Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study

Detalhes bibliográficos
Autor(a) principal: Orioli, Iêda M.
Data de Publicação: 2017
Outros Autores: Dolk, Helen, López-Camelo, Jorge S., Mattos, Daniel, Poletta, Fernando A., Dutra, Maria G., Carvalho, Flavia M., Castilla, Eduardo E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23534
Resumo: Universidade Federal do Rio de Janeiro, Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Estudo colaborativo latino-americano de malformações congênitas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Genética Médica Populacional. Porto Alegre, RS, Brasil.
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spelling Orioli, Iêda M.Dolk, HelenLópez-Camelo, Jorge S.Mattos, DanielPoletta, Fernando A.Dutra, Maria G.Carvalho, Flavia M.Castilla, Eduardo E.2017-12-07T10:25:41Z2017-12-07T10:25:41Z2017ORIOLI, Iêda M. et al. Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study. BMJ, v.359:j5018, 11p, 2017.1756-1833https://www.arca.fiocruz.br/handle/icict/2353410.1136/bmj.j5018engBMJ Publishing GroupZika VirusMicrocefaliaAmérica do SulPrevalênciaEstudo de casoZika VirusmicrocephalySouth Americaprevalencecase-control studyPrevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro, Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Estudo colaborativo latino-americano de malformações congênitas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Genética Médica Populacional. Porto Alegre, RS, Brasil.Ulster University. Institute of Nursing and Health Research. Maternal Fetal and Infant Research Centre. Newtownabbey, Northern Ireland, UK.Instituto Nacional de Genética Médica Populacional. Porto Alegre, RS, Brasil / ECLAMC at Center for Medical Education and Clinical Research (CEMIC-CONICET). Buenos Aires, Argentina.Universidade Federal do Rio de Janeiro, Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Estudo colaborativo latino-americano de malformações congênitas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Genética Médica Populacional. Porto Alegre, RS, Brasil.Instituto Nacional de Genética Médica Populacional. Porto Alegre, RS, Brasil / ECLAMC at Center for Medical Education and Clinical Research (CEMIC-CONICET). Buenos Aires, Argentina.Instituto Nacional de Genética Médica Populacional. Porto Alegre, RS, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. Estudo Colaborativo Latino-americano de Malformações Congênitas. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Genética Médica Populacional. Porto Alegre, RS, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. Estudo Colaborativo Latino-americano de Malformações Congênitas. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Genética Médica Populacional. Porto Alegre, RS, Brasil / ECLAMC at Center for Medical Education and Clinical Research (CEMIC-CONICET). Buenos Aires, Argentina.Objective To describe the prevalence and clinical spectrum of microcephaly in South America for the period 2005-14, before the start of the Zika epidemic in 2015, as a baseline for future surveillance as the Zika epidemic spreads and as other infectious causes may emerge in future.Design Prevalence and case-control study.Data sources ECLAMC (Latin American Collaborative Study of Congenital Malformations) database derived from 107 hospitals in 10 South American countries, 2005 to 2014. Data on microcephaly cases, four non-malformed controls per case, and all hospital births (all births for hospital based prevalence, resident within municipality for population based prevalence). For 2010-14, head circumference data were available and compared with Intergrowth charts.Results 552 microcephaly cases were registered, giving a hospital based prevalence of 4.4 (95% confidence interval 4.1 to 4.9) per 10 000 births and a population based prevalence of 3.0 (2.7 to 3.4) per 10 000. Prevalence varied significantly between countries and between regions and hospitals within countries. Thirty two per cent (n=175) of cases were prenatally diagnosed; 29% (n=159) were perinatal deaths. Twenty three per cent (n=128) were associated with a diagnosed genetic syndrome, 34% (n=189) polymalformed without a syndrome diagnosis, 12% (n=65) with associated neural malformations, and 26% (n=145) microcephaly only. In addition, 3.8% (n=21) had a STORCH (syphilis, toxoplasmosis, other including HIV, rubella, cytomegalovirus, and herpes simplex) infection diagnosis and 2.0% (n=11) had consanguineous parents. Head circumference measurements available for 184/235 cases in 2010-14 showed 45% (n=82) more than 3 SD below the mean, 24% (n=44) between 3 SD and 2 SD below the mean, and 32% (n=58) larger than -2 SD.Conclusion Extrapolated to the nearly 7 million annual births in South America, an estimated 2000-2500 microcephaly cases were diagnosed among births each year before the Zika epidemic began in 2015. Clinicians are using more than simple metrics to make microcephaly diagnoses. 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dc.title.pt_BR.fl_str_mv Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study
title Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study
spellingShingle Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study
Orioli, Iêda M.
Zika Virus
Microcefalia
América do Sul
Prevalência
Estudo de caso
Zika Virus
microcephaly
South America
prevalence
case-control study
title_short Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study
title_full Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study
title_fullStr Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study
title_full_unstemmed Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study
title_sort Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study
author Orioli, Iêda M.
author_facet Orioli, Iêda M.
Dolk, Helen
López-Camelo, Jorge S.
Mattos, Daniel
Poletta, Fernando A.
Dutra, Maria G.
Carvalho, Flavia M.
Castilla, Eduardo E.
author_role author
author2 Dolk, Helen
López-Camelo, Jorge S.
Mattos, Daniel
Poletta, Fernando A.
Dutra, Maria G.
Carvalho, Flavia M.
Castilla, Eduardo E.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Orioli, Iêda M.
Dolk, Helen
López-Camelo, Jorge S.
Mattos, Daniel
Poletta, Fernando A.
Dutra, Maria G.
Carvalho, Flavia M.
Castilla, Eduardo E.
dc.subject.other.pt_BR.fl_str_mv Zika Virus
Microcefalia
América do Sul
Prevalência
Estudo de caso
topic Zika Virus
Microcefalia
América do Sul
Prevalência
Estudo de caso
Zika Virus
microcephaly
South America
prevalence
case-control study
dc.subject.en.pt_BR.fl_str_mv Zika Virus
microcephaly
South America
prevalence
case-control study
description Universidade Federal do Rio de Janeiro, Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Estudo colaborativo latino-americano de malformações congênitas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Genética Médica Populacional. Porto Alegre, RS, Brasil.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-12-07T10:25:41Z
dc.date.available.fl_str_mv 2017-12-07T10:25:41Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ORIOLI, Iêda M. et al. Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study. BMJ, v.359:j5018, 11p, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23534
dc.identifier.issn.pt_BR.fl_str_mv 1756-1833
dc.identifier.doi.none.fl_str_mv 10.1136/bmj.j5018
identifier_str_mv ORIOLI, Iêda M. et al. Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study. BMJ, v.359:j5018, 11p, 2017.
1756-1833
10.1136/bmj.j5018
url https://www.arca.fiocruz.br/handle/icict/23534
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
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