Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis

Detalhes bibliográficos
Autor(a) principal: Silva, Gabriela Vivili Domingues
Data de Publicação: 2022
Outros Autores: Dolens, Eder da Silva, Paranaíba, Lívia Máris Ribeiro, Ayroza, Ana Lúcia Carrinho, Rocha, Clarissa Araujo Gurgel, Almangush, Alhadi, Salo, Tuula, Brennan, Peter A., Coletta, Ricardo D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56162
Resumo: Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).
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spelling Silva, Gabriela Vivili DominguesDolens, Eder da SilvaParanaíba, Lívia Máris RibeiroAyroza, Ana Lúcia CarrinhoRocha, Clarissa Araujo GurgelAlmangush, AlhadiSalo, TuulaBrennan, Peter A.Coletta, Ricardo D.2022-12-22T14:51:01Z2022-12-22T14:51:01Z2022SILVA, Gabriela Vivili Domingues et al. Exploring the combination of tumor-stroma ratio,tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis. Journal of Oral Pathology and Medicine, p. 1-8, 2022.1600-0714https://www.arca.fiocruz.br/handle/icict/5616210.1111/jop.13359Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).Universidade Estadual de Campinas. Escola de Odontologia Departamento de Diagnóstico Bucal. Piracicaba, SP, Brasil.Universidade Estadual de Campinas. Escola de Odontologia. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil / Universidade de Western Paulista. Escola de Odontologia. Presidente Prudente, SP, Brasil.Federal Universidade de Alfenas. Instituto de Ciências Biomédicas. Departamento de Patologia e Parasitologia. Alfenas, MG, Brasil.Universidade Estadual Oeste do Paraná. Faculdade de Odontologia. Centro de Ciências Biológicas e do Saúde. Cascavel, PR, Brasil.Oswaldo Fundação Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Molecular Biologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Odontologia. Departamento de Propedêutica. Salvador, BA, Brasil.Department of Pathology. University of Turku. Turku, Finland / Department of Oral and Maxillofacial Diseases. University of Helsinki. Helsinki, Finland.Department of Oral and Maxillofacial Diseases. University of Helsinki. Helsinki, Finland / Cancer and Translational Medicine Research Unit. Medical Research Center Oulu. University of Oulu and Oulu University Hospital. Oulu, Finland.Department of Oral and Maxillofacial Surgery. Queen Alexandra Hospital. Portsmouth, UK.Universidade Estadual de Campinas. Escola de Odontologia Departamento de Diagnóstico Bucal. Piracicaba, SP, Brasil / Universidade Estadual de Campinas. Escola de Odontologia. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil.Background: While the relevance of the World Health Organization histopathological grading system as a prognostic tool for oral squamous cell carcinoma has received many critics, other histopathological features such as tumor-troma ratio, tumorinfiltrating lymphocytes, and tumor budding are displaying promising results. Here, we evaluated the prognostic impact of the incorporation of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding into World Health Organization histopathological grading for patients with oral squamous cell carcinoma. Methods: A total of 95 patients with early-stage oral squamous cell carcinoma were enrolled in the study, and World Health Organization tumor grading, tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding were evaluated in surgical slides stained with hematoxylin and eosin. Survival analyses for cancer-specific survival and disease-free survival were performed using Cox regression models, and receiver operating characteristic curves were applied for assessment of the performance of the combinations. Results: Tumor-stroma ratio (stroma-rich) was significantly and independently associated with both shortened cancer-specific survival and poor disease-free survival, individually and in combination with World Health Organization histopathological grading. The combination of tumor-stroma ratio with World Health Organization grading did not improve the discriminatory ability compared to tumor-stroma ratio alone. Although low tumor-infiltrating lymphocytes were associated with shortened cancer-specific survival, the association did not withstand multivariate analysis. However, in combination with World Health Organization grading, low tumor-infiltrating lymphocytes were independently associated with poor cancer-specific survival. The combination of tumor-infiltrating lymphocytes and World Health Organization histopathological grading displayed a better discrimination of poor cancer-specific survival than tumor-infiltrating lymphocytes alone, but not at a significant level. Conclusion: Our findings support tumor-stroma ratio as a potential prognostic marker for patients with oral squamous cell carcinoma, and the incorporation of tumor-infiltrating lymphocytes into the World Health Organization grading system improves the prognostic ability of the tumor grading alone.engWileyCaracterísticas histopatológicasCâncer bucalBrotamento tumoralRelação tumor-estromaClassificação da OMSSistemaHistopathological featuresOral cancerTumor buddingTumor-stroma ratioWHO gradingSystemNeoplasias BucaisExploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSilva, Gabriela V. D. - Exploring the combination of tumor‐stroma.pdfSilva, Gabriela V. D. - Exploring the combination of tumor‐stroma.pdfapplication/pdf980240https://www.arca.fiocruz.br/bitstream/icict/56162/2/Silva%2c%20Gabriela%20V.%20D.%20-%20Exploring%20the%20combination%20of%20tumor%e2%80%90stroma.pdf1f5017da5c76200a24cfda00f91f83afMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56162/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/561622023-03-15 14:32:49.496oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis
title Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis
spellingShingle Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis
Silva, Gabriela Vivili Domingues
Características histopatológicas
Câncer bucal
Brotamento tumoral
Relação tumor-estroma
Classificação da OMS
Sistema
Histopathological features
Oral cancer
Tumor budding
Tumor-stroma ratio
WHO grading
System
Neoplasias Bucais
title_short Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis
title_full Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis
title_fullStr Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis
title_full_unstemmed Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis
title_sort Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis
author Silva, Gabriela Vivili Domingues
author_facet Silva, Gabriela Vivili Domingues
Dolens, Eder da Silva
Paranaíba, Lívia Máris Ribeiro
Ayroza, Ana Lúcia Carrinho
Rocha, Clarissa Araujo Gurgel
Almangush, Alhadi
Salo, Tuula
Brennan, Peter A.
Coletta, Ricardo D.
author_role author
author2 Dolens, Eder da Silva
Paranaíba, Lívia Máris Ribeiro
Ayroza, Ana Lúcia Carrinho
Rocha, Clarissa Araujo Gurgel
Almangush, Alhadi
Salo, Tuula
Brennan, Peter A.
Coletta, Ricardo D.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Gabriela Vivili Domingues
Dolens, Eder da Silva
Paranaíba, Lívia Máris Ribeiro
Ayroza, Ana Lúcia Carrinho
Rocha, Clarissa Araujo Gurgel
Almangush, Alhadi
Salo, Tuula
Brennan, Peter A.
Coletta, Ricardo D.
dc.subject.other.en_US.fl_str_mv Características histopatológicas
Câncer bucal
Brotamento tumoral
Relação tumor-estroma
Classificação da OMS
Sistema
topic Características histopatológicas
Câncer bucal
Brotamento tumoral
Relação tumor-estroma
Classificação da OMS
Sistema
Histopathological features
Oral cancer
Tumor budding
Tumor-stroma ratio
WHO grading
System
Neoplasias Bucais
dc.subject.en.en_US.fl_str_mv Histopathological features
Oral cancer
Tumor budding
Tumor-stroma ratio
WHO grading
System
dc.subject.decs.en_US.fl_str_mv Neoplasias Bucais
description Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-12-22T14:51:01Z
dc.date.available.fl_str_mv 2022-12-22T14:51:01Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Gabriela Vivili Domingues et al. Exploring the combination of tumor-stroma ratio,tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis. Journal of Oral Pathology and Medicine, p. 1-8, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56162
dc.identifier.issn.en_US.fl_str_mv 1600-0714
dc.identifier.doi.none.fl_str_mv 10.1111/jop.13359
identifier_str_mv SILVA, Gabriela Vivili Domingues et al. Exploring the combination of tumor-stroma ratio,tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis. Journal of Oral Pathology and Medicine, p. 1-8, 2022.
1600-0714
10.1111/jop.13359
url https://www.arca.fiocruz.br/handle/icict/56162
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56162/2/Silva%2c%20Gabriela%20V.%20D.%20-%20Exploring%20the%20combination%20of%20tumor%e2%80%90stroma.pdf
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