Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56098 |
Resumo: | This Article is part of the Research Topic Conference Resarch Topic: 16th International Symposium on Schistosomiasis |
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Mesquita, Silvia GonçalvesCaldeira, Roberta LimaFavre, Tereza CristinaMassara, Cristiano LaraBeck, Lílian Christina Nóbrega HolsbachSimões, Taynãna CésarCarvalho, Gardênia Braz Figueiredo deNeves, Flória Gabriela dos SantosOliveira, Gabriela deLacerda, Larisse de Souza BarbosaAlmeida, Matheus Alves deCarvalho, Omar dos SantosMourão, Marina MoraesOliveira, EdwardPereira, Rosane A. SilvaFonseca, Cristina Toscano2022-12-20T20:17:37Z2022-12-20T20:17:37Z2022-12-15MESQUITA, Silvia Gonçalves et al. Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis. Frontiers in Microbiology, p. 1 - 20, Dec. 2022.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/5609810.3389/fmicb.2022.1048457This Article is part of the Research Topic Conference Resarch Topic: 16th International Symposium on SchistosomiasisFundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Helmintologia e Malacologia Médica. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Helmintologia e Malacologia Médica. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Helmintologia e Malacologia Médica. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René-Rachou. Núcleo de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Grupo de Pesquisa em Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Helmintologia e Malacologia Médica. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Grupo de Pesquisa em Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Grupo de Pesquisa em Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Genômica Funcional de Parasitos. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Helmintologia e Malacologia Médica. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Helmintologia e Malacologia Médica. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Genômica Funcional de Parasitos. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Grupo de Pesquisa em Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Grupo de Pesquisa em Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil.Background: Schistosomiasis is a parasitic disease associated with poverty. It is estimated that 7.1 million people are infected with Schistosoma mansoni in Latin America, with 95% of them living in Brazil. Accurate diagnosis and timely treatment are important measures to control and eliminate schistosomiasis, but diagnostic improvements are needed to detect infections, especially in areas of low endemicity. Methodology: This research aimed to evaluate the performance of 11 diagnostic tests using latent class analysis (LCA). A cross-sectional survey was undertaken in a low endemicity area of the municipality of Malacacheta, Minas Gerais, Brazil. Feces, urine, and blood samples were collected from 400 residents older than 6 years of age, who had not been treated with praziquantel in the 12 months previous to the collection of their samples. The collected samples were examined using parasitological (Helm Test® kit Kato-Katz), nucleic acid amplification tests -NAATs (PCR, qPCR and LAMP on urine; PCR-ELISA, qPCR and LAMP on stool), and immunological (POC-CCA, the commercial anti-Schistosoma mansoni IgG ELISA kit from Euroimmun, and two in-house ELISA assays using either the recombinant antigen PPE or the synthetic peptide Smp150390.1) tests. Results: The positivity rate of the 11 tests evaluated ranged from 5% (qPCR on urine) to 40.8% (commercial ELISA kit). The estimated prevalence of schistosomiasis was 12% (95% CI: 9–15%) according to the LCA. Among all tests assessed, the commercial ELISA kit had the highest estimated sensitivity (100%), while the Kato-Katz had the highest estimated specificity (99%). Based on the accuracy measures observed, we proposed three 2-step diagnostic approaches for the active search of infected people in endemic settings. The approaches proposed consist of combinations of commercial ELISA kit and NAATs tests performed on stool. All the approaches had higher sensitivity and specificity than the mean values observed for the 11 tests (70.4 and 89.5%, respectively). Conclusion: We showed that it is possible to achieve high specificity and sensitivity rates with lower costs by combining serological and NAATs tests, which would assist in the decision-making process for appropriate allocation of public funding aiming to achieve the WHO target of eliminating schistosomiasis as a public health problem by 2030.engFrontiers MediaIEsquistossomoseSchistosoma mansoniTestes de diagnósticoDiagnósticoAnálise de classe latentePesquisa ClinicaSensibilidadeEspecificidadeSchistosomiasisSchistosoma mansoniDiagnostic testsDiagnosisLatent class analysisSensitivitySpecificityClinical researchAssessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAssessment of the accuracy of eleven different diagnostic tests for the detection of schistosomiasis.pdfAssessment of the accuracy of eleven different diagnostic tests for the detection of schistosomiasis.pdfapplication/pdf5598390https://www.arca.fiocruz.br/bitstream/icict/56098/2/Assessment%20of%20the%20accuracy%20of%20eleven%20different%20diagnostic%20tests%20for%20the%20detection%20of%20schistosomiasis.pdf30f15578a9f94fd4b8d828e72873b5b7MD52LICENSElicense.txtlicense.txttext/plain; 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| dc.title.en_US.fl_str_mv |
Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis |
| title |
Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis |
| spellingShingle |
Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis Mesquita, Silvia Gonçalves Esquistossomose Schistosoma mansoni Testes de diagnóstico Diagnóstico Análise de classe latente Pesquisa Clinica Sensibilidade Especificidade Schistosomiasis Schistosoma mansoni Diagnostic tests Diagnosis Latent class analysis Sensitivity Specificity Clinical research |
| title_short |
Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis |
| title_full |
Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis |
| title_fullStr |
Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis |
| title_full_unstemmed |
Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis |
| title_sort |
Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis |
| author |
Mesquita, Silvia Gonçalves |
| author_facet |
Mesquita, Silvia Gonçalves Caldeira, Roberta Lima Favre, Tereza Cristina Massara, Cristiano Lara Beck, Lílian Christina Nóbrega Holsbach Simões, Taynãna César Carvalho, Gardênia Braz Figueiredo de Neves, Flória Gabriela dos Santos Oliveira, Gabriela de Lacerda, Larisse de Souza Barbosa Almeida, Matheus Alves de Carvalho, Omar dos Santos Mourão, Marina Moraes Oliveira, Edward Pereira, Rosane A. Silva Fonseca, Cristina Toscano |
| author_role |
author |
| author2 |
Caldeira, Roberta Lima Favre, Tereza Cristina Massara, Cristiano Lara Beck, Lílian Christina Nóbrega Holsbach Simões, Taynãna César Carvalho, Gardênia Braz Figueiredo de Neves, Flória Gabriela dos Santos Oliveira, Gabriela de Lacerda, Larisse de Souza Barbosa Almeida, Matheus Alves de Carvalho, Omar dos Santos Mourão, Marina Moraes Oliveira, Edward Pereira, Rosane A. Silva Fonseca, Cristina Toscano |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mesquita, Silvia Gonçalves Caldeira, Roberta Lima Favre, Tereza Cristina Massara, Cristiano Lara Beck, Lílian Christina Nóbrega Holsbach Simões, Taynãna César Carvalho, Gardênia Braz Figueiredo de Neves, Flória Gabriela dos Santos Oliveira, Gabriela de Lacerda, Larisse de Souza Barbosa Almeida, Matheus Alves de Carvalho, Omar dos Santos Mourão, Marina Moraes Oliveira, Edward Pereira, Rosane A. Silva Fonseca, Cristina Toscano |
| dc.subject.other.en_US.fl_str_mv |
Esquistossomose Schistosoma mansoni Testes de diagnóstico Diagnóstico Análise de classe latente Pesquisa Clinica Sensibilidade Especificidade |
| topic |
Esquistossomose Schistosoma mansoni Testes de diagnóstico Diagnóstico Análise de classe latente Pesquisa Clinica Sensibilidade Especificidade Schistosomiasis Schistosoma mansoni Diagnostic tests Diagnosis Latent class analysis Sensitivity Specificity Clinical research |
| dc.subject.en.en_US.fl_str_mv |
Schistosomiasis Schistosoma mansoni Diagnostic tests Diagnosis Latent class analysis Sensitivity Specificity Clinical research |
| description |
This Article is part of the Research Topic Conference Resarch Topic: 16th International Symposium on Schistosomiasis |
| publishDate |
2022 |
| dc.date.accessioned.fl_str_mv |
2022-12-20T20:17:37Z |
| dc.date.available.fl_str_mv |
2022-12-20T20:17:37Z |
| dc.date.issued.fl_str_mv |
2022-12-15 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
MESQUITA, Silvia Gonçalves et al. Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis. Frontiers in Microbiology, p. 1 - 20, Dec. 2022. |
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https://www.arca.fiocruz.br/handle/icict/56098 |
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1664-302X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2022.1048457 |
| identifier_str_mv |
MESQUITA, Silvia Gonçalves et al. Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis. Frontiers in Microbiology, p. 1 - 20, Dec. 2022. 1664-302X 10.3389/fmicb.2022.1048457 |
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https://www.arca.fiocruz.br/handle/icict/56098 |
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eng |
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eng |
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openAccess |
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Frontiers Media |
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Frontiers Media |
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