Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study

Detalhes bibliográficos
Autor(a) principal: Oliveira, Claudia Di Lorenzo
Data de Publicação: 2020
Outros Autores: Nunes, Maria Carmo P, Colosimo, Enrico Antonio, Lima, Emilly Malveira de, Cardoso, Clareci S, Ferreira, Ariela Mota, Oliveira, Lea Campos de, Moreira, Carlos Henrique Valente, Bierrenbach, Ana Luiza, Haikal, Desireé Sant Ana, Peixoto, Sérgio William Viana, Costa, Maria Fernanda Furtado de Lima, Sabino, Ester Cerdeira, Ribeiro, Antonio Luiz P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1161/JAHA.119.014176
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58448
Resumo: Federal University of São João del-Rei. Divinópolis, MG, Brazil.
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spelling Oliveira, Claudia Di LorenzoNunes, Maria Carmo PColosimo, Enrico AntonioLima, Emilly Malveira deCardoso, Clareci SFerreira, Ariela MotaOliveira, Lea Campos deMoreira, Carlos Henrique ValenteBierrenbach, Ana LuizaHaikal, Desireé Sant AnaPeixoto, Sérgio William VianaCosta, Maria Fernanda Furtado de LimaSabino, Ester CerdeiraRibeiro, Antonio Luiz P2023-05-16T18:54:38Z2023-05-16T18:54:38Z2020OLIVEIRA, Claudia Di Lorenzo et al. Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study. J Am Heart Assoc., v. 9, n. 6, e014176, 2020. doi: 10.1161/JAHA.119.014176.2047-9980https://www.arca.fiocruz.br/handle/icict/5844810.1161/JAHA.119.014176engWiley-BlackwellRisk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of São João del-Rei. Divinópolis, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciência Exatas. Department of Statistics. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciência Exatas. Department of Statistics. Belo Horizonte, MG, Brazil.Federal University of São João del-Rei. Divinópolis, MG, Brazil.Health Science Program Universidade Estadual de Montes Claros Montes Claros Brazil.Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas. Laboratório de Investigação Médica. São Paulo, SP, Brazil.Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas. Laboratório de Investigação Médica. São Paulo, SP, Brazil.Hospital Sírio-Libanês. Research and Education Institute. São Paulo, SP, Brazil.Health Science Program Universidade Estadual de Montes Claros Montes Claros Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical e Departamento de Moléstias Infecciosas e Parasitarias. São Paulo, SP, Brazil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brazil.Background Risk stratification of Chagas disease patients in the limited-resource setting would be helpful in crafting management strategies. We developed a score to predict 2-year mortality in patients with Chagas cardiomyopathy from remote endemic areas. Methods and Results This study enrolled 1551 patients with Chagas cardiomyopathy from Minas Gerais State, Brazil, from the SaMi-Trop cohort (The SÃO Paulo-Minas Gerais Tropical Medicine Research Center). Clinical evaluation, ECG, and NT-proBNP (N-terminal pro-B-type natriuretic peptide) were performed. A Cox proportional hazards model was used to develop a prediction model based on the key predictors. The end point was all-cause mortality. The patients were classified into 3 risk categories at baseline (low, <2%; intermediate, >= 2% to 10%; high, >= 10%). External validation was performed by applying the score to an independent population with Chagas disease. After 2 years of follow-up, 110 patients died, with an overall mortality rate of 3.505 deaths per 100 person-years. Based on the nomogram, the independent predictors of mortality were assigned points: age (10 points per decade), New York Heart Association functional class higher than I (15 points), heart rate >= 80 beats/min (20 points), QRS duration >= 150 ms (15 points), and abnormal NT-proBNP adjusted by age (55 points). The observed mortality rates in the low-, intermediate-, and high-risk groups were 0%, 3.6%, and 32.7%, respectively, in the derivation cohort and 3.2%, 8.7%, and 19.1%, respectively, in the validation cohort. The discrimination of the score was good in the development cohort (C statistic: 0.82), and validation cohort (C statistic: 0.71). Conclusions In a large population of patients with Chagas cardiomyopathy, a combination of risk factors accurately predicted early mortality. This helpful simple score could be used in remote areas with limited technological resources.Chagas cardiomyopathyChagas diseasemortalityisk predictionrisk scoreinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALRisk Score for Predicting 2-Year Mortality in Patients.pdfRisk Score for Predicting 2-Year Mortality in Patients.pdfapplication/pdf1745523https://www.arca.fiocruz.br/bitstream/icict/58448/2/Risk%20Score%20for%20Predicting%202-Year%20Mortality%20in%20Patients.pdfebe299a5b38e1d2d068c6eb82463d6b9MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58448/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/584482023-05-16 15:54:38.954oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-16T18:54:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study
title Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study
spellingShingle Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study
Oliveira, Claudia Di Lorenzo
Chagas cardiomyopathy
Chagas disease
mortality
isk prediction
risk score
title_short Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study
title_full Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study
title_fullStr Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study
title_full_unstemmed Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study
title_sort Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study
author Oliveira, Claudia Di Lorenzo
author_facet Oliveira, Claudia Di Lorenzo
Nunes, Maria Carmo P
Colosimo, Enrico Antonio
Lima, Emilly Malveira de
Cardoso, Clareci S
Ferreira, Ariela Mota
Oliveira, Lea Campos de
Moreira, Carlos Henrique Valente
Bierrenbach, Ana Luiza
Haikal, Desireé Sant Ana
Peixoto, Sérgio William Viana
Costa, Maria Fernanda Furtado de Lima
Sabino, Ester Cerdeira
Ribeiro, Antonio Luiz P
author_role author
author2 Nunes, Maria Carmo P
Colosimo, Enrico Antonio
Lima, Emilly Malveira de
Cardoso, Clareci S
Ferreira, Ariela Mota
Oliveira, Lea Campos de
Moreira, Carlos Henrique Valente
Bierrenbach, Ana Luiza
Haikal, Desireé Sant Ana
Peixoto, Sérgio William Viana
Costa, Maria Fernanda Furtado de Lima
Sabino, Ester Cerdeira
Ribeiro, Antonio Luiz P
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Claudia Di Lorenzo
Nunes, Maria Carmo P
Colosimo, Enrico Antonio
Lima, Emilly Malveira de
Cardoso, Clareci S
Ferreira, Ariela Mota
Oliveira, Lea Campos de
Moreira, Carlos Henrique Valente
Bierrenbach, Ana Luiza
Haikal, Desireé Sant Ana
Peixoto, Sérgio William Viana
Costa, Maria Fernanda Furtado de Lima
Sabino, Ester Cerdeira
Ribeiro, Antonio Luiz P
dc.subject.en.en_US.fl_str_mv Chagas cardiomyopathy
Chagas disease
mortality
isk prediction
risk score
topic Chagas cardiomyopathy
Chagas disease
mortality
isk prediction
risk score
description Federal University of São João del-Rei. Divinópolis, MG, Brazil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2023-05-16T18:54:38Z
dc.date.available.fl_str_mv 2023-05-16T18:54:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Claudia Di Lorenzo et al. Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study. J Am Heart Assoc., v. 9, n. 6, e014176, 2020. doi: 10.1161/JAHA.119.014176.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58448
dc.identifier.issn.en_US.fl_str_mv 2047-9980
dc.identifier.doi.none.fl_str_mv 10.1161/JAHA.119.014176
identifier_str_mv OLIVEIRA, Claudia Di Lorenzo et al. Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study. J Am Heart Assoc., v. 9, n. 6, e014176, 2020. doi: 10.1161/JAHA.119.014176.
2047-9980
10.1161/JAHA.119.014176
url https://www.arca.fiocruz.br/handle/icict/58448
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58448/2/Risk%20Score%20for%20Predicting%202-Year%20Mortality%20in%20Patients.pdf
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