Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations

Kehdy, Fernanda de Souza Gomes; Gouveia, Mateus Henrique; Machado, Moara; Magalhães, Wagner Carlos Santos; Horimoto, Andrea Roseli Vançan Russo; Horta, Bernardo Lessa; Moreira, Rennan Garcias; Leal, Thiago P.; Scliar, Marilia de Oliveira; Souza, Giordano Bruno Soares; Soares, Fernanda Rodrigues; Araújo, Gilderlanio Santana de; Zamudio, Roxana; Sant Anna, Hanaisa de Pla e; Santos, Hadassa Cristhina de Azevedo Soares dos; Duarte, Nubia Esteban; Fiaccone, Rosemeire Leovigildo; Figueiredo, Camila A.; Silva, Thiago Magalhães de; Costa, Gustavo Nunes de Oliveira; Beleza, Sandra; Berg, Douglas E.; Cabrera, Lilia; Duarte, Denise; Ghirotto, Silvia; Gilman, Robert H; Gonçalves, Vanessa F.; Marrero, Andrea Rita; Muniz, Yara C.; Weissensteiner, Hansi; Yeager, Meredith; Rodrigues, Laura C.; Barreto, Mauricio Lima; Costa, Maria Fernanda Lima; Pereira, Alexandre da Costa; Rodrigues, Maíra Ribeiro; Santos, Eduardo Martín Tarazona; Neves, Neuza Alcantara; Araújo, Nathalia M.; Carvalho, Márcio L.B.; Conceição, Jackson Santos; Firmo, Josélia Oliveira Araújo; Gigante, Denise Petrucci; Meira, Lindolfo; Queiroz, Thais Muniz; Oliveira, Guilherme Correa de; Oliveira, Isabel O.; Peixoto, Sérgio William Viana; Proietti, Fernando Augusto; Rodrigues, Domingos C.; Santolalla, Meddly L.; Strina, Agostino; Zolini, Camila

Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations

Detalhes bibliográficos
Autor(a) principal:	Kehdy, Fernanda de Souza Gomes
Data de Publicação:	2015
Outros Autores:	Gouveia, Mateus Henrique, Machado, Moara, Magalhães, Wagner Carlos Santos, Horimoto, Andrea Roseli Vançan Russo, Horta, Bernardo Lessa, Moreira, Rennan Garcias, Leal, Thiago P., Scliar, Marilia de Oliveira, Souza, Giordano Bruno Soares, Soares, Fernanda Rodrigues, Araújo, Gilderlanio Santana de, Zamudio, Roxana, Sant Anna, Hanaisa de Pla e, Santos, Hadassa Cristhina de Azevedo Soares dos, Duarte, Nubia Esteban, Fiaccone, Rosemeire Leovigildo, Figueiredo, Camila A., Silva, Thiago Magalhães de, Costa, Gustavo Nunes de Oliveira, Beleza, Sandra, Berg, Douglas E., Cabrera, Lilia, Duarte, Denise, Ghirotto, Silvia, Gilman, Robert H, Gonçalves, Vanessa F., Marrero, Andrea Rita, Muniz, Yara C., Weissensteiner, Hansi, Yeager, Meredith, Rodrigues, Laura C., Barreto, Mauricio Lima, Costa, Maria Fernanda Lima, Pereira, Alexandre da Costa, Rodrigues, Maíra Ribeiro, Santos, Eduardo Martín Tarazona, Neves, Neuza Alcantara, Araújo, Nathalia M., Carvalho, Márcio L.B., Conceição, Jackson Santos, Firmo, Josélia Oliveira Araújo, Gigante, Denise Petrucci, Meira, Lindolfo, Queiroz, Thais Muniz, Oliveira, Guilherme Correa de, Oliveira, Isabel O., Peixoto, Sérgio William Viana, Proietti, Fernando Augusto, Rodrigues, Domingos C., Santolalla, Meddly L., Strina, Agostino, Zolini, Camila
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/12757
Resumo:	Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
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spelling	Kehdy, Fernanda de Souza GomesGouveia, Mateus HenriqueMachado, MoaraMagalhães, Wagner Carlos SantosHorimoto, Andrea Roseli Vançan RussoHorta, Bernardo LessaMoreira, Rennan GarciasLeal, Thiago P.Scliar, Marilia de OliveiraSouza, Giordano Bruno SoaresSoares, Fernanda RodriguesAraújo, Gilderlanio Santana deZamudio, RoxanaSant Anna, Hanaisa de Pla eSantos, Hadassa Cristhina de Azevedo Soares dosDuarte, Nubia EstebanFiaccone, Rosemeire LeovigildoFigueiredo, Camila A.Silva, Thiago Magalhães deCosta, Gustavo Nunes de OliveiraBeleza, SandraBerg, Douglas E.Cabrera, LiliaDuarte, DeniseGhirotto, SilviaGilman, Robert HGonçalves, Vanessa F.Marrero, Andrea RitaMuniz, Yara C.Weissensteiner, HansiYeager, MeredithRodrigues, Laura C.Barreto, Mauricio LimaCosta, Maria Fernanda LimaPereira, Alexandre da CostaRodrigues, Maíra RibeiroSantos, Eduardo Martín TarazonaNeves, Neuza AlcantaraAraújo, Nathalia M.Carvalho, Márcio L.B.Conceição, Jackson SantosFirmo, Josélia Oliveira AraújoGigante, Denise PetrucciMeira, LindolfoQueiroz, Thais MunizOliveira, Guilherme Correa deOliveira, Isabel O.Peixoto, Sérgio William VianaProietti, Fernando AugustoRodrigues, Domingos C.Santolalla, Meddly L.Strina, AgostinoZolini, Camila2016-02-19T13:37:09Z2016-02-19T13:37:09Z2015KEHDY, Fernanda de Souza Gomes et al. Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8696–8701.0027-8424https://www.arca.fiocruz.br/handle/icict/1275710.1073/pnas.1504447112engNational Academy of SciencesOrigin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade de São Paulo. Instituto do Coração. São Paulo, SP, BrasilUniversidade Federal de Pelotas. Programa de Pós-Graduação em Epidemiologia. Pelotas, RS, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade de São Paulo. Instituto do Coração. São Paulo, SP, BrasilUniversidade de São Paulo. Instituto do Coração. São Paulo, SP, BrasilUniversidade Federal da Bahia. Instituto de Matemática. Departamento de Estatística. Salvador, Bahia, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, Bahia, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversity of Leicester. Department of Genetics. Leicester, United KingdomWashington University School of Medicine. Department of Molecular Microbiology. St. Louis, MO/University of California. Department of Medicine. San Diego, CAAsociación Benéfica Proyectos en Informática, Salud, Medicina y Agricultura. Biomedical Research Unit. Lima, PeruUniversidade Federal de Santa Catarina. Embriologia e Genética. Departamento de Biologia Celular. Florianópolis, SC, BrasilUniversidade Federal de Minas Gerais. Departamento de Estatística. Belo Horizonte, MG, BrasilUniversità di Ferrara. Dipartimento di Scienze della Vita e Biotecnologie. Ferrara, ItalyJohns Hopkins University. International Health. Bloomberg School of Public Health. Baltimore, MD, USA/Universidade Peruana Cayetano Heredia. Laboratorio de Investigación de Enfermedades Infecciosas. Lima, PeruUniversity of Toronto. Center for Addiction and Mental Health. Department of Psychiatry and Neuroscience Section. Toronto, ON, CanadaUniversidade Federal de Santa Catarina. Embriologia e Genética. Departamento de Biologia Celular. Florianópolis, SC, BrasilUniversidade Federal de Santa Catarina. Embriologia e Genética. Departamento de Biologia Celular. Florianópolis, SC, BrasilInnsbruck Medical University. Molecular and Clinical Pharmacology. Department of Medical Genetics. Division of Genetic Epidemiology. Innsbruck, AustriaFrederick National Laboratory for Cancer Research. Leidos Biomedical Research. Cancer Genomics Research Laboratory. Frederick, MDLondon School of Hygiene and Tropical Medicine. Faculty of Epidemiology. Department of Infectious Disease Epidemiology. London, United KingdomUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto de Pesquisa Rene Rachou. Belo Horizonte, MG, BrasilUniversidade de São Paulo. Instituto do Coração. São Paulo, SP, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Laboratório de Computação Científica. Belo Horizonte, MG, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Pelotas. Programa de Pós-Graduação em Epidemiologia. Pelotas, RS, Brasil.Universidade Federal de Rio Grande do Sul. Centro Nacional de Supercomputação. Porto Alegre, RS, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Rene Rachou. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil.Universidade Federal de Pelotas. Programa de Pós-Graduação em Epidemiologia. Pelotas, RS, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Laboratório de Computação Científica. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil.While South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture.We present the results of the EPIGEN Brazil Initiative, the most comprehensive up-to-date genomic analysis of any Latin-American population. A population-based genomewide analysis of 6,487 individuals was performed in the context of worldwide genomic diversity to elucidate how ancestry, kinship, and inbreeding interact in three populations with different histories from the Northeast (African ancestry: 50%), Southeast, and South (both with European ancestry >70%) of Brazil. We showed that ancestry-positive assortative mating permeated Brazilian history. We traced European ancestry in the Southeast/South to a wider European/Middle Eastern region with respect to the Northeast, where ancestry seems restricted to Iberia. By developing an approximate Bayesian computation framework, we infer more recent European immigration to the Southeast/South than to the Northeast. Also, the observed low Native-American ancestry (6–8%) was mostly introduced in different regions of Brazil soon after the European Conquest. We broadened our understanding of the African diaspora, the major destination of which was Brazil, by revealing that Brazilians display two within-Africa ancestry components: one associated with non-Bantu/western Africans (more evident in the Northeast and African Americans) and one associated with Bantu/eastern Africans (more present in the Southeast/South). Furthermore, the whole-genome analysis of 30 individuals (42-fold deep coverage) shows that continental admixture rather than local post-Columbian history is the main and complex determinant of the individual amount of deleterious genotypes.Latin Americapopulation geneticsSalvador SCAALABambuí Cohort Study of AgeingPelotas Birth Cohort Studyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12757/1/license.txt5a560609d32a3863062d77ff32785d58MD51TEXTOrigin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations..pdf.txtOrigin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations..pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
title	Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
spellingShingle	Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations Kehdy, Fernanda de Souza Gomes Latin America population genetics Salvador SCAALA Bambuí Cohort Study of Ageing Pelotas Birth Cohort Study
title_short	Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
title_full	Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
title_fullStr	Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
title_full_unstemmed	Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
title_sort	Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
author	Kehdy, Fernanda de Souza Gomes
author_facet	Kehdy, Fernanda de Souza Gomes Gouveia, Mateus Henrique Machado, Moara Magalhães, Wagner Carlos Santos Horimoto, Andrea Roseli Vançan Russo Horta, Bernardo Lessa Moreira, Rennan Garcias Leal, Thiago P. Scliar, Marilia de Oliveira Souza, Giordano Bruno Soares Soares, Fernanda Rodrigues Araújo, Gilderlanio Santana de Zamudio, Roxana Sant Anna, Hanaisa de Pla e Santos, Hadassa Cristhina de Azevedo Soares dos Duarte, Nubia Esteban Fiaccone, Rosemeire Leovigildo Figueiredo, Camila A. Silva, Thiago Magalhães de Costa, Gustavo Nunes de Oliveira Beleza, Sandra Berg, Douglas E. Cabrera, Lilia Duarte, Denise Ghirotto, Silvia Gilman, Robert H Gonçalves, Vanessa F. Marrero, Andrea Rita Muniz, Yara C. Weissensteiner, Hansi Yeager, Meredith Rodrigues, Laura C. Barreto, Mauricio Lima Costa, Maria Fernanda Lima Pereira, Alexandre da Costa Rodrigues, Maíra Ribeiro Santos, Eduardo Martín Tarazona Neves, Neuza Alcantara Araújo, Nathalia M. Carvalho, Márcio L.B. Conceição, Jackson Santos Firmo, Josélia Oliveira Araújo Gigante, Denise Petrucci Meira, Lindolfo Queiroz, Thais Muniz Oliveira, Guilherme Correa de Oliveira, Isabel O. Peixoto, Sérgio William Viana Proietti, Fernando Augusto Rodrigues, Domingos C. Santolalla, Meddly L. Strina, Agostino Zolini, Camila
author_role	author
author2	Gouveia, Mateus Henrique Machado, Moara Magalhães, Wagner Carlos Santos Horimoto, Andrea Roseli Vançan Russo Horta, Bernardo Lessa Moreira, Rennan Garcias Leal, Thiago P. Scliar, Marilia de Oliveira Souza, Giordano Bruno Soares Soares, Fernanda Rodrigues Araújo, Gilderlanio Santana de Zamudio, Roxana Sant Anna, Hanaisa de Pla e Santos, Hadassa Cristhina de Azevedo Soares dos Duarte, Nubia Esteban Fiaccone, Rosemeire Leovigildo Figueiredo, Camila A. Silva, Thiago Magalhães de Costa, Gustavo Nunes de Oliveira Beleza, Sandra Berg, Douglas E. Cabrera, Lilia Duarte, Denise Ghirotto, Silvia Gilman, Robert H Gonçalves, Vanessa F. Marrero, Andrea Rita Muniz, Yara C. Weissensteiner, Hansi Yeager, Meredith Rodrigues, Laura C. Barreto, Mauricio Lima Costa, Maria Fernanda Lima Pereira, Alexandre da Costa Rodrigues, Maíra Ribeiro Santos, Eduardo Martín Tarazona Neves, Neuza Alcantara Araújo, Nathalia M. Carvalho, Márcio L.B. Conceição, Jackson Santos Firmo, Josélia Oliveira Araújo Gigante, Denise Petrucci Meira, Lindolfo Queiroz, Thais Muniz Oliveira, Guilherme Correa de Oliveira, Isabel O. Peixoto, Sérgio William Viana Proietti, Fernando Augusto Rodrigues, Domingos C. Santolalla, Meddly L. Strina, Agostino Zolini, Camila
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Kehdy, Fernanda de Souza Gomes Gouveia, Mateus Henrique Machado, Moara Magalhães, Wagner Carlos Santos Horimoto, Andrea Roseli Vançan Russo Horta, Bernardo Lessa Moreira, Rennan Garcias Leal, Thiago P. Scliar, Marilia de Oliveira Souza, Giordano Bruno Soares Soares, Fernanda Rodrigues Araújo, Gilderlanio Santana de Zamudio, Roxana Sant Anna, Hanaisa de Pla e Santos, Hadassa Cristhina de Azevedo Soares dos Duarte, Nubia Esteban Fiaccone, Rosemeire Leovigildo Figueiredo, Camila A. Silva, Thiago Magalhães de Costa, Gustavo Nunes de Oliveira Beleza, Sandra Berg, Douglas E. Cabrera, Lilia Duarte, Denise Ghirotto, Silvia Gilman, Robert H Gonçalves, Vanessa F. Marrero, Andrea Rita Muniz, Yara C. Weissensteiner, Hansi Yeager, Meredith Rodrigues, Laura C. Barreto, Mauricio Lima Costa, Maria Fernanda Lima Pereira, Alexandre da Costa Rodrigues, Maíra Ribeiro Santos, Eduardo Martín Tarazona Neves, Neuza Alcantara Araújo, Nathalia M. Carvalho, Márcio L.B. Conceição, Jackson Santos Firmo, Josélia Oliveira Araújo Gigante, Denise Petrucci Meira, Lindolfo Queiroz, Thais Muniz Oliveira, Guilherme Correa de Oliveira, Isabel O. Peixoto, Sérgio William Viana Proietti, Fernando Augusto Rodrigues, Domingos C. Santolalla, Meddly L. Strina, Agostino Zolini, Camila
dc.subject.en.pt_BR.fl_str_mv	Latin America population genetics Salvador SCAALA Bambuí Cohort Study of Ageing Pelotas Birth Cohort Study
topic	Latin America population genetics Salvador SCAALA Bambuí Cohort Study of Ageing Pelotas Birth Cohort Study
description	Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil
publishDate	2015
dc.date.issued.fl_str_mv	2015
dc.date.accessioned.fl_str_mv	2016-02-19T13:37:09Z
dc.date.available.fl_str_mv	2016-02-19T13:37:09Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	KEHDY, Fernanda de Souza Gomes et al. Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8696–8701.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/12757
dc.identifier.issn.none.fl_str_mv	0027-8424
dc.identifier.doi.none.fl_str_mv	10.1073/pnas.1504447112
identifier_str_mv	KEHDY, Fernanda de Souza Gomes et al. Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8696–8701. 0027-8424 10.1073/pnas.1504447112
url	https://www.arca.fiocruz.br/handle/icict/12757
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	National Academy of Sciences
publisher.none.fl_str_mv	National Academy of Sciences
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/12757/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/12757/3/Origin%20and%20dynamics%20of%20admixture%20in%20Brazilians%20and%20its%20effect%20on%20the%20pattern%20of%20deleterious%20mutations..pdf.txt https://www.arca.fiocruz.br/bitstream/icict/12757/5/8696.full.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/12757/4/8696.full.pdf
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations

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