MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46988 |
Resumo: | Universidade Federal do Paraná. Departamento de Genética. Laboratório de Genética Molecular Humana. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil. |
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Bumiller-Bini, ValériaOliveira-Toré, Camila de FreitasCarvalho, Tamyres MingoranceKretzschmar, Gabriela CanalliGonçalves, Letícia BoslooperAlencar, Nina de MouraGasparetto Filho, Miguel AngeloBeltrame, Marcia HolsbachBoldt, Angelica Beate Winter2021-04-30T18:48:51Z2021-04-30T18:48:51Z2020BUMILLER-BINI, Valéria et al. MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19. Genetics and Molecular Biology, v.44, n. 1 (suppl.1), p. 1–21, 2021.1678-4685https://www.arca.fiocruz.br/handle/icict/4698810.1590/1678-4685-gmb-2020-0199porSociedade Brasileira de GenéticaCOVID-19MASPCoronavirus InfectionsComplement System ProteinsComplement Pathway, Mannose-Binding LectinMannose-Binding Protein-Associated Serine ProteasesBlood CoagulationInfecciones por CoronavirusProteínas del Sistema ComplementoLectina de Unión a Manosa de la Vía del ComplementoSerina Proteasas Asociadas a la Proteína de Unión a la ManosaCoagulación SanguíneaInfections à coronavirusProtéines du système du complémentVoie des lectinesMannose-Binding Protein-Associated Serine ProteasesCoagulation sanguineInfecções por CoronavirusProteínas do Sistema ComplementoLectina de Ligação a Manose da Via do ComplementoSerina Proteases Associadas a Proteína de Ligação a ManoseCoagulação SanguíneaMASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Departamento de Genética. Laboratório de Genética Molecular Humana. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Programa de Pós-Graduação em Medicina Interna e Ciências da Saúde. Laboratório de Imunopatologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Laboratório de Citogenética Humana e Oncogenética. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Laboratório de Genética Molecular Humana. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Laboratório de Genética Molecular Humana. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Laboratório de Genética Molecular Humana. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Laboratório de Genética Molecular Humana. Curitiba, PR, Brasil.Components of the complement system and atypical parameters of coagulation were reported in COVID-19 patients, as well as the exacerbation of the inflammation and coagulation activity. Mannose binding lectin (MBL)- associated serine proteases (MASPs) play an important role in viral recognition and subsequent activation of the lectin pathway of the complement system and blood coagulation, connecting both processes. Genetic variants of MASP1 and MASP2 genes are further associated with different levels and functional efficiency of their encoded proteins, modulating susceptibility and severity to diseases. Our review highlights the possible role of MASPs in SARS-COV-2 binding and activation of the lectin pathway and blood coagulation cascades, as well as their associations with comorbidities of COVID-19. MASP-1 and/or MASP-2 present an increased expression in patients with COVID-19 risk factors: diabetes, arterial hypertension and cardiovascular disease, chronic kidney disease, chronic obstructive pulmonary disease, and cerebrovascular disease. Based also on the positive results of COVID-19 patients with antiMASP-2 antibody, we propose the use of MASPs as a possible biomarker of the progression of COVID-19 and the investigation of new treatment strategies taking into consideration the dual role of MASPs, including MASP inhibitors as promising therapeutic targets against COVID-19.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/46988/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINAL1415-4757-GMB-44-1-s1-e202001ok.pdf1415-4757-GMB-44-1-s1-e202001ok.pdfapplication/pdf2567416https://www.arca.fiocruz.br/bitstream/icict/46988/2/1415-4757-GMB-44-1-s1-e202001ok.pdf763f6f6b56435cc0479681633f470347MD52TEXT1415-4757-GMB-44-1-s1-e202001ok.pdf.txt1415-4757-GMB-44-1-s1-e202001ok.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 |
| title |
MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 |
| spellingShingle |
MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 Bumiller-Bini, Valéria COVID-19 MASP Coronavirus Infections Complement System Proteins Complement Pathway, Mannose-Binding Lectin Mannose-Binding Protein-Associated Serine Proteases Blood Coagulation Infecciones por Coronavirus Proteínas del Sistema Complemento Lectina de Unión a Manosa de la Vía del Complemento Serina Proteasas Asociadas a la Proteína de Unión a la Manosa Coagulación Sanguínea Infections à coronavirus Protéines du système du complément Voie des lectines Mannose-Binding Protein-Associated Serine Proteases Coagulation sanguine Infecções por Coronavirus Proteínas do Sistema Complemento Lectina de Ligação a Manose da Via do Complemento Serina Proteases Associadas a Proteína de Ligação a Manose Coagulação Sanguínea |
| title_short |
MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 |
| title_full |
MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 |
| title_fullStr |
MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 |
| title_full_unstemmed |
MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 |
| title_sort |
MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 |
| author |
Bumiller-Bini, Valéria |
| author_facet |
Bumiller-Bini, Valéria Oliveira-Toré, Camila de Freitas Carvalho, Tamyres Mingorance Kretzschmar, Gabriela Canalli Gonçalves, Letícia Boslooper Alencar, Nina de Moura Gasparetto Filho, Miguel Angelo Beltrame, Marcia Holsbach Boldt, Angelica Beate Winter |
| author_role |
author |
| author2 |
Oliveira-Toré, Camila de Freitas Carvalho, Tamyres Mingorance Kretzschmar, Gabriela Canalli Gonçalves, Letícia Boslooper Alencar, Nina de Moura Gasparetto Filho, Miguel Angelo Beltrame, Marcia Holsbach Boldt, Angelica Beate Winter |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bumiller-Bini, Valéria Oliveira-Toré, Camila de Freitas Carvalho, Tamyres Mingorance Kretzschmar, Gabriela Canalli Gonçalves, Letícia Boslooper Alencar, Nina de Moura Gasparetto Filho, Miguel Angelo Beltrame, Marcia Holsbach Boldt, Angelica Beate Winter |
| dc.subject.other.pt_BR.fl_str_mv |
COVID-19 MASP |
| topic |
COVID-19 MASP Coronavirus Infections Complement System Proteins Complement Pathway, Mannose-Binding Lectin Mannose-Binding Protein-Associated Serine Proteases Blood Coagulation Infecciones por Coronavirus Proteínas del Sistema Complemento Lectina de Unión a Manosa de la Vía del Complemento Serina Proteasas Asociadas a la Proteína de Unión a la Manosa Coagulación Sanguínea Infections à coronavirus Protéines du système du complément Voie des lectines Mannose-Binding Protein-Associated Serine Proteases Coagulation sanguine Infecções por Coronavirus Proteínas do Sistema Complemento Lectina de Ligação a Manose da Via do Complemento Serina Proteases Associadas a Proteína de Ligação a Manose Coagulação Sanguínea |
| dc.subject.en.pt_BR.fl_str_mv |
Coronavirus Infections Complement System Proteins Complement Pathway, Mannose-Binding Lectin Mannose-Binding Protein-Associated Serine Proteases Blood Coagulation |
| dc.subject.es.pt_BR.fl_str_mv |
Infecciones por Coronavirus Proteínas del Sistema Complemento Lectina de Unión a Manosa de la Vía del Complemento Serina Proteasas Asociadas a la Proteína de Unión a la Manosa Coagulación Sanguínea |
| dc.subject.fr.pt_BR.fl_str_mv |
Infections à coronavirus Protéines du système du complément Voie des lectines Mannose-Binding Protein-Associated Serine Proteases Coagulation sanguine |
| dc.subject.decs.pt_BR.fl_str_mv |
Infecções por Coronavirus Proteínas do Sistema Complemento Lectina de Ligação a Manose da Via do Complemento Serina Proteases Associadas a Proteína de Ligação a Manose Coagulação Sanguínea |
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Universidade Federal do Paraná. Departamento de Genética. Laboratório de Genética Molecular Humana. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil. |
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2020 |
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2020 |
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2021-04-30T18:48:51Z |
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2021-04-30T18:48:51Z |
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BUMILLER-BINI, Valéria et al. MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19. Genetics and Molecular Biology, v.44, n. 1 (suppl.1), p. 1–21, 2021. |
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https://www.arca.fiocruz.br/handle/icict/46988 |
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1678-4685 |
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10.1590/1678-4685-gmb-2020-0199 |
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BUMILLER-BINI, Valéria et al. MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19. Genetics and Molecular Biology, v.44, n. 1 (suppl.1), p. 1–21, 2021. 1678-4685 10.1590/1678-4685-gmb-2020-0199 |
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