identification of 170 new long noncoding RNAs in Schistosoma mansoni
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32943 |
Resumo: | Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Ciências Biológicas. Ouro Preto, MG, Brasil. |
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Oliveira, Victor Fernandes deMoraes, Lauro Ângelo Gonçalves deMota, Ester AlvesPassos, Liana Konovaloff JannottiCoelho, Paulo Marcos ZechMattos, Ana Carolina Alves deCouto, Flávia Fernanda BúbulaCaffrey, Brian E.Marsico, AnnalisaCota, Renata Guerra de Sá2019-05-06T13:31:20Z2019-05-06T13:31:20Z2018OLIVEIRA, Victor Fernandes de et al. Identification of 170 new long noncoding RNAs in Schistosoma mansoni. BioMed Research International, v. 2018, p. 1-10, 2018.2314- 6141https://www.arca.fiocruz.br/handle/icict/3294310.1155/2018/1264697engBioMed CentralSchistosoma mansoniProgressão de câncerSchistosoma mansoniCancer progressionIdentification of 170 new long noncoding RNAs in Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Ciências Biológicas. Ouro Preto, MG, Brasil.Universidade Federal de Ouro Preto. Laboratório de Computação de Sistemas Inteligentes. Departamento de Computação. Ouro Preto, MG, Brasil.Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Ciências Biológicas. Ouro Preto, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil.Max Planck Institute for Molecular Genetics. IBerlin, Germany.Max Planck Institute for Molecular Genetics. IBerlin, Germany / Freie Universitaet Berlin. Berlin, Germany.Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Ciências Biológicas. Ouro Preto, MG, Brasil.Long noncoding RNAs (lncRNAs) are transcripts generally longer than 200 nucleotides with no or poor protein coding potential, and most of their functions are also poorly characterized. Recently, an increasing number of studies have shown that lncRNAs can be involved in various critical biological processes such as organism development or cancer progression. Little, however, is known about their effects in helminths parasites, such as Schistosoma mansoni. Here, we present a computational pipeline to identify and characterize lncRNAs from RNA-seq data with high confidence from S. mansoni adult worms. Through the utilization of different criteria such as genome localization, exon number, gene length, and stability, we identified 170 new putative lncRNAs. All novel S. mansoni lncRNAs have no conserved synteny including human and mouse. These closest protein coding genes were enriched in 10 significant Gene Ontology terms related to metabolism, transport, and biosynthesis. Fifteen putative lncRNAs showed differential expression, and three displayed sex-specific differential expressions in praziquantel sensitive and resistant adult worm couples. Together, our method can predict a set of novel lncRNAs from the RNA-seq data. Some lncRNAs are shown to be differentially expressed suggesting that those novel lncRNAs can be given high priority in further functional studies focused on praziquantel resistance.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/32943/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIdentification of 170 .pdfIdentification of 170 .pdfapplication/pdf5245630https://www.arca.fiocruz.br/bitstream/icict/32943/2/Identification%20of%20170%20.pdf31b67e6b5afdb68bbfba7d3b3caf5550MD52TEXTIdentification of 170 .pdf.txtIdentification of 170 .pdf.txtExtracted texttext/plain3054https://www.arca.fiocruz.br/bitstream/icict/32943/3/Identification%20of%20170%20.pdf.txtfad5ad0e429dabd4e29a26b48f19bae0MD53icict/329432019-05-08 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| dc.title.pt_BR.fl_str_mv |
Identification of 170 new long noncoding RNAs in Schistosoma mansoni |
| title |
Identification of 170 new long noncoding RNAs in Schistosoma mansoni |
| spellingShingle |
Identification of 170 new long noncoding RNAs in Schistosoma mansoni Oliveira, Victor Fernandes de Schistosoma mansoni Progressão de câncer Schistosoma mansoni Cancer progression |
| title_short |
Identification of 170 new long noncoding RNAs in Schistosoma mansoni |
| title_full |
Identification of 170 new long noncoding RNAs in Schistosoma mansoni |
| title_fullStr |
Identification of 170 new long noncoding RNAs in Schistosoma mansoni |
| title_full_unstemmed |
Identification of 170 new long noncoding RNAs in Schistosoma mansoni |
| title_sort |
Identification of 170 new long noncoding RNAs in Schistosoma mansoni |
| author |
Oliveira, Victor Fernandes de |
| author_facet |
Oliveira, Victor Fernandes de Moraes, Lauro Ângelo Gonçalves de Mota, Ester Alves Passos, Liana Konovaloff Jannotti Coelho, Paulo Marcos Zech Mattos, Ana Carolina Alves de Couto, Flávia Fernanda Búbula Caffrey, Brian E. Marsico, Annalisa Cota, Renata Guerra de Sá |
| author_role |
author |
| author2 |
Moraes, Lauro Ângelo Gonçalves de Mota, Ester Alves Passos, Liana Konovaloff Jannotti Coelho, Paulo Marcos Zech Mattos, Ana Carolina Alves de Couto, Flávia Fernanda Búbula Caffrey, Brian E. Marsico, Annalisa Cota, Renata Guerra de Sá |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Victor Fernandes de Moraes, Lauro Ângelo Gonçalves de Mota, Ester Alves Passos, Liana Konovaloff Jannotti Coelho, Paulo Marcos Zech Mattos, Ana Carolina Alves de Couto, Flávia Fernanda Búbula Caffrey, Brian E. Marsico, Annalisa Cota, Renata Guerra de Sá |
| dc.subject.other.pt_BR.fl_str_mv |
Schistosoma mansoni Progressão de câncer |
| topic |
Schistosoma mansoni Progressão de câncer Schistosoma mansoni Cancer progression |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni Cancer progression |
| description |
Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Ciências Biológicas. Ouro Preto, MG, Brasil. |
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2018 |
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2018 |
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2019-05-06T13:31:20Z |
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2019-05-06T13:31:20Z |
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OLIVEIRA, Victor Fernandes de et al. Identification of 170 new long noncoding RNAs in Schistosoma mansoni. BioMed Research International, v. 2018, p. 1-10, 2018. |
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https://www.arca.fiocruz.br/handle/icict/32943 |
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2314- 6141 |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2018/1264697 |
| identifier_str_mv |
OLIVEIRA, Victor Fernandes de et al. Identification of 170 new long noncoding RNAs in Schistosoma mansoni. BioMed Research International, v. 2018, p. 1-10, 2018. 2314- 6141 10.1155/2018/1264697 |
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