Association between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41272 |
Resumo: | Ministério da Saúde e Organização Pan-Americana da Saúde. |
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Araújo, Thália Velho Barreto deRodrigues, Laura CunhaXimenes, Ricardo Arraes de AlencarMiranda-Filho, Demócrito de BarrosMontarroyos, Ulisses RamosMelo, Ana Paula Lopes deValongueiro, SandraAlbuquerque, Maria de Fátima Pessoa Militão deSouza, Wayner VieiraBraga, CynthiaBrandão Filho, Sinval PintoCordeiro, Marli TenórioVazquez, EnriqueCruz, Danielle di Cavalcanti SouzaHenriques, Cláudio Maierovitch PessanhaBezerra, Luciana Caroline AlbuquerqueCastanha, Priscila Mayrelle da SilvaDhalia, RafaelMarques-Júnior, Ernesto Torres AzevedoMartelli, Celina Maria TurchiMicrocephaly Epidemic Research GroupOrganização Pan-Americana da SaúdeInstituto de Medicina Integral Professor Fernando FigueiraSecretaria Estadual de Saúde de Pernambuco2020-05-18T18:53:29Z2020-05-18T18:53:29Z2016ARAÚJO, Thália Velho Barreto de et al. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet, [New York], v. 16, n. 12, p. 1356-1363, Dec. 2016.1474-4457https://www.arca.fiocruz.br/handle/icict/4127210.1016/S1473-3099(16)30318-8Ministério da Saúde e Organização Pan-Americana da Saúde.Universidade Federal de Pernambuco. Departamento de Medicina Social. Recife, PE, Brasil.London School of Hygiene & Tropical Medicine. Disease Epidemiology. Department of Infectious. London, UK.Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil / Universidade Federal de Pernambuco. Departamento de Saúde Coletiva. Vitória de Santo Antão, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Organização Pan-Americana da Saúde. Brasília, DF, Brasil.Instituto Materno Infantil Fernando Figueira. Recife, PE, Brasil.Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.Governo Estadual de Pernambuco. Secretaria Estadual de Saúde de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.The Global Heath Network. Microcephaly Epidemic Research Group. Oxford, England.Organização Pan-Americana da Saúde. Brasília, DF, Brasil.Instituto de Medicina Integral Professor Fernando Figueira. Caruaru, PE, Brasil.Governo Estadual de Pernambuco. Secretaria Estadual de Saúde de Pernambuco. Recife, PE, Brasil.Background: The microcephaly epidemic, which started in Brazil in 2015, was declared a Public Health Emergency of International Concern by WHO in 2016. We report the preliminary results of a case-control study investigating the association between microcephaly and Zika virus infection during pregnancy. Methods: We did this case-control study in eight public hospitals in Recife, Brazil. Cases were neonates with microcephaly. Two controls (neonates without microcephaly), matched by expected date of delivery and area of residence, were selected for each case. Serum samples of cases and controls and cerebrospinal fluid samples of cases were tested for Zika virus-specific IgM and by quantitative RT-PCR. Laboratory-confirmed Zika virus infection during pregnancy was defined as detection of Zika virus-specific IgM or a positive RT-PCR result in neonates. Maternal serum samples were tested by plaque reduction neutralisation assay for Zika virus and dengue virus. We estimated crude odds ratios (ORs) and 95% CIs using a median unbiased estimator for binary data in an unconditional logistic regression model. We estimated ORs separately for cases with and without radiological evidence of brain abnormalities.Findings: Between Jan 15, 2016, and May 2, 2016, we prospectively recruited 32 cases and 62 controls. 24 (80%) of 30 mothers of cases had Zika virus infection compared with 39 (64%) of 61 mothers of controls (p=0·12). 13 (41%) of 32 cases and none of 62 controls had laboratory-confirmed Zika virus infection; crude overall OR 55·5 (95% CI 8·6–∞); OR 113·3 (95% CI 14·5–∞) for seven cases with brain abnormalities; and OR 24·7 (95% CI 2·9–∞) for four cases without brain abnormalities. Interpretation: Our data suggest that the microcephaly epidemic is a result of congenital Zika virus infection. We await further data from this ongoing study to assess other potential risk factors and to confirm the strength of association in a larger sample size.engElsevierMicrocephalyPregnancyPregnancy Complications, Infectious / epidemiologyZika Virus InfectionZika virus infectionZika virusMicrocephalyInfant, newbornEpidemiologyZika virusInfecção por Zika virusMicrocefaliaRecém-NascidoAssociation between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Association between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control study |
| title |
Association between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control study |
| spellingShingle |
Association between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control study Araújo, Thália Velho Barreto de Microcephaly Pregnancy Pregnancy Complications, Infectious / epidemiology Zika Virus Infection Zika virus infection Zika virus Microcephaly Infant, newborn Epidemiology Zika virus Infecção por Zika virus Microcefalia Recém-Nascido |
| title_short |
Association between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control study |
| title_full |
Association between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control study |
| title_fullStr |
Association between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control study |
| title_full_unstemmed |
Association between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control study |
| title_sort |
Association between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control study |
| author |
Araújo, Thália Velho Barreto de |
| author_facet |
Araújo, Thália Velho Barreto de Rodrigues, Laura Cunha Ximenes, Ricardo Arraes de Alencar Miranda-Filho, Demócrito de Barros Montarroyos, Ulisses Ramos Melo, Ana Paula Lopes de Valongueiro, Sandra Albuquerque, Maria de Fátima Pessoa Militão de Souza, Wayner Vieira Braga, Cynthia Brandão Filho, Sinval Pinto Cordeiro, Marli Tenório Vazquez, Enrique Cruz, Danielle di Cavalcanti Souza Henriques, Cláudio Maierovitch Pessanha Bezerra, Luciana Caroline Albuquerque Castanha, Priscila Mayrelle da Silva Dhalia, Rafael Marques-Júnior, Ernesto Torres Azevedo Martelli, Celina Maria Turchi Microcephaly Epidemic Research Group Organização Pan-Americana da Saúde Instituto de Medicina Integral Professor Fernando Figueira Secretaria Estadual de Saúde de Pernambuco |
| author_role |
author |
| author2 |
Rodrigues, Laura Cunha Ximenes, Ricardo Arraes de Alencar Miranda-Filho, Demócrito de Barros Montarroyos, Ulisses Ramos Melo, Ana Paula Lopes de Valongueiro, Sandra Albuquerque, Maria de Fátima Pessoa Militão de Souza, Wayner Vieira Braga, Cynthia Brandão Filho, Sinval Pinto Cordeiro, Marli Tenório Vazquez, Enrique Cruz, Danielle di Cavalcanti Souza Henriques, Cláudio Maierovitch Pessanha Bezerra, Luciana Caroline Albuquerque Castanha, Priscila Mayrelle da Silva Dhalia, Rafael Marques-Júnior, Ernesto Torres Azevedo Martelli, Celina Maria Turchi Microcephaly Epidemic Research Group Organização Pan-Americana da Saúde Instituto de Medicina Integral Professor Fernando Figueira Secretaria Estadual de Saúde de Pernambuco |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Araújo, Thália Velho Barreto de Rodrigues, Laura Cunha Ximenes, Ricardo Arraes de Alencar Miranda-Filho, Demócrito de Barros Montarroyos, Ulisses Ramos Melo, Ana Paula Lopes de Valongueiro, Sandra Albuquerque, Maria de Fátima Pessoa Militão de Souza, Wayner Vieira Braga, Cynthia Brandão Filho, Sinval Pinto Cordeiro, Marli Tenório Vazquez, Enrique Cruz, Danielle di Cavalcanti Souza Henriques, Cláudio Maierovitch Pessanha Bezerra, Luciana Caroline Albuquerque Castanha, Priscila Mayrelle da Silva Dhalia, Rafael Marques-Júnior, Ernesto Torres Azevedo Martelli, Celina Maria Turchi Microcephaly Epidemic Research Group Organização Pan-Americana da Saúde Instituto de Medicina Integral Professor Fernando Figueira Secretaria Estadual de Saúde de Pernambuco |
| dc.subject.mesh.pt_BR.fl_str_mv |
Microcephaly Pregnancy Pregnancy Complications, Infectious / epidemiology Zika Virus Infection |
| topic |
Microcephaly Pregnancy Pregnancy Complications, Infectious / epidemiology Zika Virus Infection Zika virus infection Zika virus Microcephaly Infant, newborn Epidemiology Zika virus Infecção por Zika virus Microcefalia Recém-Nascido |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus infection Zika virus Microcephaly Infant, newborn Epidemiology |
| dc.subject.decs.pt_BR.fl_str_mv |
Zika virus Infecção por Zika virus Microcefalia Recém-Nascido |
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Ministério da Saúde e Organização Pan-Americana da Saúde. |
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2016 |
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2016 |
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2020-05-18T18:53:29Z |
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2020-05-18T18:53:29Z |
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info:eu-repo/semantics/publishedVersion |
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ARAÚJO, Thália Velho Barreto de et al. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet, [New York], v. 16, n. 12, p. 1356-1363, Dec. 2016. |
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https://www.arca.fiocruz.br/handle/icict/41272 |
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1474-4457 |
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10.1016/S1473-3099(16)30318-8 |
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ARAÚJO, Thália Velho Barreto de et al. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet, [New York], v. 16, n. 12, p. 1356-1363, Dec. 2016. 1474-4457 10.1016/S1473-3099(16)30318-8 |
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