New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy
| Main Author: | |
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| Publication Date: | 2012 |
| Other Authors: | , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/18411 |
Summary: | Leiden University Medical Center. Department of Infectious Diseases. Leiden, Netherlands. |
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Geluk, AnnemiekeBobosha, Kidistvan der Ploeg-van Schip, Jolien J.Spencer, John S.Banu, SayeraMartins, Marcia V. S. B.Cho, Sang-NaeFranken, Kees L. M. C.Kim, Hee JinBekele, YonasUddin, Mohammad K. M.Hadi, Sheikh AbdulAseffa, AbrahamPessolani, Maria C. V.Pereira, Geraldo M. B.Dockrell, Hazel M.Ottenhoff, Tom H. M.2017-04-11T17:52:35Z2017-04-11T17:52:35Z2012GELUK, Annemieke; et al. New Biomarkers with Relevance to Leprosy Diagnosis Applicable in Areas Hyperendemic for Leprosy. J Immunol, v.188, n.10, p.4782-4791, Apr. 2012.0022-1767https://www.arca.fiocruz.br/handle/icict/1841110.4049/jimmunol.11034521550-6606engAmerican Association of ImmunologyHanseníaseBiomarcadoresDiagnósticoÁreas HiperendêmicasBiomarkersLeprosyDiagnosisAreas HyperendemicNew biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeiden University Medical Center. Department of Infectious Diseases. Leiden, Netherlands.Leiden University Medical Center. Department of Infectious Diseases. Leiden, Netherlands / Armauer Hansen Research Institute. Addis Ababa, Ethiopia.Leiden University Medical Center. Department of Infectious Diseases. Leiden, Netherlands.Colorado State University. Department of Microbiology, Immunology, and Pathology. Fort Collins, CO, USA.International Center for Diarrhoeal Disease Research Bangladesh. Dhaka 1000, Bangladesh.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Yonsei University College of Medicine. Institute of Immunology and Immunological Diseases. Department of Microbiology. Seoul, LKorea.Leiden University Medical Center. Department of Infectious Diseases. Leiden, Netherlands.Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Rio de Janeiro, RJ, Brasil.Armauer Hansen Research Institute. Addis Ababa, Ethiopia.International Center for Diarrhoeal Disease Research Bangladesh. Dhaka 1000, Bangladesh.International Center for Diarrhoeal Disease Research Bangladesh. Dhaka 1000, Bangladesh.Armauer Hansen Research Institute. Addis Ababa, Ethiopia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Rio de Janeiro, RJ, Brasil.London School of Hygiene and Tropical Medicine. London, United Kingdom.Leiden University Medical Center. Department of Infectious Diseases. Leiden, Netherlands.Leprosy is not eradicable with currently available diagnostics or interventions, as evidenced by its stable incidence. Early diagnosis of Mycobacterium leprae infection should therefore be emphasized in leprosy research. It remains challenging to develop tests based on immunological biomarkers that distinguish individuals controlling bacterial replication from those developing disease. To identify biomarkers for field-applicable diagnostics, we determined cytokines/chemokines induced by M. leprae proteins in blood of leprosy patients and endemic controls (EC) from high leprosy-prevalence areas (Bangladesh, Brazil, Ethiopia) and from South Korea, where leprosy is not endemic anymore. M. leprae-sonicate-induced IFN-γ was similar for all groups, excluding M. leprae/IFN-γ as a diagnostic readout. By contrast, ML2478 and ML0840 induced high IFN-γ concentrations in Bangladeshi EC, which were completely absent for South Korean controls. Importantly, ML2478/IFN-γ could indicate distinct degrees of M. leprae exposure, and thereby the risk of infection and transmission, in different parts of Brazilian and Ethiopian cities. Notwithstanding these discriminatory responses, M. leprae proteins did not distinguish patients from EC in one leprosy-endemic area based on IFN-γ. Analyses of additional cytokines/chemokines showed that M. leprae and ML2478 induced significantly higher concentrations of MCP-1, MIP-1β, and IL-1β in patients compared with EC, whereas IFN-inducible protein-10, like IFN-γ, differed between EC from areas with dissimilar leprosy prevalence. This study identifies M. leprae-unique Ags, particularly ML2478, as biomarker tools to measure M. leprae exposure using IFN-γ or IFN-inducible protein-10, and also shows that MCP-1, MIP-1β, and IL-1β can potentially distinguish pathogenic immune responses from those induced during asymptomatic exposure to M. leprae.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18411/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarcia2_martins_etal_IOC_2012.pdfmarcia2_martins_etal_IOC_2012.pdfapplication/pdf841877https://www.arca.fiocruz.br/bitstream/icict/18411/2/marcia2_martins_etal_IOC_2012.pdf2006d65564172fcce6604dfa042bf5b4MD52TEXTmarcia2_martins_etal_IOC_2012.pdf.txtmarcia2_martins_etal_IOC_2012.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy |
| title |
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy |
| spellingShingle |
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy Geluk, Annemieke Hanseníase Biomarcadores Diagnóstico Áreas Hiperendêmicas Biomarkers Leprosy Diagnosis Areas Hyperendemic |
| title_short |
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy |
| title_full |
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy |
| title_fullStr |
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy |
| title_full_unstemmed |
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy |
| title_sort |
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy |
| author |
Geluk, Annemieke |
| author_facet |
Geluk, Annemieke Bobosha, Kidist van der Ploeg-van Schip, Jolien J. Spencer, John S. Banu, Sayera Martins, Marcia V. S. B. Cho, Sang-Nae Franken, Kees L. M. C. Kim, Hee Jin Bekele, Yonas Uddin, Mohammad K. M. Hadi, Sheikh Abdul Aseffa, Abraham Pessolani, Maria C. V. Pereira, Geraldo M. B. Dockrell, Hazel M. Ottenhoff, Tom H. M. |
| author_role |
author |
| author2 |
Bobosha, Kidist van der Ploeg-van Schip, Jolien J. Spencer, John S. Banu, Sayera Martins, Marcia V. S. B. Cho, Sang-Nae Franken, Kees L. M. C. Kim, Hee Jin Bekele, Yonas Uddin, Mohammad K. M. Hadi, Sheikh Abdul Aseffa, Abraham Pessolani, Maria C. V. Pereira, Geraldo M. B. Dockrell, Hazel M. Ottenhoff, Tom H. M. |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Geluk, Annemieke Bobosha, Kidist van der Ploeg-van Schip, Jolien J. Spencer, John S. Banu, Sayera Martins, Marcia V. S. B. Cho, Sang-Nae Franken, Kees L. M. C. Kim, Hee Jin Bekele, Yonas Uddin, Mohammad K. M. Hadi, Sheikh Abdul Aseffa, Abraham Pessolani, Maria C. V. Pereira, Geraldo M. B. Dockrell, Hazel M. Ottenhoff, Tom H. M. |
| dc.subject.other.pt_BR.fl_str_mv |
Hanseníase Biomarcadores Diagnóstico Áreas Hiperendêmicas |
| topic |
Hanseníase Biomarcadores Diagnóstico Áreas Hiperendêmicas Biomarkers Leprosy Diagnosis Areas Hyperendemic |
| dc.subject.en.pt_BR.fl_str_mv |
Biomarkers Leprosy Diagnosis Areas Hyperendemic |
| description |
Leiden University Medical Center. Department of Infectious Diseases. Leiden, Netherlands. |
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2012 |
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2012 |
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2017-04-11T17:52:35Z |
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2017-04-11T17:52:35Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
GELUK, Annemieke; et al. New Biomarkers with Relevance to Leprosy Diagnosis Applicable in Areas Hyperendemic for Leprosy. J Immunol, v.188, n.10, p.4782-4791, Apr. 2012. |
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https://www.arca.fiocruz.br/handle/icict/18411 |
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0022-1767 |
| dc.identifier.doi.none.fl_str_mv |
10.4049/jimmunol.1103452 |
| dc.identifier.eissn.none.fl_str_mv |
1550-6606 |
| identifier_str_mv |
GELUK, Annemieke; et al. New Biomarkers with Relevance to Leprosy Diagnosis Applicable in Areas Hyperendemic for Leprosy. J Immunol, v.188, n.10, p.4782-4791, Apr. 2012. 0022-1767 10.4049/jimmunol.1103452 1550-6606 |
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American Association of Immunology |
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American Association of Immunology |
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