Flavonoids as molecules with anti-Zika virus activity

Detalhes bibliográficos
Autor(a) principal: Cataneo, Allan Henrique Depieri
Data de Publicação: 2021
Outros Autores: Ávila, Eloah Pereira, Mendes, Larissa Albuquerque de Oliveira, Oliveira, Viviane Guedes de, Ferraz, Camila Rodrigues, Almeida, Mauro Vieira de, Frabasile, Sandra, Santos, Claudia Nunes Duarte dos, Verri Júnior, Waldiceu Aparecido, Bordignon, Juliano, Wowk, Pryscilla Fanini
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49743
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
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spelling Cataneo, Allan Henrique DepieriÁvila, Eloah PereiraMendes, Larissa Albuquerque de OliveiraOliveira, Viviane Guedes deFerraz, Camila RodriguesAlmeida, Mauro Vieira deFrabasile, SandraSantos, Claudia Nunes Duarte dosVerri Júnior, Waldiceu AparecidoBordignon, JulianoWowk, Pryscilla Fanini2021-11-09T15:33:28Z2021-11-09T15:33:28Z2021CATANEO, Allan Henrique Depieri et al. Flavonoids as molecules with anti-Zika virus activity. Frontiers in Microbiology, v. 12, n. 710359, p. 1-16, 2021.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/4974310.3389/fmicb.2021.710359porFrontiers MediaFlavonoids as molecules with anti-Zika virus activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Londrina, PR, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidad de la República. Facultad de Ciencias. Sección Virologia. Montevideo, Uruguay.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Londrina, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Zika virus (ZIKV) is an arthropod-born virus that is mainly transmitted to humans by mosquitoes of the genus Aedes spp. Since its first isolation in 1947, only a few human cases had been described until large outbreaks occurred on Yap Island (2007), French Polynesia (2013), and Brazil (2015). Most ZIKV-infected individuals are asymptomatic or present with a self-limiting disease and nonspecific symptoms such as fever, myalgia, and headache. However, in French Polynesia and Brazil, ZIKV outbreaks led to the diagnosis of congenital malformations and microcephaly in newborns and Guillain-Barré syndrome (GBS) in adults. These new clinical presentations raised concern from public health authorities and highlighted the need for anti-Zika treatments and vaccines to control the neurological damage caused by the virus. Despite many efforts in the search for an effective treatment, neither vaccines nor antiviral drugs have become available to control ZIKV infection and/or replication. Flavonoids, a class of natural compounds that are well-known for possessing several biological properties, have shown activity against different viruses. Additionally, the use of flavonoids in some countries as food supplements indicates that these molecules are nontoxic to humans. Thus, here, we summarize knowledge on the use of flavonoids as a source of anti-ZIKV molecules and discuss the gaps and challenges in this area before these compounds can be considered for further preclinical and clinical trials.Antiviral AgentsFlavonoidsBiological ProductsVirus ZikaTherapeuticsAntiviralesFlavonoidesProductos BiológicosTerapéuticaAntivirauxFlavonoïdesProduits biologiquesThérapeutiqueAntiviraisFlavonoidesProdutos BiológicosZika virusTerapêuticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/49743/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfmicb-12-710359OK.pdffmicb-12-710359OK.pdfapplication/pdf2260479https://www.arca.fiocruz.br/bitstream/icict/49743/2/fmicb-12-710359OK.pdff826fd80e9ef8f2f4b6df5138590aef4MD52icict/497432021-11-17 20:28:16.73oai:www.arca.fiocruz.br:icict/49743Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUw0KDQpNYW5vZWwgQmFyYXRhLCBDUEY6IDA3MC43NjQuMzM3LTYxLCB2aW5jdWxhZG8gYSBGaW9jcnV6IFBhcmFuw6EgLSBJbnN0aXR1dG8gQ2FybG9zIENoYWdhcwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório 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dc.title.pt_BR.fl_str_mv Flavonoids as molecules with anti-Zika virus activity
title Flavonoids as molecules with anti-Zika virus activity
spellingShingle Flavonoids as molecules with anti-Zika virus activity
Cataneo, Allan Henrique Depieri
Antiviral Agents
Flavonoids
Biological Products
Virus Zika
Therapeutics
Antivirales
Flavonoides
Productos Biológicos
Terapéutica
Antiviraux
Flavonoïdes
Produits biologiques
Thérapeutique
Antivirais
Flavonoides
Produtos Biológicos
Zika virus
Terapêutica
title_short Flavonoids as molecules with anti-Zika virus activity
title_full Flavonoids as molecules with anti-Zika virus activity
title_fullStr Flavonoids as molecules with anti-Zika virus activity
title_full_unstemmed Flavonoids as molecules with anti-Zika virus activity
title_sort Flavonoids as molecules with anti-Zika virus activity
author Cataneo, Allan Henrique Depieri
author_facet Cataneo, Allan Henrique Depieri
Ávila, Eloah Pereira
Mendes, Larissa Albuquerque de Oliveira
Oliveira, Viviane Guedes de
Ferraz, Camila Rodrigues
Almeida, Mauro Vieira de
Frabasile, Sandra
Santos, Claudia Nunes Duarte dos
Verri Júnior, Waldiceu Aparecido
Bordignon, Juliano
Wowk, Pryscilla Fanini
author_role author
author2 Ávila, Eloah Pereira
Mendes, Larissa Albuquerque de Oliveira
Oliveira, Viviane Guedes de
Ferraz, Camila Rodrigues
Almeida, Mauro Vieira de
Frabasile, Sandra
Santos, Claudia Nunes Duarte dos
Verri Júnior, Waldiceu Aparecido
Bordignon, Juliano
Wowk, Pryscilla Fanini
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cataneo, Allan Henrique Depieri
Ávila, Eloah Pereira
Mendes, Larissa Albuquerque de Oliveira
Oliveira, Viviane Guedes de
Ferraz, Camila Rodrigues
Almeida, Mauro Vieira de
Frabasile, Sandra
Santos, Claudia Nunes Duarte dos
Verri Júnior, Waldiceu Aparecido
Bordignon, Juliano
Wowk, Pryscilla Fanini
dc.subject.en.pt_BR.fl_str_mv Antiviral Agents
Flavonoids
Biological Products
Virus Zika
Therapeutics
topic Antiviral Agents
Flavonoids
Biological Products
Virus Zika
Therapeutics
Antivirales
Flavonoides
Productos Biológicos
Terapéutica
Antiviraux
Flavonoïdes
Produits biologiques
Thérapeutique
Antivirais
Flavonoides
Produtos Biológicos
Zika virus
Terapêutica
dc.subject.es.pt_BR.fl_str_mv Antivirales
Flavonoides
Productos Biológicos
Terapéutica
dc.subject.fr.pt_BR.fl_str_mv Antiviraux
Flavonoïdes
Produits biologiques
Thérapeutique
dc.subject.decs.pt_BR.fl_str_mv Antivirais
Flavonoides
Produtos Biológicos
Zika virus
Terapêutica
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-09T15:33:28Z
dc.date.available.fl_str_mv 2021-11-09T15:33:28Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CATANEO, Allan Henrique Depieri et al. Flavonoids as molecules with anti-Zika virus activity. Frontiers in Microbiology, v. 12, n. 710359, p. 1-16, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49743
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2021.710359
identifier_str_mv CATANEO, Allan Henrique Depieri et al. Flavonoids as molecules with anti-Zika virus activity. Frontiers in Microbiology, v. 12, n. 710359, p. 1-16, 2021.
1664-302X
10.3389/fmicb.2021.710359
url https://www.arca.fiocruz.br/handle/icict/49743
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/49743/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/49743/2/fmicb-12-710359OK.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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