Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study

Detalhes bibliográficos
Autor(a) principal: Nassar Jr, Antonio P.
Data de Publicação: 2022
Outros Autores: Archanjo, Letícia V. F., Ranzani, Otavio T., Zampieri, Fernando G., Salluh, Jorge I. F., Cavalcanti, Genes F. R., Moreira, Carlos E. N., Viana, William N., Costa, Roberto, Melo, Ulisses O., Roderjan, Christian N., Correa, Thiago D., Almeida, Samantha L. S. de, Azevedo, Luciano C. P., Maia, Marcelo O., Cravo, Victor S., Bozza, Fernando A., Caruso, Pedro, Soares, Márcio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53485
Resumo: A.C. Camargo Cancer Center. ICU. São Paulo, SP, Brazil.
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spelling Nassar Jr, Antonio P.Archanjo, Letícia V. F.Ranzani, Otavio T.Zampieri, Fernando G.Salluh, Jorge I. F.Cavalcanti, Genes F. R.Moreira, Carlos E. N.Viana, William N.Costa, RobertoMelo, Ulisses O.Roderjan, Christian N.Correa, Thiago D.Almeida, Samantha L. S. deAzevedo, Luciano C. P.Maia, Marcelo O.Cravo, Victor S.Bozza, Fernando A.Caruso, PedroSoares, Márcio2022-06-26T19:06:01Z2022-06-26T19:06:01Z2022NASSAR JR, Antonio P. et al. Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study. Journal of critical care, v. 71, p. 1-5, 20220883-9441https://www.arca.fiocruz.br/handle/icict/5348510.1016/j.jcrc.2022.154077engElsevierCharacteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleA.C. Camargo Cancer Center. ICU. São Paulo, SP, Brazil.A.C. Camargo Cancer Center. ICU. São Paulo, SP, Brazil.ISGlobal. Barcelona Institute for Global Health. Barcelona, Spain / Universidade de São Paulo. Faculty of Medicine. Hospital das Clínicas. Heart Institute. Pulmonary Division. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Department of Critical Care. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Department of Critical Care. Rio de Janeiro, RJ, Brazil.Real Hospital Português de Beneficiência Portuguesa. ICU. Recife, PE, Brazil.Hospital 9 de Julho. ICU. São Paulo, SP, Brazil.Hospital Copa D'Or. ICU. Rio de Janeiro, RJ, Brazil.Hospital Quinta D'Or. ICU. Rio de Janeiro, RJ, Brazil.Hospital Estadual Alberto Torres. ICU. São Gonçalo, RJ, Brazil.Hospital São Lucas Copacabana. ICU. Rio de Janeiro, RJ, Brazil.Hospital Israelita Albert Einstein. ICU. São Paulo, SP, Brazil.Hospital Samaritano Higienópolis. ICU. São Paulo, SP, Brazil.Hospital Sírio Libanês. ICU. São Paulo, SP, Brazil.Hospital Santa Luzia. ICU. Brasília, DF, Brazil.Hospital Américas. ICU. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade de São Paulo. Faculty of Medicine. Hospital das Clínicas. Heart Institute. Pulmonary Division. São Paulo, SP, Brazil.A.C. Camargo Cancer Center. ICU. São Paulo, SP, Brazil / Universidade de São Paulo. Faculty of Medicine. Hospital das Clínicas. Heart Institute. Pulmonary Division. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Department of Critical Care. Rio de Janeiro, RJ, Brazil.Purpose: Studies of critically ill hematopoietic stem cell transplantation (HSCT) recipients have mainly been single-center and focused on allogenic HSCT recipients. We aimed to describe a cohort of autologous HSCT with an unplanned intensive care unit (ICU) admission. Methods: This study is a retrospective cohort study of autologous HSCT performed as a treatment for a hematological malignancy, during their first unplanned ICU admission in 50 hospitals in Brazil. We assessed the hospital mortality and the association between mechanical ventilation, vasopressors, and renal replacement therapy and hospital mortality in autologous HSCT recipients, adjusted for potential confounders. Results: We included 301 patients. Multiple myeloma was the most common malignancy driving to HSCT. ICU and hospital mortality were 22.9% and 37.5%, respectively. After adjustment for potential confounders, mechanical ventilation (OR = 9.10; CI 95%, 4.82-17.15) was associated with hospital mortality, but vasopressors (OR = 1.43; CI 95%, 0.77-2.64) and renal replacement therapy (OR = 1.30; CI 95%, 0.63-2.66) were not. Conclusions: In this large cohort of critically ill autologous HSCT recipients, mechanical ventilation was the only organ support-therapy associated with increased mortality in autologous HSCT recipients.Critical careHematopoietic stem cell transplantationMechanical ventilationMortalityRenal replacement therapyVasoconstrictor agentsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/53485/1/license.txt73c2438d9038594f05d706f987b602c3MD51ORIGINALCharacteristics_Fernando_Bozza_etal_INI_2022.pdfCharacteristics_Fernando_Bozza_etal_INI_2022.pdfapplication/pdf569275https://www.arca.fiocruz.br/bitstream/icict/53485/2/Characteristics_Fernando_Bozza_etal_INI_2022.pdffb4d0fbc15691d122e898e76b2b5caa3MD52icict/534852022-06-26 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dc.title.pt_BR.fl_str_mv Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study
title Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study
spellingShingle Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study
Nassar Jr, Antonio P.
Critical care
Hematopoietic stem cell transplantation
Mechanical ventilation
Mortality
Renal replacement therapy
Vasoconstrictor agents
title_short Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study
title_full Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study
title_fullStr Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study
title_full_unstemmed Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study
title_sort Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study
author Nassar Jr, Antonio P.
author_facet Nassar Jr, Antonio P.
Archanjo, Letícia V. F.
Ranzani, Otavio T.
Zampieri, Fernando G.
Salluh, Jorge I. F.
Cavalcanti, Genes F. R.
Moreira, Carlos E. N.
Viana, William N.
Costa, Roberto
Melo, Ulisses O.
Roderjan, Christian N.
Correa, Thiago D.
Almeida, Samantha L. S. de
Azevedo, Luciano C. P.
Maia, Marcelo O.
Cravo, Victor S.
Bozza, Fernando A.
Caruso, Pedro
Soares, Márcio
author_role author
author2 Archanjo, Letícia V. F.
Ranzani, Otavio T.
Zampieri, Fernando G.
Salluh, Jorge I. F.
Cavalcanti, Genes F. R.
Moreira, Carlos E. N.
Viana, William N.
Costa, Roberto
Melo, Ulisses O.
Roderjan, Christian N.
Correa, Thiago D.
Almeida, Samantha L. S. de
Azevedo, Luciano C. P.
Maia, Marcelo O.
Cravo, Victor S.
Bozza, Fernando A.
Caruso, Pedro
Soares, Márcio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nassar Jr, Antonio P.
Archanjo, Letícia V. F.
Ranzani, Otavio T.
Zampieri, Fernando G.
Salluh, Jorge I. F.
Cavalcanti, Genes F. R.
Moreira, Carlos E. N.
Viana, William N.
Costa, Roberto
Melo, Ulisses O.
Roderjan, Christian N.
Correa, Thiago D.
Almeida, Samantha L. S. de
Azevedo, Luciano C. P.
Maia, Marcelo O.
Cravo, Victor S.
Bozza, Fernando A.
Caruso, Pedro
Soares, Márcio
dc.subject.en.pt_BR.fl_str_mv Critical care
Hematopoietic stem cell transplantation
Mechanical ventilation
Mortality
Renal replacement therapy
Vasoconstrictor agents
topic Critical care
Hematopoietic stem cell transplantation
Mechanical ventilation
Mortality
Renal replacement therapy
Vasoconstrictor agents
description A.C. Camargo Cancer Center. ICU. São Paulo, SP, Brazil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-06-26T19:06:01Z
dc.date.available.fl_str_mv 2022-06-26T19:06:01Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NASSAR JR, Antonio P. et al. Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study. Journal of critical care, v. 71, p. 1-5, 2022
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53485
dc.identifier.issn.pt_BR.fl_str_mv 0883-9441
dc.identifier.doi.none.fl_str_mv 10.1016/j.jcrc.2022.154077
identifier_str_mv NASSAR JR, Antonio P. et al. Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study. Journal of critical care, v. 71, p. 1-5, 2022
0883-9441
10.1016/j.jcrc.2022.154077
url https://www.arca.fiocruz.br/handle/icict/53485
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53485/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53485/2/Characteristics_Fernando_Bozza_etal_INI_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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