A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits

Detalhes bibliográficos
Autor(a) principal: Conteville, Liliane Costa
Data de Publicação: 2022
Outros Autores: Vicente, Ana Carolina Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56340
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
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spelling Conteville, Liliane CostaVicente, Ana Carolina Paulo2023-01-05T19:48:57Z2023-01-05T19:48:57Z2022Conteville, Liliane Costa; VICENTE, Ana Carolina Paulo. A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits. Scientifc Reports, v. 12, 12102, p. 1 - 9, 2022.2045-2322https://www.arca.fiocruz.br/handle/icict/5634010.1038/s41598-022-16392-zengNature PortfolioRede de plasmídeoIntestino microbiomaSemi-isolados grupos humanosCaracterísticas únicasMetabolismo e virulência compartilhadosPlasmid networkGut microbiomeSemi‑isolated human groupsReveals unique and shared metabolicVirulence traitsA plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traitsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.The plasmids in gut microbiomes have the potential to contribute to the microbiome community, as well as human health and physiology. Nevertheless, this niche remains poorly explored. In general, most microbiome studies focus on urban-industrialized groups, but here, we studied semi-isolated groups from South America and Africa, which would represent a link between ancestral and modern human groups. Based on open metagenomic data, we characterized the set of plasmids, including their genes and functions, from the gut microbiome of the Hadza, Matses, Tunapuco, and Yanomami, semi-isolated groups with a hunter, gather or subsistence lifestyle. Unique plasmid clusters and gene functions for each human group were identified. Moreover, a dozen plasmid clusters circulating in other niches worldwide are shared by these distinct groups. In addition, novel and unique plasmids harboring resistance (encompassing six antibiotic classes and multiple metals) and virulence (as type VI secretion systems) genes were identified. Functional analysis revealed pathways commonly associated with urban-industrialized groups, such as lipopolysaccharide biosynthesis that was characterized in the Hadza gut plasmids. These results demonstrate the richness of plasmids in semiisolated human groups’ gut microbiome, which represents an important source of information with biotechnological/pharmaceutical potential, but also on the spread of resistance/virulence genes to semi-isolated groups.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56340/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLilianeConteville_AnaCarolinaVicente_IOC_2022.pdfLilianeConteville_AnaCarolinaVicente_IOC_2022.pdfapplication/pdf2105896https://www.arca.fiocruz.br/bitstream/icict/56340/2/LilianeConteville_AnaCarolinaVicente_IOC_2022.pdfc0d2c4b7b165ae103264abc6e7146d5aMD52icict/563402023-09-04 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dc.title.en_US.fl_str_mv A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits
title A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits
spellingShingle A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits
Conteville, Liliane Costa
Rede de plasmídeo
Intestino microbioma
Semi-isolados grupos humanos
Características únicas
Metabolismo e virulência compartilhados
Plasmid network
Gut microbiome
Semi‑isolated human groups
Reveals unique and shared metabolic
Virulence traits
title_short A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits
title_full A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits
title_fullStr A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits
title_full_unstemmed A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits
title_sort A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits
author Conteville, Liliane Costa
author_facet Conteville, Liliane Costa
Vicente, Ana Carolina Paulo
author_role author
author2 Vicente, Ana Carolina Paulo
author2_role author
dc.contributor.author.fl_str_mv Conteville, Liliane Costa
Vicente, Ana Carolina Paulo
dc.subject.other.en_US.fl_str_mv Rede de plasmídeo
Intestino microbioma
Semi-isolados grupos humanos
Características únicas
Metabolismo e virulência compartilhados
topic Rede de plasmídeo
Intestino microbioma
Semi-isolados grupos humanos
Características únicas
Metabolismo e virulência compartilhados
Plasmid network
Gut microbiome
Semi‑isolated human groups
Reveals unique and shared metabolic
Virulence traits
dc.subject.en.en_US.fl_str_mv Plasmid network
Gut microbiome
Semi‑isolated human groups
Reveals unique and shared metabolic
Virulence traits
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-05T19:48:57Z
dc.date.available.fl_str_mv 2023-01-05T19:48:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Conteville, Liliane Costa; VICENTE, Ana Carolina Paulo. A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits. Scientifc Reports, v. 12, 12102, p. 1 - 9, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56340
dc.identifier.issn.en_US.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-022-16392-z
identifier_str_mv Conteville, Liliane Costa; VICENTE, Ana Carolina Paulo. A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits. Scientifc Reports, v. 12, 12102, p. 1 - 9, 2022.
2045-2322
10.1038/s41598-022-16392-z
url https://www.arca.fiocruz.br/handle/icict/56340
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Portfolio
publisher.none.fl_str_mv Nature Portfolio
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56340/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56340/2/LilianeConteville_AnaCarolinaVicente_IOC_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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