Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population

Detalhes bibliográficos
Autor(a) principal: Arnaldo, Paulo
Data de Publicação: 2013
Outros Autores: Thompson, Ricardo Estevão, Lopes, Márcia Quinhones, Suffys, Philip Noel, Santos, Adalberto Rezende
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11581
Resumo: Ministry of Health. National Institute of Health. Platform of Parasitology, Maputo, Mozambique.
id CRUZ_11968be95d33c3c2e69c4f111fe1f1d6
oai_identifier_str oai:www.arca.fiocruz.br:icict/11581
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Arnaldo, PauloThompson, Ricardo EstevãoLopes, Márcia QuinhonesSuffys, Philip NoelSantos, Adalberto Rezende2015-08-19T13:49:36Z2015-08-19T13:49:36Z2013ARNALDO, Paulo; et al. Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population. Malays J Med Sci., v.20, n.4, p.13-2, July 2013.https://www.arca.fiocruz.br/handle/icict/11581engPenerbit Universiti SainsFrequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMinistry of Health. National Institute of Health. Platform of Parasitology, Maputo, Mozambique.Ministry of Health. National Institute of Health. Platform of Parasitology, Maputo, Mozambique.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Background: The cytochrome P450 enzymes (CYP) play an important role in the metabolism of many therapeutic agents. The activities of different enzymes exhibit variability in different populations, which causes variations in drug response or toxicity. The CYP2B6 and CYP2C8 enzymes are encoded by polymorphic genes characterised by different single nucleotide polymorphisms (SNPs). Several of these CYP variants are often associated with slow metabolism phenotypes. This study aimed to analyse the frequencies of allelic variants of CYP2B6 and CYP2C8 in the Mozambican population. Methods: Using a polymerase chain reaction and restriction fragment length polymorphism assay (PCR-RFLP), the frequencies of the allelic variants of CYP2B6 (c.64C>T, c.516G>T, c.777C>A, c.785A>G, c.1459C>T) and CYP2C8 (c.805A>T, c.416G>A, c.1196A>G, c.792C>G) were determined in 360 Mozambican blood donors. Results: The frequencies of the allelic variants of the CYP2B6 gene were 0.057, 0.426, 0.0, 0.410, and 0.004. For the CYP2C8 gene, the frequencies of the allelic variants were 0.160, 0.048, 0.0, and 0.005. No significant differences were observed between the gender and geographic distribution of volunteers around the country. Conclusion: The frequencies of the allelic variants of the CYP2B6 and CYP2C8 genes were found to be homogeneously distributed in the Mozambican population and were comparable to other African populations. Further studies are required to explore the impact of these variants on the clinical response (efficacy and toxicity) of drugs, including antimalarials.Allele frequencyCYP2B6CYP2C8PolymorphismFrequência do GenePolimorfismo Genéticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11581/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALadalberto_santos_etal_IOC_2013.pdfapplication/pdf6213677https://www.arca.fiocruz.br/bitstream/icict/11581/2/adalberto_santos_etal_IOC_2013.pdf96b9bca7a3a2e3f706e18b81b56f82c5MD52TEXTadalberto_santos_etal_IOC_2013.pdf.txtadalberto_santos_etal_IOC_2013.pdf.txtExtracted texttext/plain40554https://www.arca.fiocruz.br/bitstream/icict/11581/3/adalberto_santos_etal_IOC_2013.pdf.txt70de9199ed2673cdd023194f240a9c36MD53icict/115812022-06-24 12:17:35.993oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:17:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population
title Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population
spellingShingle Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population
Arnaldo, Paulo
Allele frequency
CYP2B6
CYP2C8
Polymorphism
Frequência do Gene
Polimorfismo Genético
title_short Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population
title_full Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population
title_fullStr Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population
title_full_unstemmed Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population
title_sort Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population
author Arnaldo, Paulo
author_facet Arnaldo, Paulo
Thompson, Ricardo Estevão
Lopes, Márcia Quinhones
Suffys, Philip Noel
Santos, Adalberto Rezende
author_role author
author2 Thompson, Ricardo Estevão
Lopes, Márcia Quinhones
Suffys, Philip Noel
Santos, Adalberto Rezende
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Arnaldo, Paulo
Thompson, Ricardo Estevão
Lopes, Márcia Quinhones
Suffys, Philip Noel
Santos, Adalberto Rezende
dc.subject.en.pt_BR.fl_str_mv Allele frequency
CYP2B6
CYP2C8
Polymorphism
topic Allele frequency
CYP2B6
CYP2C8
Polymorphism
Frequência do Gene
Polimorfismo Genético
dc.subject.decs.pt_BR.fl_str_mv Frequência do Gene
Polimorfismo Genético
description Ministry of Health. National Institute of Health. Platform of Parasitology, Maputo, Mozambique.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-08-19T13:49:36Z
dc.date.available.fl_str_mv 2015-08-19T13:49:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARNALDO, Paulo; et al. Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population. Malays J Med Sci., v.20, n.4, p.13-2, July 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11581
identifier_str_mv ARNALDO, Paulo; et al. Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population. Malays J Med Sci., v.20, n.4, p.13-2, July 2013.
url https://www.arca.fiocruz.br/handle/icict/11581
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Penerbit Universiti Sains
publisher.none.fl_str_mv Penerbit Universiti Sains
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/11581/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/11581/2/adalberto_santos_etal_IOC_2013.pdf
https://www.arca.fiocruz.br/bitstream/icict/11581/3/adalberto_santos_etal_IOC_2013.pdf.txt
bitstream.checksum.fl_str_mv 7d48279ffeed55da8dfe2f8e81f3b81f
96b9bca7a3a2e3f706e18b81b56f82c5
70de9199ed2673cdd023194f240a9c36
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008978492260352

Registros relacionados