Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives

Detalhes bibliográficos
Autor(a) principal: Bispo, Marcelle de Lima Ferreira
Data de Publicação: 2015
Outros Autores: Cardoso, Laura Nogueira de Faria, Lourenço, Maria Cristina da Silva, Bezerra, Flávio Augusto Ferreira Martins, Soares, Rodrigo Pedro Pinto, Bertollo, Caryne Margotto, Souza, Marcus Vinícius Nora de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51105
Resumo: CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
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spelling Bispo, Marcelle de Lima FerreiraCardoso, Laura Nogueira de FariaLourenço, Maria Cristina da SilvaBezerra, Flávio Augusto Ferreira MartinsSoares, Rodrigo Pedro PintoBertollo, Caryne MargottoSouza, Marcus Vinícius Nora de2022-02-09T13:29:07Z2022-02-09T13:29:07Z2015BISPO, Marcelle de Lima Ferreira et al. Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives. Mediterranean Journal of Chemistry, v. 4, n. 1, p. 1-8, 2015. DOI: http://dx.doi.org/10.13171/mjc.4.1.2015.19.02.10.18/desouza2028-3997https://www.arca.fiocruz.br/handle/icict/5110510.13171/mjc.4.1.2015.15.02.20/desouzaCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos-Far Manguinhos. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos-Far Manguinhos. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Departamento de Bacteriologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Departamento de Bacteriologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos-Far Manguinhos. Rio de Janeiro, RJ, Brazil.A series of eight 7-chloro-4-alkoxyquinoline derivatives (2a-h) have been synthesized and their in vitro (antimycobacterial) activity against Mycobacterium tuberculosis was evaluated. Furthermore, all the active compounds were selected for evaluation of their cytotoxicities against the human hepatoma (HepG2) and the relative selectivity (selective index) of these compounds against M. tuberculosis compared to HepG2 was calculated based on MLD50/MIC ratios. These biological results have been compared to a series of 7-chloro-4-aminoquinoline derivatives 1a-i, previously identified by our research group with the aim to provide important information about the structure-activity relationship of quinoline derivatives.engAbdelaziz SOUIZSynthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/51105/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINAL-Synthesis_and_antitubercular_evaluation_of_7-chlor.pdf-Synthesis_and_antitubercular_evaluation_of_7-chlor.pdfapplication/pdf412996https://www.arca.fiocruz.br/bitstream/icict/51105/2/-Synthesis_and_antitubercular_evaluation_of_7-chlor.pdfd8213e9886d3a0e5183f91fe8b9a96ceMD52icict/511052022-02-09 10:29:07.878oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-02-09T13:29:07Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives
title Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives
spellingShingle Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives
Bispo, Marcelle de Lima Ferreira
title_short Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives
title_full Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives
title_fullStr Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives
title_full_unstemmed Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives
title_sort Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives
author Bispo, Marcelle de Lima Ferreira
author_facet Bispo, Marcelle de Lima Ferreira
Cardoso, Laura Nogueira de Faria
Lourenço, Maria Cristina da Silva
Bezerra, Flávio Augusto Ferreira Martins
Soares, Rodrigo Pedro Pinto
Bertollo, Caryne Margotto
Souza, Marcus Vinícius Nora de
author_role author
author2 Cardoso, Laura Nogueira de Faria
Lourenço, Maria Cristina da Silva
Bezerra, Flávio Augusto Ferreira Martins
Soares, Rodrigo Pedro Pinto
Bertollo, Caryne Margotto
Souza, Marcus Vinícius Nora de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bispo, Marcelle de Lima Ferreira
Cardoso, Laura Nogueira de Faria
Lourenço, Maria Cristina da Silva
Bezerra, Flávio Augusto Ferreira Martins
Soares, Rodrigo Pedro Pinto
Bertollo, Caryne Margotto
Souza, Marcus Vinícius Nora de
description CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2022-02-09T13:29:07Z
dc.date.available.fl_str_mv 2022-02-09T13:29:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BISPO, Marcelle de Lima Ferreira et al. Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives. Mediterranean Journal of Chemistry, v. 4, n. 1, p. 1-8, 2015. DOI: http://dx.doi.org/10.13171/mjc.4.1.2015.19.02.10.18/desouza
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51105
dc.identifier.issn.pt_BR.fl_str_mv 2028-3997
dc.identifier.doi.none.fl_str_mv 10.13171/mjc.4.1.2015.15.02.20/desouza
identifier_str_mv BISPO, Marcelle de Lima Ferreira et al. Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives. Mediterranean Journal of Chemistry, v. 4, n. 1, p. 1-8, 2015. DOI: http://dx.doi.org/10.13171/mjc.4.1.2015.19.02.10.18/desouza
2028-3997
10.13171/mjc.4.1.2015.15.02.20/desouza
url https://www.arca.fiocruz.br/handle/icict/51105
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Abdelaziz SOUIZ
publisher.none.fl_str_mv Abdelaziz SOUIZ
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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