Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insect

Detalhes bibliográficos
Autor(a) principal: Mesquita, Rafael D.
Data de Publicação: 2021
Outros Autores: Gaviraghi, Alessandro, Gonçalves, Renata L.S., Santos, Marcos A. Vannier, Mignaco, Julio A., Fontes, Carlos Frederico L., Machado, Luciana E. S. F., Oliveira, Marcus F
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48766
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM). Rio de Janeiro, RJ, Brasil.
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spelling Mesquita, Rafael D.Gaviraghi, AlessandroGonçalves, Renata L.S.Santos, Marcos A. VannierMignaco, Julio A.Fontes, Carlos Frederico L.Machado, Luciana E. S. F.Oliveira, Marcus F2021-08-26T17:53:34Z2021-08-26T17:53:34Z2021MESQUITA, Rafael D. et al. Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insects. Cells, v. 10, n. 470, 25 p, Feb. 2021.2073-4409https://www.arca.fiocruz.br/handle/icict/4876610.3390/cells10020470engMDPIMetabolismoBioenergéticaRespiraçãoFosforilação oxidativaRedoxDispersãoMigraçãoHomeostaseKinectisMetabolismBioenergeticsRespirationOxidative phosphorylationRedoxDispersalMigrationHomeostasisKinectisAllosteryPhosphomimeticCytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insectinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM). Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Sabri Ülker Center for Metabolic Research and Department of Molecular Metabolism. Harvard T.H. Chan School of Public Health. Boston, MA 02115, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil..Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil / Universidade de São Paulo. Instituto de Biociências,. Departamento de Genética e Biologia Evolutiva. São Paulo, SP, Brasil.Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM). Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Flight dispersal represents a key aspect of the evolutionary and ecological success of insects, allowing escape from predators, mating, and colonization of new niches. The huge energy demand posed by flight activity is essentially met by oxidative phosphorylation (OXPHOS) in flight muscle mitochondria. In insects, mitochondrial ATP supply and oxidant production are regulated by several factors, including the energy demand exerted by changes in adenylate balance. Indeed, adenylate directly regulates OXPHOS by targeting both chemiosmotic ATP production and the activities of specific mitochondrial enzymes. In several organisms, cytochrome c oxidase (COX) is regulated at transcriptional, post-translational, and allosteric levels, impacting mitochondrial energy metabolism, and redox balance. This review will present the concepts on how COX function contributes to flying insect biology, focusing on the existing examples in the literature where its structure and activity are regulated not only by physiological and environmental factors but also how changes in its activity impacts insect biology. We also performed in silico sequence analyses and determined the structure models of three COX subunits (IV, VIa, and VIc) from different insect species to compare with mammalian orthologs. We observed that the sequences and structure models of COXIV, COXVIa, and COXVIc were quite similar to their mammalian counterparts. Remarkably, specific substitutions to phosphomimetic amino acids at critical phosphorylation sites emerge as hallmarks on insect COX sequences, suggesting a new regulatory mechanism of COX activity. Therefore, by providing a physiological and bioenergetic framework of COX regulation in such metabolically extreme models, we hope to expand the knowledge of this critical enzyme complex and the potential consequences for insect dispersal.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48766/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarcosV_Santos_etal_IOC_2021.pdfMarcosV_Santos_etal_IOC_2021.pdfapplication/pdf2157821https://www.arca.fiocruz.br/bitstream/icict/48766/2/MarcosV_Santos_etal_IOC_2021.pdf05de38cd395f884def290162bcd8e503MD52TEXTMarcosV_Santos_etal_IOC_2021.pdf.txtMarcosV_Santos_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insect
title Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insect
spellingShingle Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insect
Mesquita, Rafael D.
Metabolismo
Bioenergética
Respiração
Fosforilação oxidativa
Redox
Dispersão
Migração
Homeostase
Kinectis
Metabolism
Bioenergetics
Respiration
Oxidative phosphorylation
Redox
Dispersal
Migration
Homeostasis
Kinectis
Allostery
Phosphomimetic
title_short Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insect
title_full Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insect
title_fullStr Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insect
title_full_unstemmed Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insect
title_sort Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insect
author Mesquita, Rafael D.
author_facet Mesquita, Rafael D.
Gaviraghi, Alessandro
Gonçalves, Renata L.S.
Santos, Marcos A. Vannier
Mignaco, Julio A.
Fontes, Carlos Frederico L.
Machado, Luciana E. S. F.
Oliveira, Marcus F
author_role author
author2 Gaviraghi, Alessandro
Gonçalves, Renata L.S.
Santos, Marcos A. Vannier
Mignaco, Julio A.
Fontes, Carlos Frederico L.
Machado, Luciana E. S. F.
Oliveira, Marcus F
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mesquita, Rafael D.
Gaviraghi, Alessandro
Gonçalves, Renata L.S.
Santos, Marcos A. Vannier
Mignaco, Julio A.
Fontes, Carlos Frederico L.
Machado, Luciana E. S. F.
Oliveira, Marcus F
dc.subject.other.pt_BR.fl_str_mv Metabolismo
Bioenergética
Respiração
Fosforilação oxidativa
Redox
Dispersão
Migração
Homeostase
Kinectis
topic Metabolismo
Bioenergética
Respiração
Fosforilação oxidativa
Redox
Dispersão
Migração
Homeostase
Kinectis
Metabolism
Bioenergetics
Respiration
Oxidative phosphorylation
Redox
Dispersal
Migration
Homeostasis
Kinectis
Allostery
Phosphomimetic
dc.subject.en.pt_BR.fl_str_mv Metabolism
Bioenergetics
Respiration
Oxidative phosphorylation
Redox
Dispersal
Migration
Homeostasis
Kinectis
Allostery
Phosphomimetic
description Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM). Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-08-26T17:53:34Z
dc.date.available.fl_str_mv 2021-08-26T17:53:34Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MESQUITA, Rafael D. et al. Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insects. Cells, v. 10, n. 470, 25 p, Feb. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48766
dc.identifier.issn.pt_BR.fl_str_mv 2073-4409
dc.identifier.doi.none.fl_str_mv 10.3390/cells10020470
identifier_str_mv MESQUITA, Rafael D. et al. Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insects. Cells, v. 10, n. 470, 25 p, Feb. 2021.
2073-4409
10.3390/cells10020470
url https://www.arca.fiocruz.br/handle/icict/48766
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/48766/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/48766/2/MarcosV_Santos_etal_IOC_2021.pdf
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