Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin

Detalhes bibliográficos
Autor(a) principal: Carvalho, Cristiana Maria Costa Nascimento de
Data de Publicação: 2017
Outros Autores: Souza, Gabriel Xavier, Vilas Boas, Ana Luisa, Fontoura, Maria do Socorro Heitz, Barral, Aldina Maria Prado, Puolakkainen, Mirja, Ruuskanen, Olli
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24829
Resumo: Bahia State Agency for Research Funding (FAPESB) (grant no. APR N . 0127/2006). C. M. N.-C. and A. B. are investigators at the Brazilian Council for Scientific and Technological Development (CNPq).
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spelling Carvalho, Cristiana Maria Costa Nascimento deSouza, Gabriel XavierVilas Boas, Ana LuisaFontoura, Maria do Socorro HeitzBarral, Aldina Maria PradoPuolakkainen, MirjaRuuskanen, Olli2018-02-15T13:18:22Z2018-02-15T13:18:22Z2017CARVALHO, C. M. C. N. et al. Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin. Journal of Antimicrobial Chemotherapy, v. 72, p. 2378–2384, 2017.0305-7453https://www.arca.fiocruz.br/handle/icict/2482910.1093/jac/dkx126Bahia State Agency for Research Funding (FAPESB) (grant no. APR N . 0127/2006). C. M. N.-C. and A. B. are investigators at the Brazilian Council for Scientific and Technological Development (CNPq).Universidade Federal da Bahia. Escola de Medicina. Departamento de Pediatria. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina. Departamento de Pediatria. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina. Departamento de Pediatria. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina. Departamento de Pediatria. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina. Departamento de Patologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Helsinki and University Central Hospital. Virology. Helsinki, FinlandUniversity of Turku. Department of Paediatrics. Turku, FinlandAtypical bacteria are treatable causative agents of community-acquired pneumonia (CAP). However, there is no conclusive evidence that a child with CAP should receive empirical treatment against such agents. Objectives: We assessed the possibility of association between clinical failure and acute infection by these bacteria among children with CAP treated with amoxicillin. Patients and methods: Patients aged 2–59months with non-severe CAP received amoxicillin during prospective follow-up. Acute and convalescent blood samples were collected. Probable acute infection by Mycoplasma pneumoniae (specific IgM antibodies), by Chlamydia pneumoniae or Chlamydia trachomatis (specific IgM antibodies and/or IgG/IgA titre change) was investigated. Outcomes were assessed during follow-up at 2, 5 and 14–28 days. Treatment failure included development of danger signs, persistent fever, tachypnoea or death. ClinicalTrials.gov: NCT01200706. Results: Of 787 children, 86 (10.9%; 95% CI"8.9%–13.3%) had acute M. pneumoniae infection. C. pneumoniae acute infection was found in 79 of 733 (10.8%; 95% CI"8.7%–13.2%) and C. trachomatis was found in 3 of 28 (10.7%; 95%CI"2.8%–26.5%) ,6months old. Among patients with or without treatment failure at 2 days, acute M. pneumoniae infection (11.7% versus 10.7%; P"0.7), acute C. pneumoniae infection (8.5% versus 11.3%; P"0.3) and acute C. trachomatis infection (16.7% versus 9.1%; P"0.5) were found. No significant differences were found with regard to treatment failure at the 5 day evaluation. Overall, amoxicillin was substituted in 3.5% versus 2.7%among patientswith orwithout acute infection by one of these bacteria (P"0.6). Conclusions: The overall substitution rate of amoxicillin was very low. It is not necessary to give an empirical nonb- lactamantibiotic as a first-line option to treat every child between 2 and 59months old with non-severe CAP.engOxfor University PressPneumonia, BacterianaInfecções Adquiridas na ComunidadeAgentes antibacterianosAmoxicilinaHumanosInfantilPneumonia, BacterialCommunity-Acquired InfectionsAnti-Bacterial AgentsAmoxicillinHumansInfantEvolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24829/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarvalho CMN Evolution of acute infection .........pdfCarvalho CMN Evolution of acute infection 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dc.title.pt_BR.fl_str_mv Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin
title Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin
spellingShingle Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin
Carvalho, Cristiana Maria Costa Nascimento de
Pneumonia, Bacteriana
Infecções Adquiridas na Comunidade
Agentes antibacterianos
Amoxicilina
Humanos
Infantil
Pneumonia, Bacterial
Community-Acquired Infections
Anti-Bacterial Agents
Amoxicillin
Humans
Infant
title_short Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin
title_full Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin
title_fullStr Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin
title_full_unstemmed Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin
title_sort Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin
author Carvalho, Cristiana Maria Costa Nascimento de
author_facet Carvalho, Cristiana Maria Costa Nascimento de
Souza, Gabriel Xavier
Vilas Boas, Ana Luisa
Fontoura, Maria do Socorro Heitz
Barral, Aldina Maria Prado
Puolakkainen, Mirja
Ruuskanen, Olli
author_role author
author2 Souza, Gabriel Xavier
Vilas Boas, Ana Luisa
Fontoura, Maria do Socorro Heitz
Barral, Aldina Maria Prado
Puolakkainen, Mirja
Ruuskanen, Olli
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Cristiana Maria Costa Nascimento de
Souza, Gabriel Xavier
Vilas Boas, Ana Luisa
Fontoura, Maria do Socorro Heitz
Barral, Aldina Maria Prado
Puolakkainen, Mirja
Ruuskanen, Olli
dc.subject.other.pt_BR.fl_str_mv Pneumonia, Bacteriana
Infecções Adquiridas na Comunidade
Agentes antibacterianos
Amoxicilina
Humanos
Infantil
topic Pneumonia, Bacteriana
Infecções Adquiridas na Comunidade
Agentes antibacterianos
Amoxicilina
Humanos
Infantil
Pneumonia, Bacterial
Community-Acquired Infections
Anti-Bacterial Agents
Amoxicillin
Humans
Infant
dc.subject.en.pt_BR.fl_str_mv Pneumonia, Bacterial
Community-Acquired Infections
Anti-Bacterial Agents
Amoxicillin
Humans
Infant
description Bahia State Agency for Research Funding (FAPESB) (grant no. APR N . 0127/2006). C. M. N.-C. and A. B. are investigators at the Brazilian Council for Scientific and Technological Development (CNPq).
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-15T13:18:22Z
dc.date.available.fl_str_mv 2018-02-15T13:18:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, C. M. C. N. et al. Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin. Journal of Antimicrobial Chemotherapy, v. 72, p. 2378–2384, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24829
dc.identifier.issn.pt_BR.fl_str_mv 0305-7453
dc.identifier.doi.none.fl_str_mv 10.1093/jac/dkx126
identifier_str_mv CARVALHO, C. M. C. N. et al. Evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin. Journal of Antimicrobial Chemotherapy, v. 72, p. 2378–2384, 2017.
0305-7453
10.1093/jac/dkx126
url https://www.arca.fiocruz.br/handle/icict/24829
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxfor University Press
publisher.none.fl_str_mv Oxfor University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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