Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells

Detalhes bibliográficos
Autor(a) principal: Almeida, Gregório Guilherme
Data de Publicação: 2022
Outros Autores: Rimkute, Inga, Vale, Isabela Natália Pascoal Campos do, Liechti, Thomas, Henriques, Priscilla Miranda, Roffe, Ester, Araújo, Fernanda Fortes de, Rocha, Manoel Otávio da Costa, Carvalho, Andrea Teixeira de, Roederer, Mario, Antonelli, Lis Ribeiro do Valle
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56918
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil
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spelling Almeida, Gregório GuilhermeRimkute, IngaVale, Isabela Natália Pascoal Campos doLiechti, ThomasHenriques, Priscilla MirandaRoffe, EsterAraújo, Fernanda Fortes deRocha, Manoel Otávio da CostaCarvalho, Andrea Teixeira deRoederer, MarioAntonelli, Lis Ribeiro do Valle2023-02-07T14:14:06Z2023-02-07T14:14:06Z2022ALMEIDA Gregório Guilherme, et al. Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells. J Transl Med., v. 20, n. 1, 551, 2022. doi.org/10.1186/s12967-022-03761-51479-5876https://www.arca.fiocruz.br/handle/icict/56918engBioMed CentralChagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, BrazilVaccine Research Center. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USAFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, BrazilVaccine Research Center. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USAFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, BrazilLaboratory of Molecular Immunology. Molecular Signaling Section. National Institutes of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USAFundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, BrasilDepartamento de Clínica Médica, Curso de Pós-Graduação em Infectologia e Medicina Tropical, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, BrasilVaccine Research Center. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USAFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, BrazilChagas disease is a neglected tropical disease in Latin America and an imported emerging disease worldwide. Chronic Chagas disease cardiomyopathy (CCC) is the most prominent clinical form and can lead to heart failure, thromboembolism, and sudden death. While previous reports have supported a role for CD4+ T lymphocytes in the pathogenesis of CCC a comprehensive analysis of these cells during different clinical forms is lacking. Here, we used high-dimensional flow cytometry to assess the diversity of circulating CD4+ T cells in patients with distinct clinical forms. We found increased frequencies of CD4+CD69+ T cells in patients compared to controls. CD39+ regulatory T cells, represented by mesocluster 6 were reduced in mild CCC patients compared to controls. Cytotoxic CD4+ T cells co-expressing granzyme B and perforin were expanded in patients with Chagas disease and were higher in patients with mild CCC compared to controls. Furthermore, patients with mild CCC displayed higher frequencies of multifunctional effector memory CD4+ T cells. Our results demonstrate an expansion in activated CD4+ T cells and a decrease in a functional subset of regulatory T cells associated with the onset of Chagas cardiomyopathy, suggesting their role in the establishment of cardiac lesions and as potential biomarkers for disease aggravation.Chagas diseaseTrypanosoma cruziCardiomyopathyCD4+ T cellsMultifunctionalCytotoxicRegulatoryBiomarkersinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56918/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALChagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells.pdfChagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells.pdfapplication/pdf9549227https://www.arca.fiocruz.br/bitstream/icict/56918/2/Chagasic%20cardiomyopathy%20is%20marked%20by%20a%20unique%20signature%20of%20activated%20CD4%2b%20T%20cells.pdf54b834fbede5d1960d2b1b04e929a7dfMD52icict/569182023-02-07 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dc.title.en_US.fl_str_mv Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells
title Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells
spellingShingle Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells
Almeida, Gregório Guilherme
Chagas disease
Trypanosoma cruzi
Cardiomyopathy
CD4+ T cells
Multifunctional
Cytotoxic
Regulatory
Biomarkers
title_short Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells
title_full Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells
title_fullStr Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells
title_full_unstemmed Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells
title_sort Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells
author Almeida, Gregório Guilherme
author_facet Almeida, Gregório Guilherme
Rimkute, Inga
Vale, Isabela Natália Pascoal Campos do
Liechti, Thomas
Henriques, Priscilla Miranda
Roffe, Ester
Araújo, Fernanda Fortes de
Rocha, Manoel Otávio da Costa
Carvalho, Andrea Teixeira de
Roederer, Mario
Antonelli, Lis Ribeiro do Valle
author_role author
author2 Rimkute, Inga
Vale, Isabela Natália Pascoal Campos do
Liechti, Thomas
Henriques, Priscilla Miranda
Roffe, Ester
Araújo, Fernanda Fortes de
Rocha, Manoel Otávio da Costa
Carvalho, Andrea Teixeira de
Roederer, Mario
Antonelli, Lis Ribeiro do Valle
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Gregório Guilherme
Rimkute, Inga
Vale, Isabela Natália Pascoal Campos do
Liechti, Thomas
Henriques, Priscilla Miranda
Roffe, Ester
Araújo, Fernanda Fortes de
Rocha, Manoel Otávio da Costa
Carvalho, Andrea Teixeira de
Roederer, Mario
Antonelli, Lis Ribeiro do Valle
dc.subject.en.en_US.fl_str_mv Chagas disease
Trypanosoma cruzi
Cardiomyopathy
CD4+ T cells
Multifunctional
Cytotoxic
Regulatory
Biomarkers
topic Chagas disease
Trypanosoma cruzi
Cardiomyopathy
CD4+ T cells
Multifunctional
Cytotoxic
Regulatory
Biomarkers
description Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-02-07T14:14:06Z
dc.date.available.fl_str_mv 2023-02-07T14:14:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA Gregório Guilherme, et al. Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells. J Transl Med., v. 20, n. 1, 551, 2022. doi.org/10.1186/s12967-022-03761-5
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56918
dc.identifier.issn.en_US.fl_str_mv 1479-5876
identifier_str_mv ALMEIDA Gregório Guilherme, et al. Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells. J Transl Med., v. 20, n. 1, 551, 2022. doi.org/10.1186/s12967-022-03761-5
1479-5876
url https://www.arca.fiocruz.br/handle/icict/56918
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56918/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56918/2/Chagasic%20cardiomyopathy%20is%20marked%20by%20a%20unique%20signature%20of%20activated%20CD4%2b%20T%20cells.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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