Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill

Detalhes bibliográficos
Autor(a) principal: Menna-Barreto, Rubem F. S.
Data de Publicação: 2019
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35130
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
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spelling Menna-Barreto, Rubem F. S.2019-08-27T17:18:23Z2019-08-27T17:18:23Z2019MENNA-BARRETO, Rubem F. S. Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill. Cell Death & Disease, v. 10, n. 93, p. 1-11, 2019.2041-4889https://www.arca.fiocruz.br/handle/icict/3513010.1038/s41419-019-1370-2engSpringer NatureMorte celularPatogênicos tripanosomatídeosDoença de ChagasCel deathPathogenic trypanosomatidsChagas diseaseCell death pathways in pathogenic trypanosomatids: lessons of (over)killinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Especially in tropical and developing countries, the clinically relevant protozoa Trypanosoma cruzi (Chagas disease), Trypanosoma brucei (sleeping sickness) and Leishmania species (leishmaniasis) stand out and infect millions of people worldwide leading to critical social-economic implications. Low-income populations are mainly affected by these three illnesses that are neglected by the pharmaceutical industry. Current anti-trypanosomatid drugs present variable efficacy with remarkable side effects that almost lead to treatment discontinuation, justifying a continuous search for alternative compounds that interfere with essential and specific parasite pathways. In this scenario, the triggering of trypanosomatid cell death machinery emerges as a promising approach, although the exact mechanisms involved in unicellular eukaryotes are still unclear as well as the controversial biological importance of programmed cell death (PCD). In this review, the mechanisms of autophagy, apoptosis-like cell death and necrosis found in pathogenic trypanosomatids are discussed, as well as their roles in successful infection. Based on the published genomic and proteomic maps, the panel of trypanosomatid cell death molecules was constructed under different experimental conditions. The lack of PCD molecular regulators and executioners in these parasites up to now has led to cell death being classified as an unregulated process or incidental necrosis, despite all morphological evidence published. In this context, the participation of metacaspases in PCD was also not described, and these proteases play a crucial role in proliferation and differentiation processes. On the other hand, autophagic phenotype has been described in trypanosomatids under a great variety of stress conditions (drugs, starvation, among others) suggesting that this process is involved in the turnover of damaged structures in the protozoa and is not a cell death pathway. Death mechanisms of pathogenic trypanosomatids may be involved in pathogenesis, and the identification of parasitespecific regulators could represent a rational and attractive alternative target for drug development for these neglected diseases.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35130/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRubemFS_MennaBarreto_IOC_2019_pdf.pdfRubemFS_MennaBarreto_IOC_2019_pdf.pdfapplication/pdf751628https://www.arca.fiocruz.br/bitstream/icict/35130/2/RubemFS_MennaBarreto_IOC_2019_pdf.pdfff448bb3bf5e5b0d01ce123cadb89690MD52TEXTRubemFS_MennaBarreto_IOC_2019_pdf.pdf.txtRubemFS_MennaBarreto_IOC_2019_pdf.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill
title Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill
spellingShingle Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill
Menna-Barreto, Rubem F. S.
Morte celular
Patogênicos tripanosomatídeos
Doença de Chagas
Cel death
Pathogenic trypanosomatids
Chagas disease
title_short Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill
title_full Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill
title_fullStr Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill
title_full_unstemmed Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill
title_sort Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill
author Menna-Barreto, Rubem F. S.
author_facet Menna-Barreto, Rubem F. S.
author_role author
dc.contributor.author.fl_str_mv Menna-Barreto, Rubem F. S.
dc.subject.other.pt_BR.fl_str_mv Morte celular
Patogênicos tripanosomatídeos
Doença de Chagas
topic Morte celular
Patogênicos tripanosomatídeos
Doença de Chagas
Cel death
Pathogenic trypanosomatids
Chagas disease
dc.subject.en.pt_BR.fl_str_mv Cel death
Pathogenic trypanosomatids
Chagas disease
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-08-27T17:18:23Z
dc.date.available.fl_str_mv 2019-08-27T17:18:23Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENNA-BARRETO, Rubem F. S. Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill. Cell Death & Disease, v. 10, n. 93, p. 1-11, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35130
dc.identifier.issn.pt_BR.fl_str_mv 2041-4889
dc.identifier.doi.pt_BR.fl_str_mv 10.1038/s41419-019-1370-2
identifier_str_mv MENNA-BARRETO, Rubem F. S. Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill. Cell Death & Disease, v. 10, n. 93, p. 1-11, 2019.
2041-4889
10.1038/s41419-019-1370-2
url https://www.arca.fiocruz.br/handle/icict/35130
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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