Phenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activation

Detalhes bibliográficos
Autor(a) principal: Silva, José R. Lapa e
Data de Publicação: 1996
Outros Autores: Linhares, Cristiane, Boechat, Neio, Rego, Lorena, Almeida, Maria da Glória Bonecini, Kritski, Afrânio L., Ho, John L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43798
Resumo: FIRST BRAZILIAN SYMPOSIUM ON BASIC RESEARCH IN HIV/ AIDS
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spelling Silva, José R. Lapa eLinhares, CristianeBoechat, NeioRego, LorenaAlmeida, Maria da Glória BoneciniKritski, Afrânio L.Ho, John L.2020-10-05T14:11:53Z2020-10-05T14:11:53Z1996SILVA, José R. Lapa e et al. Phenotypes of lung mononuclear phagocytes in HIV seronegative tuberculosis patients: evidence for new recruitment and cell activation. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 91, n. 3, p. 389-394, May/June 1996.0074-0276https://www.arca.fiocruz.br/handle/icict/4379810.1590/S0074-027619960003000261678-8060FIRST BRAZILIAN SYMPOSIUM ON BASIC RESEARCH IN HIV/ AIDSFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Hospital Evandro Chagas. Laboratório de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar de Pesquisa e Serviço de Pneumologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar de Pesquisa e Serviço de Pneumologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar de Pesquisa e Serviço de Pneumologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Humana. Rio de Janeiro, RJ, Brasil.Cornell University Medical College. Division of International Medicine and Infectious Diseases. New York, NY, USA.Cornell University Medical College. Division of International Medicine and Infectious Diseases. New York, NY, USA.Mycobacterium tuberculosis preferentially resides in mononuclear phagocytes. The mechanisms by which mononuclear phagocytes keep M. tuberculosis in check or by which the microbe evades control to cause disease remain poorly understood. As an initial effort to delineate these mechanisms, we examined by immunostaining the phenotype of mononuclear phagocytes obtained from lungs of patients with active tuberculosis. From August 1994 to March 1995, consecutive patients who had an abnormal chest X-ray, no demostrable acid-fast bacilli in sputum specimens and required a diagnostic bronchoalveolar lavage (BAL) were enrolled. Of the 39 patients enrolled, 21 had microbiologically diagnosed tuberculosis. Thirteen of the 21 tuberculosis patients were either HIV seronegative (n = 12) or had no risk factor for HIV and constituted the tuberculosis group. For comparison, M. tuberculosis negative patients who had BAL samples taken during this time (n = 9) or normal healthy volunteers (n = 3) served as control group. Compared to the control group, the tuberculosis group had significantly higher proportion of cells expressing markers of young monocytes (UCHM1) and RFD7, a marker for phagocytic cells, and increased expression of HLA-DR, a marker of cell activation. In addition, tuberculosis group had significantly higher proportion of cells expressing dendritic cell marker (RFD1) and epithelioid cell marker (RFD9). These data suggest that despite recruitment of monocytes probably from the peripheral blood and local cell activation, host defense of the resident lung cells is insufficient to control M. tuberculosis.engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Tuberculose pulmonarMacrófagos alveolaresAtivaçãoAnticorpos monoclonaisPulmonary tuberculosisAlveolar macrophagesActivationMonoclonal antibodiesPhenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Phenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activation
title Phenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activation
spellingShingle Phenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activation
Silva, José R. Lapa e
Tuberculose pulmonar
Macrófagos alveolares
Ativação
Anticorpos monoclonais
Pulmonary tuberculosis
Alveolar macrophages
Activation
Monoclonal antibodies
title_short Phenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activation
title_full Phenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activation
title_fullStr Phenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activation
title_full_unstemmed Phenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activation
title_sort Phenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activation
author Silva, José R. Lapa e
author_facet Silva, José R. Lapa e
Linhares, Cristiane
Boechat, Neio
Rego, Lorena
Almeida, Maria da Glória Bonecini
Kritski, Afrânio L.
Ho, John L.
author_role author
author2 Linhares, Cristiane
Boechat, Neio
Rego, Lorena
Almeida, Maria da Glória Bonecini
Kritski, Afrânio L.
Ho, John L.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, José R. Lapa e
Linhares, Cristiane
Boechat, Neio
Rego, Lorena
Almeida, Maria da Glória Bonecini
Kritski, Afrânio L.
Ho, John L.
dc.subject.other.pt_BR.fl_str_mv Tuberculose pulmonar
Macrófagos alveolares
Ativação
Anticorpos monoclonais
topic Tuberculose pulmonar
Macrófagos alveolares
Ativação
Anticorpos monoclonais
Pulmonary tuberculosis
Alveolar macrophages
Activation
Monoclonal antibodies
dc.subject.en.pt_BR.fl_str_mv Pulmonary tuberculosis
Alveolar macrophages
Activation
Monoclonal antibodies
description FIRST BRAZILIAN SYMPOSIUM ON BASIC RESEARCH IN HIV/ AIDS
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2020-10-05T14:11:53Z
dc.date.available.fl_str_mv 2020-10-05T14:11:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, José R. Lapa e et al. Phenotypes of lung mononuclear phagocytes in HIV seronegative tuberculosis patients: evidence for new recruitment and cell activation. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 91, n. 3, p. 389-394, May/June 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43798
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761996000300026
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SILVA, José R. Lapa e et al. Phenotypes of lung mononuclear phagocytes in HIV seronegative tuberculosis patients: evidence for new recruitment and cell activation. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 91, n. 3, p. 389-394, May/June 1996.
0074-0276
10.1590/S0074-02761996000300026
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43798
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/43798/1/license.txt
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