Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil

Detalhes bibliográficos
Autor(a) principal: Dalla Costa, Elis R.
Data de Publicação: 2015
Outros Autores: Vasconcelos, Sidra E. G., Esteves, Leonardo S., Gomes, Harrison M., Gomes, Lia L., Silva, Pedro Almeida da, Perdigão, João, Portugal, Isabel, Viveiros, Miguel, McNerney, Ruth, Pain, Arnab, Clark, Taane G., Rastogi, Nalin, Unis, Gisela, Rossetti, Maria Lucia R., Suffys, Philip Noel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23846
Resumo: Fundação Estadual de Produção e Pesquisa em Saúde. Porto Alegre, RS, Brasil.
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spelling Dalla Costa, Elis R.Vasconcelos, Sidra E. G.Esteves, Leonardo S.Gomes, Harrison M.Gomes, Lia L.Silva, Pedro Almeida daPerdigão, JoãoPortugal, IsabelViveiros, MiguelMcNerney, RuthPain, ArnabClark, Taane G.Rastogi, NalinUnis, GiselaRossetti, Maria Lucia R.Suffys, Philip Noel2018-01-02T16:05:14Z2018-01-02T16:05:14Z2015DALLA COSTA, Elis R. et al. Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil. Journal of Clinical Microbiology, v.53, n.12, p.3805-3811, Dec. 2015.0095-1137https://www.arca.fiocruz.br/handle/icict/2384610.1128/JCM.02012-151098-660XengAmerican Society for MicrobiologyTuberculoseMycobacterium tuberculosisResistência a medicamentosMycobacterium pinnipediiAmérica LatinaLinhagem BrasileiraSul do BrasilTuberculosisMycobacterium tuberculosisMultidrug-ResistantMycobacterium pinnipediiLatin AmericaMediterranean lineageSouth BrazilMultidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Estadual de Produção e Pesquisa em Saúde. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Porto Alegre, RS, Brasil / Universidade Luterana do Brasil. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio Grande.Faculdade de Medicina. Nùcleo de Pesquisa em Biologia Médica. Rio Grande, RS, Brasil.Universidade de Lisboa. Faculdade de Farmácia. Instituto de Investigação do Medicamento. Lisboa, Portugal.Universidade de Lisboa. Faculdade de Farmácia. Instituto de Investigação do Medicamento. Lisboa, Portugal.Universidade Nova de Lisboa. Instituto de Higiene e Medicina Tropical. Unidade de Microbiologia Médica. Saúde Global e Medicina Tropical. Lisboa, Portugal.London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, United Kingdom.King Abdullah University of Science and Technology. Biological and Environmental Sciences and Engineering Division. Thuwal, Kingdom of Saudi Arabia.London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, United Kingdom / London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, United Kingdom.Institut Pasteur de Guadeloupe. Unité de la Tuberculose et des Mycobactéries. Les Abymes, Guadeloupe, France.Hospital Sanatório Partenon. Porto Alegre, RS, Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Porto Alegre, RS, Brasil / Universidade Luterana do Brasil. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil / Unit of Mycobacteriology at the Institute of Tropical Medicine. Antwerp, Belgium.We recently detected the spoligotype patterns of strains of Mycobacterium pinnipedii, a species of the Mycobacterium tuberculosis complex, in sputum samples from nine cases with pulmonary tuberculosis residing in Porto Alegre, South Brazil. Because this species is rarely encountered in humans, we further characterized these nine isolates by additional genotyping techniques, including 24-locus mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing, verification of the loci TbD1, RD9, pks15/1, RD(Rio), and fbpC, the insertion of IS6110 at a site specific to the M. tuberculosis Latin American Mediterranean (LAM) lineage, and whole-genome sequencing. The combined analysis of these markers revealed that the isolates are in fact M. tuberculosis and more specifically belong to the LAM genotype. Most of these isolates (n8) were shown to be multidrug resistant (MDR), which prompted us to perform partial sequencing of the rpoA, rpoB, rpoC, katG, and inhA genes. Seven isolates (77.8%) carried the S315T mutation in katG, and one of these (11%) also presented the C((-17)T single-nucleotide polymorphism (SNP) in inhA. Interestingly, six of the MDR isolates also presented an undescribed insertion of 12 nucleotides (CCA GAA CAA CCC) in codon 516 of rpoB. No putative compensatory mutation was found in either rpoA or rpoC. This is the first report of an M. tuberculosis LAM family strain with a convergent M. pinnipedii spoligotype. These spoligotypes are observed in genotype databases at a modest frequency, highlighting that care must be taken when identifying isolates in the M. tuberculosis complex on the basis of single genetic markers.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23846/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALsidra_vasconcelos_etal_IOC_2015.pdfsidra_vasconcelos_etal_IOC_2015.pdfapplication/pdf955091https://www.arca.fiocruz.br/bitstream/icict/23846/2/sidra_vasconcelos_etal_IOC_2015.pdf9b7d4861ee5603cecd653468d8e11b77MD52TEXTsidra_vasconcelos_etal_IOC_2015.pdf.txtsidra_vasconcelos_etal_IOC_2015.pdf.txtExtracted texttext/plain47389https://www.arca.fiocruz.br/bitstream/icict/23846/3/sidra_vasconcelos_etal_IOC_2015.pdf.txta9820bb41f8e1cb77a60c38d04d49fc3MD53icict/238462018-08-15 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dc.title.pt_BR.fl_str_mv Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil
title Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil
spellingShingle Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil
Dalla Costa, Elis R.
Tuberculose
Mycobacterium tuberculosis
Resistência a medicamentos
Mycobacterium pinnipedii
América Latina
Linhagem Brasileira
Sul do Brasil
Tuberculosis
Mycobacterium tuberculosis
Multidrug-Resistant
Mycobacterium pinnipedii
Latin America
Mediterranean lineage
South Brazil
title_short Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil
title_full Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil
title_fullStr Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil
title_full_unstemmed Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil
title_sort Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil
author Dalla Costa, Elis R.
author_facet Dalla Costa, Elis R.
Vasconcelos, Sidra E. G.
Esteves, Leonardo S.
Gomes, Harrison M.
Gomes, Lia L.
Silva, Pedro Almeida da
Perdigão, João
Portugal, Isabel
Viveiros, Miguel
McNerney, Ruth
Pain, Arnab
Clark, Taane G.
Rastogi, Nalin
Unis, Gisela
Rossetti, Maria Lucia R.
Suffys, Philip Noel
author_role author
author2 Vasconcelos, Sidra E. G.
Esteves, Leonardo S.
Gomes, Harrison M.
Gomes, Lia L.
Silva, Pedro Almeida da
Perdigão, João
Portugal, Isabel
Viveiros, Miguel
McNerney, Ruth
Pain, Arnab
Clark, Taane G.
Rastogi, Nalin
Unis, Gisela
Rossetti, Maria Lucia R.
Suffys, Philip Noel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dalla Costa, Elis R.
Vasconcelos, Sidra E. G.
Esteves, Leonardo S.
Gomes, Harrison M.
Gomes, Lia L.
Silva, Pedro Almeida da
Perdigão, João
Portugal, Isabel
Viveiros, Miguel
McNerney, Ruth
Pain, Arnab
Clark, Taane G.
Rastogi, Nalin
Unis, Gisela
Rossetti, Maria Lucia R.
Suffys, Philip Noel
dc.subject.other.pt_BR.fl_str_mv Tuberculose
Mycobacterium tuberculosis
Resistência a medicamentos
Mycobacterium pinnipedii
América Latina
Linhagem Brasileira
Sul do Brasil
topic Tuberculose
Mycobacterium tuberculosis
Resistência a medicamentos
Mycobacterium pinnipedii
América Latina
Linhagem Brasileira
Sul do Brasil
Tuberculosis
Mycobacterium tuberculosis
Multidrug-Resistant
Mycobacterium pinnipedii
Latin America
Mediterranean lineage
South Brazil
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
Mycobacterium tuberculosis
Multidrug-Resistant
Mycobacterium pinnipedii
Latin America
Mediterranean lineage
South Brazil
description Fundação Estadual de Produção e Pesquisa em Saúde. Porto Alegre, RS, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2018-01-02T16:05:14Z
dc.date.available.fl_str_mv 2018-01-02T16:05:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv DALLA COSTA, Elis R. et al. Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil. Journal of Clinical Microbiology, v.53, n.12, p.3805-3811, Dec. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23846
dc.identifier.issn.pt_BR.fl_str_mv 0095-1137
dc.identifier.doi.none.fl_str_mv 10.1128/JCM.02012-15
dc.identifier.eissn.none.fl_str_mv 1098-660X
identifier_str_mv DALLA COSTA, Elis R. et al. Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil. Journal of Clinical Microbiology, v.53, n.12, p.3805-3811, Dec. 2015.
0095-1137
10.1128/JCM.02012-15
1098-660X
url https://www.arca.fiocruz.br/handle/icict/23846
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dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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